Functional Characterization of Spinocerebellar Ataxia Associated Dynorphin A Mutant Peptides [PDF]
Biomedicines, 2021 Mutations in the prodynorphin gene (PDYN) are associated with the development of spinocerebellar ataxia type 23 (SCA23). Pathogenic missense mutations are localized predominantly in the PDYN region coding for the dynorphin A (DynA) neuropeptide and lead ...
Andreas Lieb +6 more
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Label-free, real-time monitoring of membrane binding events at zeptomolar concentrations using frequency-locked optical microresonators [PDF]
Nature CommunicationsG-protein coupled receptors help regulate cellular function and communication, and are targets of small molecule drug discovery efforts. Conventional techniques to probe these interactions require labels and large amounts of receptor to achieve ...
Adley Gin +6 more
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Mechanism of elevated LH/FSH ratio in lean PCOS revisited: a path analysis [PDF]
Scientific ReportsPolycystic ovary syndrome (PCOS) is the most common endocrine disorder affecting 5–20% of reproductive-age women. However, the treatment of PCOS is mainly based on symptoms and not on its pathophysiology.
Gita Pratama +6 more
doaj +2 more sources
Malnutrition alters protein expression of KNDy neuropeptides in the arcuate nucleus of mature ewes [PDF]
Frontiers in PhysiologyThe neuropeptides kisspeptin, neurokinin B, and dynorphin A are imperative for the pulsatile secretion of gonadotropin-releasing hormone and luteinizing hormone to ultimately regulate reproductive cyclicity.
Jennifer F. Thorson, Ligia D. Prezotto
doaj +2 more sources
Structural basis of divergent substrate recognition and inhibition of human neurolysin [PDF]
Scientific ReportsA zinc metallopeptidase neurolysin (Nln) processes diverse bioactive peptides to regulate signaling in the mammalian nervous system. To understand how Nln interacts with various peptides with dissimilar sequences, we determined crystal structures of Nln ...
Ke Shi +7 more
doaj +2 more sources
Kappa opioid receptor and dynorphin signaling in the central amygdala regulates alcohol intake
Molecular Psychiatry, 2020 Dipanwita Pati +2 more
exaly +3 more sources
Most dynorphin neurons in the zona incerta-perifornical area are active in waking relative to non-rapid-eye movement and rapid-eye movement sleep. [PDF]
SleepShiromani PJ, Vidal-Ortiz A.
europepmc +3 more sources
Food and the brain: Neural and endocrine control of feeding, metabolism, and reproduction. [PDF]
J NeuroendocrinolAbstract Feeding and reproductive function are regulated by intricate systems that monitor food availability and energy stores, and on the basis of energy status, promote or put a brake on reproduction. This is particularly evident in the systems that regulate feeding and reproductive state in female mammals.
da Silva Mansano N, Lieu CV, Abizaid A.
europepmc +2 more sources
eLife, 2021 Many signal transduction systems have an apparent redundancy built into them, where multiple physiological agonists activate the same receptors. Whether this is true redundancy, or whether this provides an as-yet unrecognized specificity in downstream ...
Jennifer M Kunselman +4 more
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Kisspeptin, Neurokinin B, and Dynorphin Expression during Pubertal Development in Female Sheep
Biology, 2021 The neural mechanisms underlying increases in gonadotropin-releasing hormone (GnRH) and luteinizing hormone (LH) secretion that drive puberty onset are unknown.
Eliana G. Aerts +6 more
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