Wnt/β-catenin signaling stimulates the expression and synaptic clustering of the autism-associated Neuroligin 3 gene [PDF]
, 2018 Indexación: Scopus.Synaptic abnormalities have been described in individuals with autism spectrum disorders (ASD). The cell-adhesion molecule Neuroligin-3 (Nlgn3) has an essential role in the function and maturation of synapses and NLGN3 ASD-associated ...
Andrade, V.M. +9 more
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The Omnipresence of DYRK1A in Human Diseases
International Journal of Molecular Sciences, 2022 The increasing population will challenge healthcare, particularly because the worldwide population has never been older. Therapeutic solutions to age-related disease will be increasingly critical. Kinases are key regulators of human health and represent promising therapeutic targets for novel drug candidates.
Estelle Deboever +3 more
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Rescue of the abnormal skeletal phenotype in Ts65Dn Down syndrome mice using genetic and therapeutic modulation of trisomic Dyrk1a [PDF]
, 2015 Trisomy 21 causes skeletal alterations in individuals with Down syndrome (DS), but the causative trisomic gene and a therapeutic approach to rescue these abnormalities are unknown.
Abeysekera, Irushi +3 more
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Inhibition of DYRK1A disrupts neural lineage specificationin human pluripotent stem cells
eLife, 2017 Genetic analysis has revealed that the dual specificity protein kinase DYRK1A has multiple roles in the development of the central nervous system. Increased DYRK1A gene dosage, such as occurs in Down syndrome, is known to affect neural progenitor cell ...
Stephanie F Bellmaine +8 more
doaj +1 more source
Alzheimer’s & Dementia: Translational Research & Clinical Interventions, 2020 Introduction An effective therapy has not yet been developed for Alzheimer's disease (AD), in part because pathological changes occur years before clinical symptoms manifest.
Jean M. Delabar +9 more
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Structural analysis of pathogenic mutations in the DYRK1A gene in patients with developmental disorders. [PDF]
, 2017 Haploinsufficiency in DYRK1A is associated with a recognizable developmental syndrome, though the mechanism of action of pathogenic missense mutations is currently unclear.
Ajoy Sarkar +32 more
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Identification and analysis of a selective DYRK1A inhibitor
Biomedicine & Pharmacotherapy, 2022 The dysregulation of DYRK1A is implicated in many diseases such as cancer, diabetes, and neurodegenerative diseases. Alzheimer's disease is one of the most common neurodegenerative disease and has elevated interest in DYRK1A research. Overexpression of DYRK1A has been linked to the formation of tau aggregates.
Lin, Tony Eight +11 more
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DCAF7/WDR68 is required for normal levels of DYRK1A and DYRK1B.
PLoS ONE, 2018 Overexpression of the Dual-specificity Tyrosine Phosphorylation-Regulated Kinase 1A (DYRK1A) gene contributes to the retardation, craniofacial anomalies, cognitive impairment, and learning and memory deficits associated with Down Syndrome (DS).
Mina Yousefelahiyeh +5 more
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Insights from the protein interaction Universe of the multifunctional “Goldilocks” kinase DYRK1A
Frontiers in Cell and Developmental Biology, 2023 Human Dual specificity tyrosine (Y)-Regulated Kinase 1A (DYRK1A) is encoded by a dosage-dependent gene located in the Down syndrome critical region of human chromosome 21.
Varsha Ananthapadmanabhan +4 more
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DYRK1A and the Cell Cycle [PDF]
, 2020 The ability to halt the cell cycle is critical for cells to maintain tissue and organ size, to suppress tumors and abnormal growth, and exists as a helpful mechanism to pause the cell cycle for DNA repair.
Byers, Holly +1 more
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