Results 141 to 150 of about 6,457 (202)

The protein kinase DYRK1B is a p53 target gene and functions as a negative feedback regulator of the transcription factor RFX7. [PDF]

Cell Death Dis
Wilms G, Schwandt K, Düsterhöft S, Helmich P, Wozniak J, Kraft F, Kallabis S, Meissner F, Becker W.   +8 more
europepmc   +1 more source

Emerging Strategies to Inhibit the G1/S Transition for Cancer Therapy. [PDF]

Cancer Res
Rubin SM, Sage J, Skotheim JM.
europepmc   +1 more source

ZRMQ-22, a novel DYRK1A inhibitor, attenuates neuroinflammation and cognitive impairments in LPS-induced mice: a potential strategy for Alzheimer's disease. [PDF]

RSC Med Chem
Ren M, Chen H, Li Z, Zhuang J, Yang A, Li X, Li X, Wang X, Xu Z, Liu X, Song J, Jiang T, Xu Z, Gao X, Zhao Q.   +14 more
europepmc   +1 more source

Pharmacokinetics, distribution, metabolism, excretion and safety characterization of ZJCK-6-72: novel DYRK1A inhibitor with optimized brain exposure for Alzheimer's disease therapy. [PDF]

Front Pharmacol
Li Z, Chen H, Li X, Yang A, Wang X, Liu S, Ning X, Zhou L, Zheng F, Xun F, Hu B, Cui Y, Yao D, Gao X, Xu Z, Zhao Q.   +15 more
europepmc   +1 more source

Targeting dual specificity tyrosine-phosphorylation-regulated kinase 1A mitigates tauopathy and enhances recovery after repetitive head injury. [PDF]

Neurotherapeutics
Melchior B, Browning M, McCartan R, Lai C, Hahn-Townsend C, Gratkowski A, Morin A, Mullan M, Crawford F, Grifman M, Mouzon B.   +10 more
europepmc   +1 more source

Critical role of the CMGC insert sequence for tyrosine autophosphorylation in the protein kinase DYRK1B. [PDF]

Sci Rep
Detro-Dassen S, Schwandt K, Helmich P, Düsterhöft S, Becker W.   +4 more
europepmc   +1 more source

Single-cell profiling reveals FAM117A as a key regulator linking macrophage-epithelial crosstalk with the progression of lung adenocarcinoma. [PDF]

Exp Hematol Oncol
Wu C, Ren Z, Che G, Liu H, Tao H, Li D, Wang J, Hou X, Hu Y.   +8 more
europepmc   +1 more source

Promoting Research Excellence in Down Syndrome: Proceedings of the 5th International Conference of the Trisomy 21 Research Society. [PDF]

Neuromolecular Med
Di Domenico F, Perluigi M, Tramutola A, Bacalini MG, Balduino Victorino D, Barroeta I, Bartesaghi R, Carfi A, Carmona-Iragui M, Cohen AD, Costa ACS, Costanzo F, Dierssen M, Dunn L, Emili M, Evans EJ, Farrell C, Flores-Aguilar L, Fukami-Gartner A, Gimenez S, Granholm AC, Hilgenkamp T, Izzo A, Krinsky-McHale SJ, Del Hoyo Soriano L, Meijer L, Mobley B, Moskowitz IP, Nizetic D, Pierce J, Ptomey LT, Rachubinski AL, Rebillat AS, Roper R, Santoro JD, Skotko BG, Stagni F, Strydom A, Valay L, Zaman S, Zampieri BL, Trisomy 21 Research Society Executive Board, Potier MC, Barone E.   +43 more
europepmc   +1 more source

CMGC Kinases in Viral Infection and Human Disease. [PDF]

Pathogens
Amusan OT, Guo H.
europepmc   +1 more source

Geometry-based BERT: An experimentally validated deep learning model for molecular property prediction in drug discovery. [PDF]

J Pharm Anal
Zhang X, Qian C, Yang B, Jin H, Wu S, Xia J, Yang F, Zhang L.   +7 more
europepmc   +1 more source