Results 51 to 60 of about 120,854,643 (210)

Opioid Modulation of Major Neurotransmitter Systems: Acute, Chronic, and Withdrawal Effects

European Journal of Neuroscience, Volume 64, Issue 9, November 2026.
Opioids are widely used but also frequently misused drugs that affect multiple neurotransmitter systems, including dopaminergic, glutamatergic, GABAergic, serotonergic, and cholinergic pathways. Opioid‐induced neuroadaptations depend on the duration of drug exposure, with distinct changes also emerging following drug discontinuation.
Daniela Novakova, Eliska Pritulova, Jiri Novotny   +2 more
wiley   +1 more source

Dynorphin Binds to P. aeruginosa In Vitro, and Enters the Bacterial Cell Cytoplasm

, 2013
(A–C) Binding of dynorphin to P. aeruginosa; (A) negative control demonstrating no dynorphin staining when cells were not incubated with dynorphin; (B) negative control demonstrating no dynorphin staining when cell were incubated with dynorphin but ...
Gaoping Xiao (210986), John C Alverdy (40811), Mae Ciancio (379103), Elaine Petroff (379105), Jerrold R Turner (40810), Laurence G Rahme (45402), Olga Zaborina (40802), Yimei Chen (40804), Terry Li (379102), Vesta Valuckaite (139751), Alex Zaborin (379104), Eugene Chang (180832), Francois Lepine (3215901)   +12 more
core   +1 more source

Arcuate kisspeptin neurons display two types of calcium events: Regulation by sex, gonads, and senktide

Journal of Neuroendocrinology, Volume 38, Issue 11, November 2026.
Abstract The pattern of gonadotropin‐releasing hormone (GnRH) release controls reproduction in vertebrates and is regulated by feedback from the gonads. Evidence is accumulating that steroid‐sensitive hypothalamic arcuate kisspeptin–neurokinin B–dynorphin (KNDy) neurons drive GnRH pulses.
R. Anthony DeFazio, Christian R. Burgess, Laura L. Burger, Amanda G. Gibson, Suzanne M. Moenter   +4 more
wiley   +1 more source

Endogenous dynorphin protects against neurotoxin-elicited nigrostriatal dopaminergic neuron damage and motor deficits in mice

Journal of Neuroinflammation, 2012
Background The striato-nigral projecting pathway contains the highest concentrations of dynorphin in the brain. The functional role of this opioid peptide in the regulation of mesencephalic dopaminergic (DAergic) neurons is not clear.
Wang Qingshan, Shin Eun-Joo, Nguyen Xuan-Khanh, Li Quan, Bach Jae-Hyung, Bing Guoying, Kim Won-Ki, Kim Hyoung-Chun, Hong Jau-Shyong   +8 more
doaj   +1 more source

Recent advances in polyendocrine metabolic ovarian syndrome, formerly polycystic ovary syndrome, with emphasis on endocrine and metabolic dysfunction and cardiovascular risk

Journal of Internal Medicine, Volume 300, Issue 5, Page 590-609, November 2026.
Abstract Polyendocrine metabolic ovarian syndrome (PMOS), previously known as polycystic ovary syndrome, affects 10%–13% of women of reproductive age and remains underdiagnosed despite its substantial health burden. The introduction of the new PMOS nomenclature in 2026 reflects a fundamental shift in understanding the condition as a lifelong endocrine ...
Maria Forslund, Johanna Melin, Anju E. Joham, Terhi T. Piltonen, D. Aled Rees, Helena J. Teede   +5 more
wiley   +1 more source

of induction of persistent nociception by dynorphin [PDF]

, 1996
The opioid peptide dynorphin has been demonstrated to be both nociceptive and antinociceptive. This article will review the potential mechanisms through which dynorphin contributes to spinally mediated nociception.
George L Wilcox, Alice A Larson, Tinna M Laughlin   +2 more
core  

The right temperature at the right time: A framework for understanding thermoregulatory pathophysiology in Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 10, October 2026.
Abstract The neuromodulatory subcortical system (NSS) includes thermoregulatory neurons that maintain core body temperature (Tb) and brain temperature within a narrow, diurnally varying range. Cellular pathways in NSS neurons implicated in Alzheimer's disease (AD) may be vulnerable to Tb rhythm disturbance because of their sensitivity to temperature ...
Esther Blessing
wiley   +1 more source

Label-free, real-time monitoring of membrane binding events at zeptomolar concentrations using frequency-locked optical microresonators

Nature Communications
G-protein coupled receptors help regulate cellular function and communication, and are targets of small molecule drug discovery efforts. Conventional techniques to probe these interactions require labels and large amounts of receptor to achieve ...
Adley Gin, Phuong-Diem Nguyen, Jeffrey E. Melzer, Cheng Li, Hannah Strzelinski, Stephen B. Liggett, Judith Su   +6 more
doaj   +1 more source

Does the kappa opioid receptor system contribute to pain aversion?

Frontiers in Pharmacology, 2014
The kappa opioid receptor (KOR) and the endogenous peptide-ligand dynorphin have received significant attention due the involvement in mediating a variety of behavioral and neurophysiological responses, including opposing the rewarding properties of ...
Catherine M Cahill, Catherine M Cahill, Catherine M Cahill, Anna MW Taylor, Anna MW Taylor, Christopher P Cook, Edmund W Ong, Edmund W Ong, Jose A Moron, Christopher J Evans   +9 more
doaj   +1 more source

Same Fat, Different Consequences? The Association Between Fat Distribution and Vasomotor Menopausal Symptoms Varies by Menopausal Status

Comprehensive Physiology, Volume 16, Issue 5, October 2026.
Body fat distribution was associated with vasomotor symptoms in a menopausal stage‐specific manner. Greater trunk and abdominal adiposity were linked to more frequent and bothersome symptoms during perimenopause, whereas distinct abdominal adiposity measures showed contrasting associations with symptom burden after menopause.
Katarzyna Górecka, Monika Krzyżanowska
wiley   +1 more source