Results 111 to 120 of about 9,925 (218)
Structural mechanisms of DREAM complex assembly and regulation [PDF]
, 2015 The DREAM complex represses cell cycle genes during quiescence through scaffolding MuvB proteins with E2F4/5 and the Rb tumor suppressor paralog p107 or p130.
Felthousen, Jessica G. +5 more
core +2 more sources
Journal of Enzyme Inhibition and Medicinal ChemistryDual-specificity tyrosine-regulated kinase 1 A (DYRK1A) is crucial in neurogenesis, synaptogenesis, and neuronal functions. Its dysregulation is linked to neurodegenerative disorders like Down syndrome and Alzheimer’s disease. Although the development of
Huang-Ju Tu +10 more
doaj +1 more source
Analysis of diverse signal transduction pathways using the genetic model system Caenorhabditis elegans [PDF]
, 2003 Signal transduction allows cells to respond to signals from their environment and is therefore important for most biological processes. The binding of an extracellular signalling molecule to a cell-surface receptor is the first step in most signal ...
Moorman, Celine
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Effects of the Calcineurin/NFAT Pathway in Skeletal Abnormalities Associated with Down Syndrome [PDF]
, 2015 poster abstractDown Syndrome (DS) is a genetic disorder caused by trisomy of human chromosome 21 (Hsa21). DS phenotypes include cognitive impairment, craniofacial abnormalities, and skeletal deficiencies.
Patel, Rushiv +2 more
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Identification and evaluation of novel prognostic genetic markers for childhood acute lymphoblastic leukemia [PDF]
, 2017 Childhood acute lymphoblastic leukemia (ALL) is the most common form of childhood cancer today. Due to advances in risk stratification and treatment, survival rates have increased drastically the last decades. Currently, children with acute leukemia in
Ivanov Öfverholm, Ingegerd
core +1 more source
Green tea polyphenols rescue of brain defects induced by overexpression of DYRK1A.
PLoS ONE, 2009 Individuals with partial HSA21 trisomies and mice with partial MMU16 trisomies containing an extra copy of the DYRK1A gene present various alterations in brain morphogenesis.
Fayçal Guedj +10 more
doaj +1 more source
ERK Signals: Scaffolding Scaffolds? [PDF]
, 2016 ERK1/2 MAP Kinases become activated in response to multiple intra- and extra-cellular stimuli through a signaling module composed of sequential tiers of cytoplasmic kinases. Scaffold proteins regulate ERK signals by connecting the different components of
Casar, Berta, Crespo, Piero
core +2 more sources
DYRK1A Controls HIV-1 Replication at a Transcriptional Level in an NFAT Dependent Manner.
PLoS ONE, 2015 BackgroundTranscription of the HIV-1 provirus is regulated by both viral and host proteins and is very important in the context of viral latency. In latently infected cells, viral gene expression is inhibited as a result of the sequestration of host ...
Thijs Booiman +4 more
doaj +1 more source
PLoS ONE, 2009 BackgroundHyperhomocysteinemia, characterized by increased plasma homocysteine level, is associated with an increased risk of atherosclerosis. On the contrary, patients with Down syndrome appear to be protected from the development of atherosclerosis. We
Christophe Noll +15 more
doaj +1 more source
Effects of Epigallocatechin-3-gallate Treatment on Cognitive Deficits in a Down Syndrome Mouse Model [PDF]
, 2014 poster abstractDown syndrome (DS) is caused by three copies of human chromosome 21 (Hsa21) and results in a constellation of phenotypes that include intellectual disability (ID) and skeletal abnormalities.
Abeysekera, Irushi S. +2 more
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