Structural basis of divergent substrate recognition and inhibition of human neurolysin [PDF]
Scientific ReportsA zinc metallopeptidase neurolysin (Nln) processes diverse bioactive peptides to regulate signaling in the mammalian nervous system. To understand how Nln interacts with various peptides with dissimilar sequences, we determined crystal structures of Nln ...
Ke Shi +7 more
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Malnutrition alters protein expression of KNDy neuropeptides in the arcuate nucleus of mature ewes [PDF]
Frontiers in PhysiologyThe neuropeptides kisspeptin, neurokinin B, and dynorphin A are imperative for the pulsatile secretion of gonadotropin-releasing hormone and luteinizing hormone to ultimately regulate reproductive cyclicity.
Jennifer F. Thorson, Ligia D. Prezotto
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Mechanism of elevated LH/FSH ratio in lean PCOS revisited: a path analysis [PDF]
Scientific ReportsPolycystic ovary syndrome (PCOS) is the most common endocrine disorder affecting 5–20% of reproductive-age women. However, the treatment of PCOS is mainly based on symptoms and not on its pathophysiology.
Gita Pratama +6 more
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Altered expression of kisspeptin, dynorphin, and related neuropeptides in polycystic ovary syndrome: A cross-sectional study [PDF]
International Journal of Reproductive BioMedicineBackground: Since kisspeptin (KISS1) in the hypothalamus is affected by the inhibitory effect of dynorphin, it raises questions about the controlled balance of these 2 neuropeptides in women with and without polycystic ovary syndrome (PCOS).
Andon Hestiantoro +7 more
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Nature CommunicationsThe hippocampus is pivotal in integrating emotional processing, learning, memory, and reward-related behaviors. The dorsal hippocampus (dHPC) is particularly crucial for episodic, spatial, and associative memory, and has been shown to be necessary for ...
Khairunisa Mohamad Ibrahim +15 more
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Interaction between corticotropin-releasing factor, orexin, and dynorphin in the infralimbic cortex may mediate exacerbated alcohol-seeking behavior [PDF]
Neurobiology of StressA major challenge for the treatment of alcohol use disorder (AUD) is relapse to alcohol use, even after protracted periods of self-imposed abstinence. Stress significantly contributes to the chronic relapsing nature of AUD, given its long-lasting ability
Francisco J. Flores-Ramirez +2 more
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Dynorphin A (1–13) Neurotoxicity in Vitro: Opioid and Non-Opioid Mechanisms in Mouse Spinal Cord Neurons [PDF]
Experimental Neurology, 1999 Kurt F. Hauser +2 more
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Reversion of muscarinic autoreceptor agonist‐induced acetylcholine decrease and learning impairment by dynorphin A (1–13), an endogenous κ‐opioid receptor agonist [PDF]
British Journal of Pharmacology, 1998 Masayuki Hiramatsu +3 more
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eLife, 2021 Many signal transduction systems have an apparent redundancy built into them, where multiple physiological agonists activate the same receptors. Whether this is true redundancy, or whether this provides an as-yet unrecognized specificity in downstream ...
Jennifer M Kunselman +4 more
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Dynorphin, stress, and depression [PDF]
Brain Research, 2010 Stress is most often associated with aversive states. It rapidly induces the release of hormones and neuropeptides including dynorphin, which activates kappa opioid receptors (KORs) in the central and peripheral nervous systems. In animal models, many aversive effects of stress are mimicked or exacerbated by stimulation of KORs in limbic brain regions.
Allison T. Knoll, William A. Carlezon
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