Results 31 to 40 of about 22,550,361 (272)

Identification of dynorphin a from zebrafish: A comparative study with mammalian dynorphin A

open access: yesNeuroscience, 2007
We report the cloning and molecular characterization of the zfPDYN. The complete open reading frame for this propeptide is comprised in two exons that are localized on chromosome 23. zfPDYN cDNA codes for a polypeptide of 252 amino acids that contains the consensus sequences for four opioid peptides: an Ile-enkephalin, the neo-endorphins, dynorphin A ...
E. Marrón Fernández de Velasco   +6 more
openaire   +4 more sources

Dynorphin and the pathophysiology of drug addiction [PDF]

open access: yesPharmacology & Therapeutics, 2007
Drug addiction is a chronic relapsing disease in which drug administration becomes the primary stimulus that drives behavior regardless of the adverse consequence that may ensue. As drug use becomes more compulsive, motivation for natural rewards that normally drive behavior decreases. The discontinuation of drug use is associated with somatic signs of
Vladimir I. Chefer   +2 more
openaire   +3 more sources

Opioid Receptors in Immune and Glial Cells-Implications for Pain Control [PDF]

open access: yes, 2020
Opioid receptors comprise μ (MOP), δ (DOP), κ (KOP), and nociceptin/orphanin FQ (NOP) receptors. Opioids are agonists of MOP, DOP, and KOP receptors, whereas nociceptin/orphanin FQ (N/OFQ) is an agonist of NOP receptors.
Celik, Melih Ö., Machelska, Halina
core   +1 more source

Dynorphin A analogs for the treatment of chronic neuropathic pain.

open access: yesFuture Medicinal Chemistry, 2016
Chronic pain is one of the most ubiquitous diseases in the world, but treatment is difficult with conventional methods, due to undesirable side effects of treatments and unknown mechanisms of pathological pain states.
S. M. Hall, Y. Lee, V. Hruby
semanticscholar   +1 more source

Identifying functional populations among the interneurons in laminae I-III of the spinal dorsal horn [PDF]

open access: yes, 2017
The spinal dorsal horn receives input from primary afferent axons, which terminate in a modality-specific fashion in different laminae. The incoming somatosensory information is processed through complex synaptic circuits involving excitatory and ...
Todd, Andrew J.
core   +1 more source

Elevated mutant dynorphin A causes Purkinje cell loss and motor dysfunction in spinocerebellar ataxia type 23.

open access: yesBrain : a journal of neurology, 2015
Spinocerebellar ataxia type 23 is caused by mutations in PDYN, which encodes the opioid neuropeptide precursor protein, prodynorphin. Prodynorphin is processed into the opioid peptides, α-neoendorphin, and dynorphins A and B, that normally exhibit opioid-
C. Smeets   +14 more
semanticscholar   +1 more source

Ad libitum feeding triggers puberty onset associated with increases in arcuate Kiss1 and Pdyn expression in growth-retarded rats

open access: yesThe Journal of Reproduction and Development, 2019
Increasing evidence shows that puberty onset is largely dependent on body weight rather than chronological age. To investigate the mechanism involved in the energetic control of puberty onset, the present study examined effects of chronic food ...
Sutisa MAJARUNE   +6 more
doaj   +1 more source

Pharmacology of Kappa Opioid Receptors: Novel Assays and Ligands

open access: yesFrontiers in Pharmacology, 2022
The present study investigated the in vitro pharmacology of the human kappa opioid receptor using multiple assays, including calcium mobilization in cells expressing chimeric G proteins, the dynamic mass redistribution (DMR) label-free assay, and a ...
Chiara Sturaro   +11 more
doaj   +1 more source

Projection neurons in lamina III of the rat spinal cord are selectively innervated by local dynorphin-containing excitatory neurons [PDF]

open access: yes, 2012
Large projection neurons in lamina III of the rat spinal cord that express the neurokinin 1 receptor are densely innervated by peptidergic primary afferent nociceptors and more sparsely by low-threshold myelinated afferents. However, we know little about
Baseer, N.   +5 more
core   +1 more source

The opioid peptide dynorphin A induces leukocyte responses via integrin Mac-1 (αMβ2, CD11b/CD18)

open access: yesMolecular Pain, 2015
BackgroundOpioid peptides, including dynorphin A, besides their analgesic action in the nervous system, exert a broad spectrum of effects on cells of the immune system, including leukocyte migration, degranulation and cytokine production.
Nataly P. Podolnikova   +2 more
semanticscholar   +1 more source

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