Results 51 to 60 of about 6,457 (202)
Scientific Reports, 2022 AbstractAlzheimer’s disease (AD) involves pathological processing ofamyloid precursor protein(APP) into amyloid-β andmicrotubule associated protein Tau(MAPT)into hyperphosphorylated Tau tangles leading to neurodegeneration. Only 5% of AD cases are familial making it difficult to predict who will develop the disease thereby hindering our ability to ...
Bangfu Zhu +6 more
openaire +3 more sources
Disease Models & Mechanisms, 2018 Growing evidence supports the implication of DYRK1A in the development of cognitive deficits seen in Down syndrome (DS) and Alzheimer's disease (AD).
Thu Lan Nguyen +14 more
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Neurobiology of DiseaseAberrant neurodevelopment in Down syndrome (DS)—caused by triplication of human chromosome 21—is commonly attributed to gene dosage imbalance, linking overexpression of trisomic genes with disrupted developmental processes, with DYRK1A particularly ...
Laura E. Hawley +5 more
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DYRK1A interacts with the tuberous sclerosis complex and promotes mTORC1 activity
eLifeDYRK1A, a ubiquitously expressed kinase, is linked to the dominant intellectual developmental disorder, microcephaly, and Down syndrome in humans. It regulates numerous cellular processes such as cell cycle, vesicle trafficking, and microtubule assembly.
Pinhua Wang +17 more
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Mathematical model to study the nonlinear influence of Dyrk1A in actin polymerization
Frontiers in Systems Neuroscience, 2015 Dyrk1A is a member of the dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family. It is believed that Dyrk1A plays a significant role in signaling pathways regulating cell proliferation and may be involved in neuron development.
German Agustin Patterson
doaj +1 more source
Epilepsia Open, EarlyView.Abstract Objectives The objectives of this study were to develop a real‐world‐data (RWD) database for patients with epilepsy to provide further real‐world‐evidence (RWE) for monogenic genetic epilepsies; to assess the usefulness of a diagnostic algorithm in epilepsy; and to examine protein 3D structures using in silico tools to predict variant ...
Haley Morris +4 more
wiley +1 more source
A New Vista of Opportunity in Diabetes Management: Natural Product‐Based β‐cell Preservation
Food Chemistry International, EarlyView.Preserving functional β‐cells via natural products offers promising strategy for diabetes treatment. ABSTRACT A defining characteristic of diabetes is β‐cell failure, in which β‐cells cannot modulate insulin secretion to compensate for escalating insulin resistance, pushing forward disease development.
Yi‐San Lee +4 more
wiley +1 more source
DYRK1A affected NFATc2 protein phosphorylation.
, 2017 A. DYRK1A inhibitor harmine (2ug/ml) decreased NFATc1 expression (the image was flipped horizontally from the original picture). B. Anti-pSer antibody was used to detect the serine phosphorylated NFATc1 and rabbit anti-FLAG antibody was used to detect ...
Yuankai Zhang (3779878) +6 more
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CHARACTERIZATION OF THE DYRK1A PROTEIN-PROTEIN INTERACTION NETWORK
, 2020 Human Dual specificity tyrosine (Y)-Regulated Kinase 1A (DYRK1A) is a protein kinase encoded by a dosage-dependent gene. An extra copy of DYRK1A contributes to Down syndrome (DS) pathogenesis while loss of one allele causes severe mental retardation and ...
Ananthapadmanabhan, Varsha
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Redox Biology, 2018 Hyperhomocysteinemia due to cystathionine beta synthase (CBS) deficiency is associated with diverse cognitive dysfunction. Considering the role of the serine/threonine kinase DYRK1A, not only in developmental defects with life-long structural and ...
Vanessa Baloula +5 more
doaj +1 more source