Increased plasma DYRK1A with aging may protect against neurodegenerative diseases [PDF]
Translational Psychiatry, 2023 Early markers are needed for more effective prevention of Alzheimer’s disease. We previously showed that individuals with Alzheimer’s disease have decreased plasma DYRK1A levels compared to controls.
Jean M. Delabar +11 more
doaj +2 more sources
Plasma DYRK1A as a novel risk factor for Alzheimer's disease [PDF]
Translational Psychiatry, 2014 International audienceTo determine whether apparent involvement of DYRK1A in Alzheimer's disease (AD) pathology makes it a candidate plasma biomarker for diagnosis, we developed a method to quantify plasma DYRK1A by immunoblot in transgenic mouse models ...
Potier, Mc +15 more
core +4 more sources
Exploring the role of DYRK1A in RNA polymerase III transcription : DYRK1A as a potential regulator of TFIIIC [PDF]
, 2019 The kinase DYRK1A (dual-specificity tyrosine-regulated kinase 1A) is a dosage-sensitive gene, since both haploinsufficiency and overexpression when in trisomy lead to pathological phenotypes in humans.
Cort, Rianne Angelica
core +3 more sources
DYRK1A Kinase Inhibitors with Emphasis on Cancer.
Mini-Reviews in Medicinal Chemistry, 2012 Various types of cancers (including gliomas, melanomas, and esophageal, pancreas and non-small-cell lung cancers) display intrinsic resistance to pro-apoptotic stimuli, such as conventional chemotherapy and radiotherapy, and/or the activation of a ...
Ionescu, Alexandra +6 more
core +5 more sources
DYRK1A in cancer: good or evil? : Defining properties of DYRK1A kinase as a novel tumor driver [PDF]
, 2019 DYRK (dual-specificity tyrosine-regulated kinases) is an evolutionary conserved family of protein kinases involved in the regulation of cellular processes, such as proliferation and survival, which play pivotal role in tumor development.
Boni, Jacopo
core +2 more sources
DYRK1A activates NFATC1 to increase glioblastoma migration [PDF]
Cancer Medicine, 2021 Glioblastoma (GBM) is the most aggressive glioma, and is prone to develop resistance to chemotherapy and radiotherapy; hence, patients with glioblastoma have a high recurrence rate and a low 1‐year survival rate.
Heng Liu +6 more
doaj +3 more sources
Alterations in the phenotype of neocortical pyramidal cells in the Dyrk1A+/− mouse
Neurobiology of Disease, 2005 The gene encoding the dual-specificity tyrosine-regulated kinase DYRK1A maps to the chromosomal segment HSA21q22.2, which lies within the Down syndrome critical region.
R. Benavides-Piccione +7 more
doaj +6 more sources
Impaired macroglial development and axonal conductivity contributes to the neuropathology of DYRK1A-related intellectual disability syndrome [PDF]
Scientific Reports, 2022 The correct development and activity of neurons and glial cells is necessary to establish proper brain connectivity. DYRK1A encodes a protein kinase involved in the neuropathology associated with Down syndrome that influences neurogenesis and the ...
Isabel Pijuan +5 more
doaj +2 more sources
DYRK1A and Parkinson’s disease, facts and hypotheses
Neurobiology of DiseaseThe dual-specificity, tyrosine phosphorylation-regulated kinase 1A (DYRK1A) is intensively studied because of its implication in numerous human diseases (Down syndrome, Alzheimer’s disease, type 2 diabetes, myocardial infarction, various cancers and ...
Laurent Meijer +3 more
doaj +2 more sources
NFATc1 phosphorylation by DYRK1A increases its protein stability.
PLoS ONE, 2017 NFATs are transcription factors involved in immune activation and tumor progression. Previous reports showed that DYRK1A suppressed NFATc2 transcriptional activity through phosphorylation.
Heng Liu +6 more
doaj +2 more sources