Results 41 to 50 of about 9,925 (218)
Toward the language oscillogenome [PDF]
, 2018 Language has been argued to arise, both ontogenetically and phylogenetically, from specific patterns of brain wiring. We argue that it can further be shown that core features of language processing emerge from particular phasal and cross-frequency ...
Benítez Burraco, Antonio +1 more
core +2 more sources
Safety and efficacy of cognitive training plus epigallocatechin-3-gallate in young adults with Down's syndrome (TESDAD): a double-blind, randomised, placebo-controlled, phase 2 trial [PDF]
, 2016 Background Early cognitive intervention is the only routine therapeutic approach used for amelioration of intellectual deficits in individuals with Down's syndrome, but its effects are limited.
Benejam, Bessy +14 more
core +2 more sources
Epigallocatechin-3-gallate (EGCG) consumption in the Ts65Dn model of Down syndrome fails to improve behavioral deficits and is detrimental to skeletal phenotypes [PDF]
, 2017 Down syndrome (DS) is caused by three copies of human chromosome 21 (Hsa21) and results in phenotypes including intellectual disability and skeletal deficits.
Abeysekera, Irushi +9 more
core +2 more sources
DYRK1A and cognition: A lifelong relationship
Pharmacology & Therapeutics, 2019 The dosage of the serine threonine kinase DYRK1A is critical in the central nervous system (CNS) during development and aging. This review analyzes the functions of this kinase by considering its interacting partners and pathways. The role of DYRK1A in controlling the differentiation of prenatal newly formed neurons is presented separately from its ...
Arbones, Maria L. +4 more
openaire +4 more sources
Cerebellar alterations in a model of Down syndrome: The role of the Dyrk1A gene
Neurobiology of Disease, 2018 Down syndrome (DS) is characterized by a marked reduction in the size of the brain and cerebellum. These changes play an important role in the motor alterations and cognitive disabilities observed in this condition.
Susana García-Cerro +8 more
doaj +1 more source
BMC Cell Biology, 2003 Background Previously we cloned the human MNB/DYRK1A gene from the "Down syndrome critical region" on chromosome 21. This gene encodes a dual specificity protein kinase that catalyzes its autophosphorylation on serine/threonine and tyrosine residues. But,
Hiraoka Yasushi +6 more
doaj +1 more source
Inhibition of DYRK1A can alleviate MPTP/MPP+-induced neuronal apoptosis and mitochondrial damage
Brain Research BulletinThe dual specificity tyrosine-regulated kinase 1a (DYRK1A) gene plays a crucial role in developing midbrain dopamine neurons. DYRK1A is closely related to Parkinson's disease(PD), and there are not many relevant studies.
Qian Cai +5 more
doaj +1 more source
Pharmacology of modulators of alternative splicing [PDF]
, 2016 More than 95% of genes in the human genome are alternatively spliced to form multiple transcripts, often encoding proteins with differing or opposing function.
Bates, DO +4 more
core +4 more sources
Scientific Reports, 2017 Dual-specificity tyrosine–phosphorylation regulated kinase 1A (DYRK1A) is localized in the Down syndrome critical region of chromosome 21. As a candidate gene responsible for learning defects associated with Down syndrome and Alzheimer’s disease (AD ...
Pin Wang +3 more
doaj +1 more source
Mining Public Domain Data to Develop Selective DYRK1A Inhibitors [PDF]
ACS Medicinal Chemistry Letters, 2020 Kinases represent one of the most intensively pursued groups of targets in modern-day drug discovery. Often it is desirable to achieve selective inhibition of the kinase of interest over the remaining ∼500 kinases in the human kinome. This is especially true when inhibitors are intended to be used to study the biology of the target of interest.
Henderson, SH +7 more
openaire +4 more sources