Vascular defects of DYRK1A knockouts are ameliorated by modulating calcium signaling in zebrafish
Disease Models & Mechanisms, 2019 DYRK1A is a major causative gene in Down syndrome (DS). Reduced incidence of solid tumors such as neuroblastoma in DS patients and increased vascular anomalies in DS fetuses suggest a potential role of DYRK1A in angiogenic processes, but in vivo evidence
Hyun-Ju Cho +8 more
doaj +1 more source
Bioactive Marine Drugs and Marine Biomaterials for Brain Diseases [PDF]
, 2014 Marine invertebrates produce a plethora of bioactive compounds, which serve as inspiration for marine biotechnology, particularly in drug discovery programs and biomaterials development.
Andrade, Paula B. +3 more
core +2 more sources
Evaluation of the Effects of Green Tea Extracts on Bone Homeostasis in the Ts65Dn Down Syndrome Mouse Model [PDF]
, 2013 poster abstractDown Syndrome (DS) is a genetic disorder that affects ~1 in 700 live births, caused by trisomy of human chromosome 21 (Hsa21), and results in cognitive impairment, craniofacial abnormalities, low muscle tone, and skeletal deficiencies ...
Abeysekera, Irushi S. +3 more
core
Deciphering DYRK1A Signaling using Proteomics and Transcriptomics
The FASEB Journal, 2018 Trisomy 21 is the most common genetic manifestation of intellectual disability, with deleterious brain phenotypes thought to be caused by increased dosage of critical genes on chromosome 21, including the kinase DYRK1A. Additionally, individuals with Down syndrome are at an increased risk of developing Alzheimer's disease, immune dysfunction and ...
Zachary Poss +5 more
openaire +1 more source
Correction of cerebellar movement related deficits by normalizing Dyrk1a copy number in the Ts65Dn mouse model for Down syndrome [PDF]
, 2016 poster abstractElucidation of the underlying mechanisms involved in brain related deficits of Down syndrome (DS) would be useful for consideration of therapeutic interventions.
Abeysekera, Irushi +4 more
core
Clinical and Experimental HypertensionPulmonary arterial hypertension (PAH) is characterized by progressive vascular remodeling caused by the excessive proliferation and survival of pulmonary artery smooth muscle cells (PASMCs).
Cong Lan +5 more
doaj +1 more source
DYRK1A-related intellectual disability syndrome
Česko-slovenská pediatrie, 2022 Kateřina Slabá +7 more
openaire +1 more source
DYRK1A-mediated Hyperphosphorylation of Tau [PDF]
Journal of Biological Chemistry, 2007 Soo-Ryoon Ryoo +10 more
openaire +1 more source
Effects of EGCG treatment on deficits in a radial-arm maze spatial pattern separation task in a Down syndrome mouse model [PDF]
, 2015 poster abstractDown syndrome (DS) is caused by three copies of human chromosome 21 (Hsa 21) and results in a constellation of phenotypes that include intellectual disability.
Abeysekera, Irushi +6 more
core
EGCG Treatment on Ts65Dn Mice Suggests a Possible Correlation in Cognitive Development Deficit Reduction [PDF]
, 2014 poster abstractDown syndrome (DS) is caused by trisomy of human chromosome 21 (Ts21), affecting 1 in 700 live births. Ts21 results in about 80 phenotypes of which intellectual disability (ID) is one of the most debilitating.
Abeysekera, Irushi S. +2 more
core