Results 41 to 50 of about 6,457 (202)
Alzheimer’s & Dementia: Translational Research & Clinical Interventions, 2020 Introduction An effective therapy has not yet been developed for Alzheimer's disease (AD), in part because pathological changes occur years before clinical symptoms manifest.
Jean M. Delabar +9 more
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DCAF7/WDR68 is required for normal levels of DYRK1A and DYRK1B.
PLoS ONE, 2018 Overexpression of the Dual-specificity Tyrosine Phosphorylation-Regulated Kinase 1A (DYRK1A) gene contributes to the retardation, craniofacial anomalies, cognitive impairment, and learning and memory deficits associated with Down Syndrome (DS).
Mina Yousefelahiyeh +5 more
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Insights from the protein interaction Universe of the multifunctional “Goldilocks” kinase DYRK1A
Frontiers in Cell and Developmental Biology, 2023 Human Dual specificity tyrosine (Y)-Regulated Kinase 1A (DYRK1A) is encoded by a dosage-dependent gene located in the Down syndrome critical region of human chromosome 21.
Varsha Ananthapadmanabhan +4 more
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MNB/DYRK1A as a multiple regulator of neuronal development [PDF]
The FEBS Journal, 2010 MNB/DYRK1A is a member of the dual‐specificity tyrosine phosphorylation‐regulated kinase (DYRK) family that has been strongly conserved across evolution. There are substantial data implicating MNB/DYRK1A in brain development and adult brain function, as well as in neurodegeneration and Down syndrome pathologies. Here we review our current understanding
Tejedor, Francisco J. +1 more
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Cerebellar alterations in a model of Down syndrome: The role of the Dyrk1A gene
Neurobiology of Disease, 2018 Down syndrome (DS) is characterized by a marked reduction in the size of the brain and cerebellum. These changes play an important role in the motor alterations and cognitive disabilities observed in this condition.
Susana García-Cerro +8 more
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FastGrow: on-the-fly growing and its application to DYRK1A
Journal of Computer-Aided Molecular Design, 2022 AbstractFragment-based drug design is an established routine approach in both experimental and computational spheres. Growing fragment hits into viable ligands has increasingly shifted into the spotlight. FastGrow is an application based on a shape search algorithm that addresses this challenge at high speeds of a few milliseconds per fragment.
Patrick Penner +7 more
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BMC Cell Biology, 2003 Background Previously we cloned the human MNB/DYRK1A gene from the "Down syndrome critical region" on chromosome 21. This gene encodes a dual specificity protein kinase that catalyzes its autophosphorylation on serine/threonine and tyrosine residues. But,
Hiraoka Yasushi +6 more
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Inhibition of DYRK1A can alleviate MPTP/MPP+-induced neuronal apoptosis and mitochondrial damage
Brain Research BulletinThe dual specificity tyrosine-regulated kinase 1a (DYRK1A) gene plays a crucial role in developing midbrain dopamine neurons. DYRK1A is closely related to Parkinson's disease(PD), and there are not many relevant studies.
Qian Cai +5 more
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DYRK1A Is a Novel Negative Regulator of Cardiomyocyte Hypertrophy [PDF]
Journal of Biological Chemistry, 2009 Activation of the phosphatase calcineurin and its downstream targets, transcription factors of the NFAT family, results in cardiomyocyte hypertrophy. Recently, it has been shown that the dual specificity tyrosine (Y) phosphorylation-regulated kinase 1A (DYRK1A) is able to antagonize calcineurin signaling by directly phosphorylating NFATs.
Christian, Kuhn +6 more
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Scientific Reports, 2017 Dual-specificity tyrosine–phosphorylation regulated kinase 1A (DYRK1A) is localized in the Down syndrome critical region of chromosome 21. As a candidate gene responsible for learning defects associated with Down syndrome and Alzheimer’s disease (AD ...
Pin Wang +3 more
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