Results 211 to 220 of about 23,034 (262)
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Membrane Interactions of Dynorphins,
Biochemistry, 2006The dynorphins are primarily endogenous ligands to the kappa-opioid receptor, but a variety of non-opioid effects have also been observed, including direct effects on membranes. The peptides are rich in Arg residues, a characteristic feature of the cell-penetrating peptides.
Jesper, Lind +2 more
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Dynorphin-independent spinal cannabinoid antinociception
Pain, 2002Spinal antinociception produced by delta 9-tetrahydro-cannabinol (Delta(9)-THC) and other cannabinoid agonists has been suggested to be mediated by the release of dynorphin acting at the kappa opioid receptor. Alternatively, as cannabinoid receptors are distributed appropriately in the pain transmission pathway, cannabinoid agonists might act directly ...
L R, Gardell +4 more
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Generation of dynorphin knockout mice
Molecular Brain Research, 2001The opioid system has important roles in controlling pain, reward and addiction, and is implicated in numerous other processes within and outside the nervous system, such as mood states, immune responses, and prenatal developmental processes. The effects of the opioid system are mediated by at least three ligands, enkephalin, endorphin, and dynorphin ...
N, Sharifi +4 more
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European Journal of Pharmacology, 1989
In both rats and humans there is an analgesia associated with pregnancy. This analgesia is spinally mediated and involves the kappa type of opiate receptor. The current study demonstrates that intrathecal administration of high affinity dynorphin antibodies produces a significant reduction in jump thresholds during pregnancy (day 20).
H W, Sander, R M, Kream, A R, Gintzler
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In both rats and humans there is an analgesia associated with pregnancy. This analgesia is spinally mediated and involves the kappa type of opiate receptor. The current study demonstrates that intrathecal administration of high affinity dynorphin antibodies produces a significant reduction in jump thresholds during pregnancy (day 20).
H W, Sander, R M, Kream, A R, Gintzler
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Dynorphin(1–10)amide: A potent and selective analog of dynorphin(1–13)
Life Sciences, 1982Dynorphin(1-10)amide was more potent than Dynorphin(1-13) in inhibiting the twitch of the mouse vas deferens (IC50 of Dynorphin(1-10)amide = 0.3 nM and IC50 of Dynorphin (1-13) = 4.0 nM). Binding assays indicated that two opioid peptides had similar profiles in that they enhanced dihydromorphine (DHM) binding in picomolar concentrations but displaced ...
S, Woo +5 more
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Sites of analgesic action of dynorphin
Life Sciences, 1983Analgesic effects of dynorphin and dynorphin-(1-13) injected into various regions of the CNS of rats were investigated using the tail pinch method. Dynorphin and dynorphin-(1-13) produced a dose-dependent analgesic effect when injected into the third ventricle (3rd vent.) or the nuclei reticularis gigantocellularis and paragigantocellularis (NRGC-NRPG)
T, Kaneko +7 more
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Cytokine involvement in dynorphin-induced allodynia
Pain, 2000Dynorphin A is an endogenous opioid peptide, which has previously been shown to produce a long-lasting allodynia and hyperalgesia in mice, behavioral states consistent with signs of clinically observed neuropathic pain. This dynorphin-induced allodynia was used as a pharmacological, central model of neuropathic pain.
T M, Laughlin +3 more
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Dynorphin Peptides: Antagonists of Melanocortin Receptors
Pharmaceutical Research, 1997To identify possible targets that mediate the non-opioid effects of dynorphin-A (DynA), effects that include inflammation and aggravation of traumatic nerve injury.We examined dynorphin peptides for functional interaction with the closely related melanocortin (MC) system.DynA-(1-13)NH2 and other related opioid dynorphin peptides antagonize the human ...
J M, Quillan, W, Sadée
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Dysregulation of dynorphins in Alzheimer disease
Neurobiology of Aging, 2007The opioid peptides dynorphins may be involved in pathogenesis of Alzheimer disease (AD) by inducing neurodegeneration or cognitive impairment. To test this hypothesis, the dynorphin system was analyzed in postmortem samples from AD and control subjects, and subjects with Parkinson or cerebro-vascular diseases for comparison.
T, Yakovleva +6 more
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Two “big” dynorphins from porcine pituitary
Life Sciences, 1982Abstract Two dynorphins of 24 and 32 residues, respectively, were isolated from porcine pituitary and sequenced. They both contain the dynorphin heptadecapeptide, now designated dynorphin A, at the amino terminus, followed immediately by the putative processing signal Lys-Arg.
W, Fischli +3 more
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