Results 71 to 80 of about 120,854,643 (210)

Proopiomelanocortin (POMC)–β‐Endorphin System in the Rat Colon: Expression, Up Regulation by Stress, and Correlation With Stress‐Induced Visceral Analgesia

Neurogastroenterology &Motility, Volume 38, Issue 10, October 2026.
This study identified a functional proopiomelanocortin–β‐endorphin system in the rat colon. Peripheral CRF and repeated water avoidance stress increased colonic POMC expression, which was associated with reduced visceral pain. These findings suggest that, outside the pituitary, a CRF‐ and stress‐sensitive enteric POMC–β‐endorphin system may help ...
Pu‐Qing Yuan, Muriel Larauche, Vincent Wu, Yvette Taché   +3 more
wiley   +1 more source

High-frequency stimulation-induced peptide release synchronizes arcuate kisspeptin neurons and excites GnRH neurons

eLife, 2016
Kisspeptin (Kiss1) and neurokinin B (NKB) neurocircuits are essential for pubertal development and fertility. Kisspeptin neurons in the hypothalamic arcuate nucleus (Kiss1ARH) co-express Kiss1, NKB, dynorphin and glutamate and are postulated to provide ...
Jian Qiu, Casey C Nestor, Chunguang Zhang, Stephanie L Padilla, Richard D Palmiter, Martin J Kelly, Oline K Rønnekleiv   +6 more
doaj   +1 more source

Menopausal hormone therapy and comprehensive postmenopausal care in gynecologic cancer survivors: A position paper from the FIGO Committee on Women at Menopausal Age

International Journal of Gynecology &Obstetrics, Volume 174, Issue 3, Page 1151-1171, September 2026.
Abstract Recent advances in cancer screening, diagnosis, and treatment have greatly improved survival rates among women with gynecologic cancers. More survivors now live long enough to experience treatment‐related menopause. Vasomotor symptoms, genitourinary syndrome of menopause, sexual dysfunction, sleep issues, and long‐term risks from estrogen ...
Agnaldo Lopes da Silva‐Filho, Suvarna Khadilkar, Hema Divakar, Chiara Benedetto, Andrea R. Genazzani, Diana Ramos, Elizabete Argale, Enrique Herrera, Martha Hickey   +8 more
wiley   +1 more source

Mechanism of elevated LH/FSH ratio in lean PCOS revisited: a path analysis

Scientific Reports
Polycystic ovary syndrome (PCOS) is the most common endocrine disorder affecting 5–20% of reproductive-age women. However, the treatment of PCOS is mainly based on symptoms and not on its pathophysiology.
Gita Pratama, Budi Wiweko, Asmarinah, Indah S. Widyahening, Trinovita Andraini, Hartanto Bayuaji, Andon Hestiantoro   +6 more
doaj   +1 more source

Dynorphin-dependent reduction of excitability and attenuation of inhibitory afferents of NPS neurons in the pericoerulear region of mice

Frontiers in Cellular Neuroscience, 2016
The Neuropeptide S system, consisting of the 20-amino acid peptide neuropeptide S (NPS) and its G-protein coupled receptor (NPSR), modulates arousal, wakefulness, anxiety, and fear-extinction in mice.
Kay eJuengling, Peter eBlaesse, Lena eGoedecke, Hans-Christian ePape   +3 more
doaj   +1 more source

Dynorphin, naloxone, and overflow of norepinephrine during cardiac nerve stimulation in dogs

, 1992
The effects of dynorphin-(1-9) and naloxone on norepinephrine (NE) overflow and myocardial contractility were determined during left cardiac nerve stimulation in the anesthetized dog.
J. L. Caffrey, B. A. Barron, H. Gu, J. F. Gaugl   +3 more
core   +1 more source

Electrophysiological effects of dynorphin peptides on hippocampal pyramidal cells in rat [PDF]

, 1985
Single-unit extracellular recording was carried out in rats to characterize the effects of dynorphin and several structurally related peptides on hippocampal pyramidal cell activity.
Moises, Hylan C., Michael Walker, J.
core   +1 more source

Bradykinin Receptors Mediate Dynorphin Pronociceptive Action To Produce Persistent Pain

, 2007
Intrathecal injection of dynorphin or des-Tyr-dynorphin fragments, which do not bind to opioid receptors, produce tactile and thermal hypersensitivity in rodents.
Chen, Qingmin
core   +2 more sources

Isotalatizidine, a C19-diterpenoid alkaloid, attenuates chronic neuropathic pain through stimulating ERK/CREB signaling pathway-mediated microglial dynorphin A expression

Journal of Neuroinflammation, 2020
Background Isotalatizidine is a representative C19-diterpenoid alkaloid extracted from the lateral roots of Aconitum carmichaelii, which has been widely used to treat various diseases on account of its analgesic, anti-inflammatory, anti-rheumatic, and ...
Shuai Shao, Huan Xia, Min Hu, Chengjuan Chen, Junmin Fu, Gaona Shi, Qinglan Guo, Yu Zhou, Wenjie Wang, Jiangong Shi, Tiantai Zhang   +10 more
doaj   +1 more source

Dynorphin: friend or foe?

Pain, 2000
Pain 87 (2000) 235-239. doi:10.1016/S0304-3959(00)00360-2 ; Received by publisher: 2000-05-22 ; Harvest Date: 2016-01-04 12:22:07 ; DOI:10.1016/S0304-3959(00)00360-2 ; Page Range: 235 ...
Department of Oral Surgery, Division of Neuroscience, University of Florida College of Dentistry, P.O. Box 100416, Gainesville, FL 32610, USA ( host institution ), Caudle, Robert M. ( author ), Mannes, Andrew J. ( author )   +2 more
openaire   +3 more sources