Results 141 to 150 of about 8,125 (179)

A specific radioimmunoassay for the novel opioid peptide dynorphin

Life Sciences, 1980
Abstract Dynorphin was recently isolated from porcine pituitary extracts and shown to be the most potent known opioid peptide. Antisera were prepared to synthetic dynorphin-(1–13), the biologically active NH 2 -terminal fragment of the peptide. A high-titer, sensitive antiserum was characterized with fragments from dynorphin-(1–13).
V E, Ghazarossian, C, Chavkin, A, Goldstein   +2 more
openaire   +2 more sources

Analgesic effects of dynorphin-A and morphine in mice

Peptides, 1985
To investigate whether or not dynorphin-A is analgesic, the effect of this peptide was tested in comparison with that of morphine in mice. Dynorphin-A produced a potent analgesic effect in the acetic acid writhing and tail pinch tests, but a weak effect in the tail flick test when given by intracerebroventricular injection. In contrast, morphine caused
T, Nakazawa, M, Ikeda, T, Kaneko, K, Yamatsu   +3 more
openaire   +2 more sources

Dynorphin A inhibits NMDA receptors through a pH-dependent mechanism

Molecular and Cellular Neuroscience, 2003
Dynorphin A (DynA), an endogenous agonist of kappa-opioid receptors, has also been reported to directly interact with the NMDA receptor. DynA inhibition of NMDA receptor function has been suggested to be involved in its neuroprotective action during ischemic and acidic conditions.
Yoshio, Kanemitsu, Masako, Hosoi, Ping Jun, Zhu, Forrest F, Weight, Robert W, Peoples, Joseph S, McLaughlin, Li, Zhang   +6 more
openaire   +2 more sources

Metabolism of dynorphin A(1-13).

Die Pharmazie, 2004
Dynorphin A(1-13), a tridecapeptide of the endogenous opioid peptides, has modest effects in reducing mild opiate withdrawal in humans. Previous studies revealed that dynorphin also potentiates the analgesic effect of morphine in morphine-tolerant rats and mice.
B, Brugos, G, Hochhaus
openaire   +1 more source

Characterization of dynorphin A-induced antinociception at spinal level

European Journal of Pharmacology, 1985
Dynorphin A (DYN A) injected intrathecally in the rat produced a significant elevation of the nociceptive threshold, measured by the tail flick test. The highest dose of DYN A (25 nmol) produced maximal elevation of tail flick latency to radiant heat together with hindlimb paralysis and tail flaccidity lasting several hours, thus confirming several ...
S, Spampinato, S, Candeletti
openaire   +2 more sources

Physical dependence liability of dynorphin A analogs in rodents

European Journal of Pharmacology, 1991
To assess the physical dependence liability of dynorphin A analogs, mice were given repeated injections of various dynorphin A analogs twice daily for 5 days, and rats were given repeated administration of [N-methyl-Tyr1,N-methyl-Arg7,D-Leu8]dynorphin-A-(1-8) ethylamide (E-2078) twice daily for up to 7 weeks.
T, Nakazawa, T, Kaneko, H, Yoshino, S, Tachibana, M, Goto, T, Taki, K, Yamatsu   +6 more
openaire   +2 more sources

Dynorphin A Peptides

CNS Drugs, 2000
Michael Sch??fer, Alexander Brack, Christoph Stein   +2 more
openaire   +1 more source

Dynorphin modulates motivation through a pallido-amygdala cholinergic circuit

SUMMARYThe endogenous opioid peptide dynorphin and its receptor κ-opioid receptor (KOR) have been implicated in divergent behaviors, but the underlying mechanisms remain elusive. Here we show that dynorphin released from nucleus accumbens dynorphinergic neurons exerts powerful modulation over a ventral pallidum (VP) disinhibitory circuit, thereby ...
Qingtao Sun, Mingzhe Liu, Wuqiang Guan, Xiong Xiao, Chunyang Dong, Michael R. Bruchas, Larry S. Zweifel, Yulong Li, Lin Tian, Bo Li   +9 more
openaire   +2 more sources

Dynorphin a affects biliary secretion

Pharmacological Research Communications, 1988
E. Speroni, E. Cavicchini, S. Ferri
openaire   +1 more source

Experience-dependent myelination following stress is mediated by the neuropeptide dynorphin

Neuron, 2021
Jonah R Chan
exaly