Results 111 to 120 of about 6,457 (202)

Design Synthesis and Biological Evaluation of DYRK1A Inhibitors [PDF]

, 2017
DYRK1A is a dual-specificity protein kinase that catalyses not only autophosphorylation on its tyrosine residue but the phosphorylation of serine and threonine residues in its substrates.
Zhou, Qingqing
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NFATc1 mutants abolished the effects of DYRK1A.

, 2017
A. Nine mutant constructs of NFATc1 were co-transfected with pCMV-DYRK1A in HEK293 cells. B. HEK293 cells co-transfected with NFATc1 and nine mutant constructs of NFATc1 were treated with proteasome inhibitor lactacystin (5uM) for 24 hours after ...
Yuankai Zhang (3779878), Heng Liu (293917), Qian Sun (53880), Shuai Chen (506142), Long Chen (315739), Xiulian Sun (573264), Ketao Wang (3779881)   +6 more
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Investigation of the DYRK1A Regulation by LZTS2-SIPA1L1 Complex

, 2023
A region on chromosome 21, the Down Syndrome critical region (DSCR), is associated with major defects found in Down Syndrome, such as craniofacial malformations.
Litovchick, Larisa, M.D.,Ph.D., Gunnin, Rebecca, Witt, Austin, B.S.   +2 more
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Charakterisierung der Proteinkinase DYRK1A : Substrat- und Autophosphorylierung

, 2005
The Dual Specificity YAK1p-Related Kinase1A (DYRK1A) encodes an evolutionary highly conserved protein kinase. Due to different animal models and its genomic localisation on human chromosome 21, is it considered a candidate gene in mental retardation of ...
Himpel, Sunke
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DYRK1A-mediated Hyperphosphorylation of Tau [PDF]

Journal of Biological Chemistry, 2007
Soo-Ryoon Ryoo, Hey Kyeong Jeong, Chinzorig Radnaabazar, Jin-Ju Yoo, Hyun-Jeong Cho, Hye-Won Lee, In-Sook Kim, Young-Hee Cheon, Young Soo Ahn, Sul-Hee Chung, Woo-Joo Song   +10 more
openaire   +1 more source

Interneuron migration defects during corticogenesis contribute to Dyrk1a haploinsufficiency syndrome pathogenesis

International audienceInterneuron development is a crucial step of brain corticogenesis. When affected it often leads to brain dysfunctions like epilepsy, intellectual disabilities and autism spectrum disorder.
Nalesso, Valérie, Artot, Victorine, Nguyen, Thu, Lan, Muniz Moreno, Maria del Mar, Dubos, Aline, Birling, Marie-Christine, Brault, Véronique, Tilly, Peggy, Godin, Juliette, Herault, Yann, Rudolf, Gabrielle, Hinckelmann, Maria Victoria   +11 more
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MicroRNA-221-3p inhibits the inflammatory response of keratinocytes by regulating the DYRK1A/STAT3 signaling pathway to promote wound healing in diabetes

Communications Biology
Diabetic foot ulcer (DFU), a serious complication of diabetes, remains a clinical challenge. MicroRNAs affect inflammation and may have therapeutic value in DFU.
Keyan Hu, Lei Liu, Songtao Tang, Xin Zhang, Hongfeng Chang, Wenyang Chen, Taotao Fan, Lesha Zhang, Bing Shen, Qiu Zhang   +9 more
doaj   +1 more source

DYRK1A wt Allele [PDF]

, 2020
openaire   +1 more source

Molecular Mechanisms of the DYRK1A-regulated DNA Repair

, 2020
Molecular Mechanisms of the DYRK1A-regulated DNA Repair Polina Bukina, Dept. of Biology, with Dr. Sarah Golding, Dept. of Biology The functions of human Dual-specificity tyrosine (Y)-Regulated Kinase 1A, or DYRK1A, include cell cycle control and ...
Bukina, Polina, Ananthapadmanabhan, Varsha   +1 more
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Exploring the role of DYRK1A in RNA polymerase III transcription : DYRK1A as a potential regulator of TFIIIC

The kinase DYRK1A (dual-specificity tyrosine-regulated kinase 1A) is a dosage-sensitive gene, since both haploinsufficiency and overexpression when in trisomy lead to pathological phenotypes in humans.
Cort, Rianne Angelica
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