Results 1 to 10 of about 9,925 (218)

DYRK1A roles in human neural progenitors [PDF]

Frontiers in Neuroscience
IntroductionMutations in dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) represent one of the most prevalent monogenic causes of neurodevelopmental disorders (NDDs), often associated with intellectual developmental disorder and ...
Jeremie Courraud, Jeremie Courraud, Jeremie Courraud, Jeremie Courraud, Angélique Quartier, Angélique Quartier, Angélique Quartier, Angélique Quartier, Nathalie Drouot, Nathalie Drouot, Nathalie Drouot, Nathalie Drouot, Irene Zapata-Bodalo, Irene Zapata-Bodalo, Irene Zapata-Bodalo, Irene Zapata-Bodalo, Johan Gilet, Johan Gilet, Johan Gilet, Johan Gilet, Alexandra Benchoua, Jean-Louis Mandel, Jean-Louis Mandel, Jean-Louis Mandel, Jean-Louis Mandel, Amélie Piton, Amélie Piton, Amélie Piton, Amélie Piton, Amélie Piton, Amélie Piton   +30 more
doaj   +4 more sources

DYRK1A modulates fear memory formation via epigenetic modification [PDF]

Molecular Brain
Fear memory formation is crucial for survival, with the hippocampus playing a central role. This study investigates the behavioral and molecular aspects of fear memory formation, focusing on Dual-specificity tyrosine phosphorylation-regulated kinase 1 A (
Dae-Si Kang, Ja Wook Koo
doaj   +4 more sources

Genetic knockdown of DYRK1A attenuates cognitive impairment, Aβ pathology, tauopathy and neuroinflammatory responses in mouse models of AD [PDF]

Frontiers in Immunology
IntroductionDual specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) is associated with the pathoprogression of neurodevelopmental and neurodegenerative disorders.
Hyun-ju Lee, Hyun-ju Lee, Sora Kang, Sora Kang, Yoo Jin Lee, Seokjun Oh, Seokjun Oh, Bitna Joo, Bitna Joo, Jeong-Woo Hwang, Jeong-Woo Hwang, Jeongseop Kim, Jeongseop Kim, Tae-Eun Kim, Tae-Mi Jung, Yu-Jin Kim, Ji-Yeong Jang, Ji-Yeong Jang, Ji-Yeong Jang, Jeong-Heon Song, Ja Wook Koo, Ja Wook Koo, Hyang-Sook Hoe, Hyang-Sook Hoe, Hyang-Sook Hoe   +24 more
doaj   +2 more sources

DYRK1A in the physiology and pathology of the neuron-astrocyte axis [PDF]

Frontiers in Neuroscience
Dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) is a dosage-sensitive kinase with critical roles in the neuron-astrocyte axis. During brain development, DYRK1A ensures the proper number of differentiated neurons and astrocytes.
Pablo Cisternas, Pablo Cisternas, Jiyoon Kim, Brandon Ashfeld, Jeremiah Zartman, Jeremiah Zartman   +5 more
doaj   +2 more sources

Excitation/inhibition balance and learning are modified by Dyrk1a gene dosage

Neurobiology of Disease, 2014
Cognitive deficits in Down syndrome (DS) have been linked to increased synaptic inhibition, leading to an imbalance of excitation/inhibition (E/I). Various mouse models and studies from human brains have implicated an HSA21 gene, the serine/threonine ...
Benoit Souchet, Faycal Guedj, Ignasi Sahún   +2 more
exaly   +3 more sources

Clinical and molecular overlap between nucleotide excision repair (NER) disorders and DYRK1A haploinsufficiency syndrome [PDF]

Frontiers in Neuroscience
Nucleotide excision repair (NER) disorders are genetic conditions caused by defects in the pathway responsible for repairing DNA lesions due to UV radiation. These defects lead to a variety of heterogeneous disorders, including Cockayne syndrome (CS) and
Nicolas Le May, Jérémie Courraud, Imène Boujelbène, Imène Boujelbène, Cathy Obringer, Tomoo Ogi, Alan R. Lehmann, Fanny Laffargue, Daphné Lehalle, Seiji Mizuno, Shehla Mohammed, Clothilde Ormières, Marjolaine Willems, Vincent Laugel, Vincent Laugel, Nadège Calmels, Nadège Calmels   +16 more
doaj   +2 more sources

Identification of FAM53C as a cytosolic-anchoring inhibitory binding protein of the kinase DYRK1A

Life Science Alliance, 2023
A previously uncharacterized protein, FAM53C, is identified as a binding partner for the kinase DYRK1A involved in numerous neurodevelopmental disorders, such as Down syndrome and autism spectrum disorder.
Yoshihiko Miyata, Eisuke Nishida
doaj   +1 more source

Optimization and validation of a DYRK1A TR-FRET assay for high-throughput screening

MethodsX, 2021
Due to its role in brain development, the DYRK1A kinase (dual-specificity tyrosine phosphorylation-regulated kinase 1a) has been proposed as a drug target for Down syndrome, and diseases associated with neurodegeneration including Alzheimer's and ...
Michael Tarpley, Thomas B. Caligan, Rob U. Onyenwoke, Kevin P. Williams   +3 more
doaj   +1 more source

Global phosphoproteomics reveals DYRK1A regulates CDK1 activity in glioblastoma cells

Cell Death Discovery, 2021
Both tumour suppressive and oncogenic functions have been reported for dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A). Herein, we performed a detailed investigation to delineate the role of DYRK1A in glioblastoma.
Ariadna Recasens, Sean J. Humphrey, Michael Ellis, Monira Hoque, Ramzi H. Abbassi, Brianna Chen, Mitchell Longworth, Elise J. Needham, David E. James, Terrance G. Johns, Bryan W. Day, Michael Kassiou, Pengyi Yang, Lenka Munoz   +13 more
doaj   +1 more source

Genetic landscape of autism spectrum disorder in Vietnamese children [PDF]

, 2020
Autism spectrum disorder (ASD) is a complex disorder with an unclear aetiology and an estimated global prevalence of 1%. However, studies of ASD in the Vietnamese population are limited.
Bui, HTP, Dao, LTM, Do, DH, Ha, LT, Le, HTT, Le, VS, Ly, HTT, Mukhopadhyay, A, Nguyen, HT, Nguyen, HT, Nguyen, LT, Tran, KT, Vu, DM   +12 more
core   +2 more sources