Results 91 to 100 of about 6,457 (202)
DYRK1A modulates fear memory formation via epigenetic modification
Molecular BrainFear memory formation is crucial for survival, with the hippocampus playing a central role. This study investigates the behavioral and molecular aspects of fear memory formation, focusing on Dual-specificity tyrosine phosphorylation-regulated kinase 1 A (
Dae-Si Kang, Ja Wook Koo
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, 2014 Western blot analysis of Dyrk1A protein levels in the hippocampus of CO +/+, TS +/+/+ and TS +/+/− mice. Differences in the TS +/+/+ and TS +/+/− mice are expressed relative to the values of CO +/+ mice (defined as 100%). ANOVA ‘trisomy’: F(1,17) = 22.79,
Paula Martínez (3243618) +8 more
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The role of Goldilocks protein kinase DYRK1A in embryonic development. [PDF]
Dev BiolDYRK1A (Dual-specificity Tyrosine (Y) Regulated Kinase) is a dosage sensitive gene where too much or too little of its “Goldilocks” protein product can result in structural birth defects. DYRK1A loss of function variants are associated with DYRK1A syndrome, which is characterized by intellectual disability and stereotypical ...
Johnson HK +2 more
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DYRK1A overexpression reduces the NGF effect on PAI-1 expression.
, 2013 PC12 cells that allow conditional overexpression of DYRK1A under the control of doxycyclin were generated. DYRK1A overexpression was induced by treating the cells with doxycyclin overnight. Cells were treated with NGF (50 ng/ml) for 2.5 h (C) or for 3 h (
Ulf Soppa (426606) +3 more
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Dyrk1A expression at the neuromuscular junctions.
, 2013 A) Dyrk1A (red) was found in neuromuscular synapses, where it was not co-localized with α-bungarotoxin (αBtx; green) in wild type (upper panel) and TgDyrk1A (middle panel) mice, indicating that Dyrk1A is located in the presynaptic region.
Anna Casanovas (288523) +2 more
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One-carbon cycle alterations induced by Dyrk1a dosage
Molecular Genetics and Metabolism Reports, 2014 Hyperhomocysteinemia due to cystathionine beta synthase deficiency confers diverse clinical manifestations. It is characterized by elevated plasma homocysteine levels, a common amino acid metabolized by remethylation to methionine or transsulfuration to ...
Jean-Maurice Delabar +8 more
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DYRK1A Controls HIV-1 Replication at a Transcriptional Level in an NFAT Dependent Manner.
PLoS ONE, 2015 BackgroundTranscription of the HIV-1 provirus is regulated by both viral and host proteins and is very important in the context of viral latency. In latently infected cells, viral gene expression is inhibited as a result of the sequestration of host ...
Thijs Booiman +4 more
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Effect of DYRK1A on PC12 differentiation.
, 2013 Differentiation of PC12 cells that conditionally overexpress DYRK1A was induced as described in the methods section by treatment with NGF (50 ng/ml) for 48 h in the presence or absence of doxycycline.
Ulf Soppa (426606) +3 more
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Frontiers in NeuroscienceNucleotide excision repair (NER) disorders are genetic conditions caused by defects in the pathway responsible for repairing DNA lesions due to UV radiation. These defects lead to a variety of heterogeneous disorders, including Cockayne syndrome (CS) and
Nicolas Le May +16 more
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PLoS ONE, 2009 BackgroundHyperhomocysteinemia, characterized by increased plasma homocysteine level, is associated with an increased risk of atherosclerosis. On the contrary, patients with Down syndrome appear to be protected from the development of atherosclerosis. We
Christophe Noll +15 more
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