Results 71 to 80 of about 6,457 (202)
Alzheimer's &Dementia, Volume 22, Issue 5, May 2026.Abstract INTRODUCTION Down syndrome (DS) is the leading genetic cause of intellectual disability and Alzheimer's disease (AD), with over 90% of individuals developing AD‐related dementia (DSAD). The triplication of the APP gene on chromosome 21 drives early amyloid‐β (Aβ) accumulation, but other Hsa21 genes also contribute to pathology.
Monika Rataj Baniowska +18 more
wiley +1 more source
PLoS ONE, 2014 Acute myeloid leukemia (AML), caused by abnormal proliferation and accumulation of hematopoietic progenitor cells, is one of the most common malignancies in adults.
Qiang Liu +6 more
doaj +1 more source
ChemistryEurope, Volume 4, Issue 5, May 2026.Ceramidonines, benzo‐fused 3,9‐diazaperylenes and related compounds were synthesized, and their properties studied. Substituted ceramidonines were synthesized by cyclization of 1‐(arylamino)anthraquinones under acidic conditions. These key intermediates were prepared either by copper‐promoted N‐arylation of 1‐aminoanthraquinone with iodoarenes or, more
Ahlem N. Khelf‐Maghraoui +15 more
wiley +1 more source
DYRK1A in cancer: good or evil? : Defining properties of DYRK1A kinase as a novel tumor driver
, 2021 DYRK (dual-specificity tyrosine-regulated kinases) is an evolutionary conserved family of protein kinases involved in the regulation of cellular processes, such as proliferation and survival, which play pivotal role in tumor development.
Boni, Jacopo, 1987-
core
Journal of Biomedical Science, 2022 Background Hepatocellular carcinoma (HCC) accounts for the majority of liver cancer cases, while metastasis is considered the leading cause of HCC-related death.
Yang-ling Li +7 more
doaj +1 more source
Advanced Science, Volume 13, Issue 23, 23 April 2026.We identify an antagonistic ubiquitin circuit that controls cellular permissiveness to multiple coronaviruses. The deubiquitinase USP7 stabilizes the epigenetic regulator KDM6A to upregulate viral receptors, while the E3 ligase RNF40 degrades KDM6A by catalyzing K6/K11‐ubiquitin chains of KDM6A for autophagic degradation.
Meng‐Zhuo Huang +9 more
wiley +1 more source
Case Report: Gut and spleen anomalies associated with DYRK1A syndrome
DYRK1A syndrome has been extensively studied primarily with regard to neurologic and other phenotypic features such as skeleton and craniofacial alterations. In the present paper, we aim to highlight unusual anomalies associated with a DYRK1A mutation: a
Tocchioni, F. +5 more
core +1 more source
Use of anti–amyloid‐β monoclonal antibodies in persons with Down syndrome Alzheimer's disease
Alzheimer's &Dementia, Volume 22, Issue 4, April 2026.Abstract INTRODUCTION The recent development and licensing of anti–amyloid‐β monoclonal antibodies for the treatment of early‐stage Alzheimer's disease have significantly shifted the clinical landscape. However, current use recommendations preclude the administration of these new drugs to persons who have Down syndrome.
Clíona Farrell +5 more
wiley +1 more source
, 2021 The kinase DYRK1A (dual-specificity tyrosine-regulated kinase 1A) is a dosage-sensitive gene, since both haploinsufficiency and overexpression when in trisomy lead to pathological phenotypes in humans.
Cort, Rianne Angelica, 1991-
core
The proviral role of DYRK1A is kinase independent.
, 2023 (A) DYRK1A protein domains and engineered point mutations. Nuclear localization mutants were generated by deletion of the bipartite nuclear localization motif and addition of a C-terminal nuclear export signal.
Scott B. Biering (7165010) +20 more
core +1 more source