Results 21 to 30 of about 9,925 (218)
DYRK1A phosphorylates MEF2D and decreases its transcriptional activity [PDF]
Journal of Cellular and Molecular Medicine, 2021 AbstractMyocyte enhancer factor 2D (MEF2D) is predominantly expressed in the nucleus and associated with cell growth, differentiation, survival and apoptosis. Previous studies verified that phosphorylation at different amino acids determined MEF2's transcriptional activity which was essential in regulating downstream target genes expression.
Pin Wang, Juan Zhao, Xiulian Sun
openaire +2 more sources
K63-linked ubiquitination of DYRK1A by TRAF2 alleviates Sprouty 2-mediated degradation of EGFR
Cell Death and Disease, 2021 Dual specificity tyrosine phosphorylation regulated kinase 1A, DYRK1A, functions in multiple cellular pathways, including signaling, endocytosis, synaptic transmission, and transcription.
Pengshan Zhang +9 more
doaj +1 more source
Activation, regulation, and inhibition of DYRK1A [PDF]
The FEBS Journal, 2010 Dual‐specificity tyrosine phosphorylation‐regulated kinase 1A (DYRK1A) is a protein kinase with diverse functions in neuronal development and adult brain physiology. Higher than normal levels of DYRK1A are associated with the pathology of neurodegenerative diseases and have been implicated in some neurobiological alterations of Down syndrome, such as ...
Walter, Becker, Wolfgang, Sippl
openaire +2 more sources
Molecules, 2020 The β-carboline alkaloid harmine is a potent DYRK1A inhibitor, but suffers from undesired potent inhibition of MAO-A, which strongly limits its application.
Anne Wurzlbauer +7 more
doaj +1 more source
A novel de novo heterozygous DYRK1A mutation causes complete loss of DYRK1A function and developmental delay [PDF]
Scientific Reports, 2020 AbstractDual-specificity tyrosine phosphorylation-regulated kinase 1 A (DYRK1A) is essential for human development, and DYRK1A haploinsufficiency is associated with a recognizable developmental syndrome and variable clinical features. Here, we present a patient with DYRK1A haploinsufficiency syndrome, including facial dysmorphism, delayed motor ...
Lee, Kyu-Sun +9 more
openaire +2 more sources
PLoS Genetics, 2021 Perturbation of the excitation/inhibition (E/I) balance leads to neurodevelopmental diseases including to autism spectrum disorders, intellectual disability, and epilepsy.
Véronique Brault +14 more
doaj +1 more source
Regulation of Cardiomyocyte Proliferation by microRNAs and Small Molecules [PDF]
, 2018 Understanding the molecular mechanisms regulating cardiac cell proliferation during the embryonic, fetal and adult life holds a paramount importance in view of developing innovative strategies aimed at inducing myocardial regeneration after cardiac ...
Torrini, Consuelo
core +1 more source
The role of DYRK1A in neurodegenerative diseases [PDF]
The FEBS Journal, 2010 Recent studies indicate that the dual‐specificity tyrosine phosphorylation‐regulated kinase 1A (DYRK1A) gene, which is located on chromosome 21q22.2 and is overexpressed in Down syndrome (DS), may play a significant role in developmental brain defects and in early onset neurodegeneration, neuronal loss and dementia in DS. The identification of hundreds
Jerzy, Wegiel +2 more
openaire +2 more sources
Low Expression of DYRK2 (Dual Specificity Tyrosine Phosphorylation Regulated Kinase 2) Correlates with Poor Prognosis in Colorectal Cancer. [PDF]
, 2016 Dual-specificity tyrosine-phosphorylation-regulated kinase 2 (DYRK2) is a member of dual-specificity kinase family, which could phosphorylate both Ser/Thr and Tyr substrates. The role of DYRK2 in human cancer remains controversial.
Chu, Zhonghua +7 more
core +2 more sources
Intranasal rapamycin ameliorates Alzheimer-like cognitive decline in a mouse model of Down syndrome [PDF]
, 2018 Background: Down syndrome (DS) individuals, by the age of 40s, are at increased risk to develop Alzheimer-like dementia, with deposition in brain of senile plaques and neurofibrillary tangles.
Arena, Andrea +9 more
core +3 more sources