Results 21 to 30 of about 8,125 (179)

Purification and Characterization of a Dynorphin-processing Endopeptidase [PDF]

Journal of Biological Chemistry, 1995
Dynorphin B (Dyn B-13, also known as rimorphin) is generated from Dyn B-29 (leumorphin) by the cleavage at a single Arg residue. An enzymatic activity capable of processing at this monobasic site has been previously reported in neurosecretory vesicles of the bovine pituitary and pituitary-derived cell lines. This enzyme termed "the dynorphin-converting
Berman, Y. L., Juliano, Luiz UNIFESP, Devi, L. A.   +2 more
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CRF1-R activation of the dynorphin/kappa opioid system in the mouse basolateral amygdala mediates anxiety-like behavior.

PLoS ONE, 2009
Stress is a complex human experience and having both rewarding and aversive motivational properties. The adverse effects of stress are well documented, yet many of underlying mechanisms remain unclear and controversial. Here we report that the anxiogenic
Michael R Bruchas, Benjamin B Land, Julia C Lemos, Charles Chavkin   +3 more
doaj   +1 more source

The dynorphin/kappa opioid receptor mediates adverse immunological and behavioral outcomes induced by repetitive blast trauma

Journal of Neuroinflammation, 2022
Background Adverse pathophysiological and behavioral outcomes related to mild traumatic brain injury (mTBI), posttraumatic stress disorder (PTSD), and chronic pain are common following blast exposure and contribute to decreased quality of life, but ...
Suhjung Janet Lee, Aric F. Logsdon, Mayumi Yagi, Britahny M. Baskin, Elaine. R. Peskind, Murray M. Raskind, David G. Cook, Abigail. G. Schindler   +7 more
doaj   +1 more source

Ester hydrolysis differentially reduces aconitine-induced anti-hypersensitivity and acute neurotoxicity: Involvement of spinal microglial dynorphin expression and implications for Aconitum processing

Frontiers in Pharmacology, 2016
Aconitines, including bulleyaconitine A, probably the most bioactive and abundant alkaloids in Aconitum plant, are a group of diester C19-diterpenoid alkaloids with one acetylester group attached to C8 of the diterpenoid skeleton and one benzoylester ...
Teng-Fei Li, Yong-Xiang Wang, Nian Gong
doaj   +1 more source

Endogenous Opioid Levels Do Not Correlate With Itch Intensity and Therapeutic Interventions in Hepatic Pruritus

Frontiers in Medicine, 2021
Background: Chronic pruritus affects up to 70% of patients with immune-mediated hepatobiliary disorders. Antagonists of the μ-opioid receptor (MOR) and agonists of the κ-opioid receptor (KOR) are used to treat hepatic itch, albeit with limited success ...
Miriam M. Düll, Katharina Wolf, Marcel Vetter, Peter Dietrich, Peter Dietrich, Markus F. Neurath, Markus F. Neurath, Andreas E. Kremer   +7 more
doaj   +1 more source

Estradiol treatment prevents injury induced enhancement in spinal cord dynorphin expression.

Frontiers in Physiology, 2012
Administration of the ovarian steroid estradiol in male and female animals has been shown to have neuromodulatory and neuroprotective effects in a variety of experimental models. In the present study, spinal tissues from dermatomes just above (T5-7, at
Daya S. Gupta, Charles H. Hubscher
doaj   +1 more source

Bulleyaconitine A Inhibits Visceral Nociception and Spinal Synaptic Plasticity through Stimulation of Microglial Release of Dynorphin A

Neural Plasticity, 2020
Background. Visceral pain is one of the most common types of pain and particularly in the abdomen is associated with gastrointestinal diseases. Bulleyaconitine A (BAA), isolated from Aconitum bulleyanum, is prescribed in China to treat chronic pain.
Sheng-Nan Huang, Jinbao Wei, Lan-Ting Huang, Pei-Jun Ju, Jinghong Chen, Yong-Xiang Wang   +5 more
doaj   +1 more source

Ginsenoside Re protects methamphetamine-induced dopaminergic neurotoxicity in mice via upregulation of dynorphin-mediated κ-opioid receptor and downregulation of substance P-mediated neurokinin 1 receptor

Journal of Neuroinflammation, 2018
Background We previously reported that ginsenoside Re (GRe) attenuated against methamphetamine (MA)-induced neurotoxicity via anti-inflammatory and antioxidant potentials.
Duy-Khanh Dang, Eun-Joo Shin, Dae-Joong Kim, Hai-Quyen Tran, Ji Hoon Jeong, Choon-Gon Jang, Seung-Yeol Nah, Jung Hwan Jeong, Jae Kyung Byun, Sung Kwon Ko, Guoying Bing, Jau-Shyong Hong, Hyoung-Chun Kim   +12 more
doaj   +1 more source

Basal ganglia neuropeptides show abnormal processing associated with L-DOPA-induced dyskinesia

npj Parkinson's Disease, 2022
L-DOPA administration is the primary treatment for Parkinson’s disease (PD) but long-term administration is usually accompanied by hyperkinetic side-effects called L-DOPA-induced dyskinesia (LID). Signaling neuropeptides of the basal ganglia are affected
Heather Hulme, Elva Fridjonsdottir, Theodosia Vallianatou, Reza Shariatgorji, Anna Nilsson, Qin Li, Erwan Bezard, Per E. Andrén   +7 more
doaj   +1 more source

Behavioral effects of dynorphin — a novel opioid neuropeptide [PDF]

Neuropharmacology, 1980
Abstract Adult male Swiss-Webster mice were implanted with permanently indwelling cannulae with tips within the lateral cerebral ventricle. The neuropeptide dynorphin was infused centrally and subjects were tested on a variety behavioral tasks. Peptide treated mice were more likely than vehicle treatd mice to eat and groom. At higher doses, dynorphin
openaire   +3 more sources