Results 211 to 220 of about 19,170 (265)
Some of the next articles are maybe not open access.
Nonopiate Effects of Dynorphin and Des-Tyr-Dynorphin
Science, 1982Intracerebroventricular administration of dynorphin produced potent and long-lasting effects on motor function and the electroencephalogram in rats. In addition, local iontophoretic or pressure ejection of dynorphin consistently inhibited hippocampal unit activity.
J M, Walker +4 more
openaire +2 more sources
Biochemical and Biophysical Research Communications, 1983
Rimorphin (dynorphin B) has been demonstrated to exist together with alpha-neo-endorphin and dynorphin(1-17) (dynorphin A) in the human hypothalamus. The content of rimorphin was comparable to that of alpha-neo-endorphin and somewhat higher than that of dynorphin. This result is quite similar to the recent observations in bovine, porcine and rat neural
K, Nakao +6 more
openaire +2 more sources
Rimorphin (dynorphin B) has been demonstrated to exist together with alpha-neo-endorphin and dynorphin(1-17) (dynorphin A) in the human hypothalamus. The content of rimorphin was comparable to that of alpha-neo-endorphin and somewhat higher than that of dynorphin. This result is quite similar to the recent observations in bovine, porcine and rat neural
K, Nakao +6 more
openaire +2 more sources
Journal of Neurochemistry, 1986
AbstractDynorphin B (rimorphin) is formed from leumorphin (dynorphin B‐29) by the action of a thiol protease from rat brain membranes, in a single step. This represents a “single‐arginine cleavage” between threonine‐13 and arginine‐14 of the substrate. We have observed that in addition to dynorphin B, dynorphin B‐14 is formed from dynorphin B‐29. Among
L, Devi, A, Goldstein
openaire +2 more sources
AbstractDynorphin B (rimorphin) is formed from leumorphin (dynorphin B‐29) by the action of a thiol protease from rat brain membranes, in a single step. This represents a “single‐arginine cleavage” between threonine‐13 and arginine‐14 of the substrate. We have observed that in addition to dynorphin B, dynorphin B‐14 is formed from dynorphin B‐29. Among
L, Devi, A, Goldstein
openaire +2 more sources
International Journal of Peptide and Protein Research, 1984
Dynorphin‐(1–13) (Dyn‐(1–13)) and its analogs substituted by single introduction of Ala in positions 1–11 were synthesized by the solid‐phase method and purified by high pressure liquid chromatography. Relative potencies of the synthetic compounds were determined by their ability to inhibit electrically‐evoked contractions of the guinea pig ileum (GPI)
Andree Turcotte +3 more
openaire +1 more source
Dynorphin‐(1–13) (Dyn‐(1–13)) and its analogs substituted by single introduction of Ala in positions 1–11 were synthesized by the solid‐phase method and purified by high pressure liquid chromatography. Relative potencies of the synthetic compounds were determined by their ability to inhibit electrically‐evoked contractions of the guinea pig ileum (GPI)
Andree Turcotte +3 more
openaire +1 more source
Dynorphin, won’t you myelinate my neighbor?
Neuron, 2021Accumulating evidence supports the prevalence of experience-dependent oligodendrocyte precursor cell (OPC) differentiation and myelination in learning and memory. However, the mechanisms remain unknown. In this issue of Neuron, Osso et al., (2021) report that stress causes the secretion of dynorphin by unmyelinated axons, which induces OPC ...
Xiaoyun, Ding, Matthew N, Rasband
openaire +2 more sources
Membrane Interactions of Dynorphins,
Biochemistry, 2006The dynorphins are primarily endogenous ligands to the kappa-opioid receptor, but a variety of non-opioid effects have also been observed, including direct effects on membranes. The peptides are rich in Arg residues, a characteristic feature of the cell-penetrating peptides.
Jesper, Lind +2 more
openaire +2 more sources
Dynorphin-independent spinal cannabinoid antinociception
Pain, 2002Spinal antinociception produced by delta 9-tetrahydro-cannabinol (Delta(9)-THC) and other cannabinoid agonists has been suggested to be mediated by the release of dynorphin acting at the kappa opioid receptor. Alternatively, as cannabinoid receptors are distributed appropriately in the pain transmission pathway, cannabinoid agonists might act directly ...
L R, Gardell +4 more
openaire +2 more sources
Generation of dynorphin knockout mice
Molecular Brain Research, 2001The opioid system has important roles in controlling pain, reward and addiction, and is implicated in numerous other processes within and outside the nervous system, such as mood states, immune responses, and prenatal developmental processes. The effects of the opioid system are mediated by at least three ligands, enkephalin, endorphin, and dynorphin ...
N, Sharifi +4 more
openaire +2 more sources
European Journal of Pharmacology, 1989
In both rats and humans there is an analgesia associated with pregnancy. This analgesia is spinally mediated and involves the kappa type of opiate receptor. The current study demonstrates that intrathecal administration of high affinity dynorphin antibodies produces a significant reduction in jump thresholds during pregnancy (day 20).
H W, Sander, R M, Kream, A R, Gintzler
openaire +2 more sources
In both rats and humans there is an analgesia associated with pregnancy. This analgesia is spinally mediated and involves the kappa type of opiate receptor. The current study demonstrates that intrathecal administration of high affinity dynorphin antibodies produces a significant reduction in jump thresholds during pregnancy (day 20).
H W, Sander, R M, Kream, A R, Gintzler
openaire +2 more sources
Dynorphin(1–10)amide: A potent and selective analog of dynorphin(1–13)
Life Sciences, 1982Dynorphin(1-10)amide was more potent than Dynorphin(1-13) in inhibiting the twitch of the mouse vas deferens (IC50 of Dynorphin(1-10)amide = 0.3 nM and IC50 of Dynorphin (1-13) = 4.0 nM). Binding assays indicated that two opioid peptides had similar profiles in that they enhanced dihydromorphine (DHM) binding in picomolar concentrations but displaced ...
S, Woo +5 more
openaire +2 more sources