Results 31 to 40 of about 6,457 (202)
Genotyping of a Dyrk1a conditional mutant mice
, 2019 DYRK1A is a protein kinase involved in multiple cellular functions through its interaction with different substrates, such as transcription factors, splicing machinery components, RNA polymerase II, chromatin regulators, Cyclin D, Caspase-9 or RNF169 ...
González Díaz, Adrián
core +2 more sources
The role of DYRK1A in neurodegenerative diseases [PDF]
The FEBS Journal, 2010 Recent studies indicate that the dual‐specificity tyrosine phosphorylation‐regulated kinase 1A (DYRK1A) gene, which is located on chromosome 21q22.2 and is overexpressed in Down syndrome (DS), may play a significant role in developmental brain defects and in early onset neurodegeneration, neuronal loss and dementia in DS. The identification of hundreds
Jerzy, Wegiel +2 more
openaire +2 more sources
The Omnipresence of DYRK1A in Human Diseases
International Journal of Molecular Sciences, 2022 The increasing population will challenge healthcare, particularly because the worldwide population has never been older. Therapeutic solutions to age-related disease will be increasingly critical. Kinases are key regulators of human health and represent promising therapeutic targets for novel drug candidates.
Estelle Deboever +3 more
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Activation, regulation, and inhibition of DYRK1A [PDF]
The FEBS Journal, 2010 Dual‐specificity tyrosine phosphorylation‐regulated kinase 1A (DYRK1A) is a protein kinase with diverse functions in neuronal development and adult brain physiology. Higher than normal levels of DYRK1A are associated with the pathology of neurodegenerative diseases and have been implicated in some neurobiological alterations of Down syndrome, such as ...
Walter, Becker, Wolfgang, Sippl
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Identification and analysis of a selective DYRK1A inhibitor
Biomedicine & Pharmacotherapy, 2022 The dysregulation of DYRK1A is implicated in many diseases such as cancer, diabetes, and neurodegenerative diseases. Alzheimer's disease is one of the most common neurodegenerative disease and has elevated interest in DYRK1A research. Overexpression of DYRK1A has been linked to the formation of tau aggregates.
Lin, Tony Eight +11 more
openaire +3 more sources
, 2021 Deregulation of dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) plays a significant role in developmental brain defects, early-onset neurodegeneration, neuronal cell loss, and dementia.
Jeremiah, Zartman +9 more
core +1 more source
PLoS Genetics, 2021 Perturbation of the excitation/inhibition (E/I) balance leads to neurodevelopmental diseases including to autism spectrum disorders, intellectual disability, and epilepsy.
Véronique Brault +14 more
doaj +1 more source
Inhibition of DYRK1A disrupts neural lineage specificationin human pluripotent stem cells
eLife, 2017 Genetic analysis has revealed that the dual specificity protein kinase DYRK1A has multiple roles in the development of the central nervous system. Increased DYRK1A gene dosage, such as occurs in Down syndrome, is known to affect neural progenitor cell ...
Stephanie F Bellmaine +8 more
doaj +1 more source
DYRK1A regulates expression of ACE2 and DPP4.
, 2023 (A) Immunoblot for ACE2 in WT Vero-E6 and DYRK1A KO cells. (B) mRNA abundance of ACE2 and DPP4 transcripts in WT Vero-E6 and DYRK1A KO clones assessed by qPCR. ΔΔCT values are calculated relative to actin and normalized to WT Vero-E6 values.
Scott B. Biering (7165010) +20 more
core +1 more source
DYRK1A and cognition: A lifelong relationship
Pharmacology & Therapeutics, 2019 The dosage of the serine threonine kinase DYRK1A is critical in the central nervous system (CNS) during development and aging. This review analyzes the functions of this kinase by considering its interacting partners and pathways. The role of DYRK1A in controlling the differentiation of prenatal newly formed neurons is presented separately from its ...
Arbones, Maria L. +4 more
openaire +4 more sources