DYRK1A in the physiology and pathology of the neuron-astrocyte axis [PDF]
Frontiers in NeuroscienceDual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) is a dosage-sensitive kinase with critical roles in the neuron-astrocyte axis. During brain development, DYRK1A ensures the proper number of differentiated neurons and astrocytes.
Pablo Cisternas +5 more
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Orchestrating mitochondrial protein import: The emerging role of DYRK1A in health and disease. [PDF]
Protein SciAbstract The translocase of the outer mitochondrial membrane (TOM complex) serves as the central entry gate for more than 1000 nuclear‐encoded precursor proteins imported into the organelle. Recently, the human import receptor TOM70 has been identified as a substrate of the serine/threonine kinase DYRK1A.
Shankar S, Meisinger C.
europepmc +2 more sources
Genetic knockdown of DYRK1A attenuates cognitive impairment, Aβ pathology, tauopathy and neuroinflammatory responses in mouse models of AD [PDF]
Frontiers in ImmunologyIntroductionDual specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) is associated with the pathoprogression of neurodevelopmental and neurodegenerative disorders.
Hyun-ju Lee +24 more
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Excitation/inhibition balance and learning are modified by Dyrk1a gene dosage
Neurobiology of Disease, 2014 Cognitive deficits in Down syndrome (DS) have been linked to increased synaptic inhibition, leading to an imbalance of excitation/inhibition (E/I). Various mouse models and studies from human brains have implicated an HSA21 gene, the serine/threonine ...
Ignasi Sahun +2 more
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Identification of FAM53C as a cytosolic-anchoring inhibitory binding protein of the kinase DYRK1A
Life Science Alliance, 2023 A previously uncharacterized protein, FAM53C, is identified as a binding partner for the kinase DYRK1A involved in numerous neurodevelopmental disorders, such as Down syndrome and autism spectrum disorder.
Yoshihiko Miyata, Eisuke Nishida
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Optimization and validation of a DYRK1A TR-FRET assay for high-throughput screening
MethodsX, 2021 Due to its role in brain development, the DYRK1A kinase (dual-specificity tyrosine phosphorylation-regulated kinase 1a) has been proposed as a drug target for Down syndrome, and diseases associated with neurodegeneration including Alzheimer's and ...
Michael Tarpley +3 more
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Global phosphoproteomics reveals DYRK1A regulates CDK1 activity in glioblastoma cells
Cell Death Discovery, 2021 Both tumour suppressive and oncogenic functions have been reported for dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A). Herein, we performed a detailed investigation to delineate the role of DYRK1A in glioblastoma.
Ariadna Recasens +13 more
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Kaohsiung Journal of Medical Sciences, 2023 This study aimed to explore the role and mechanism of DYRK1a regulating ferroptosis of cardiomyocytes during myocardial ischemia–reperfusion injury (MIRI).
Jing Wang +5 more
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K63-linked ubiquitination of DYRK1A by TRAF2 alleviates Sprouty 2-mediated degradation of EGFR
Cell Death and Disease, 2021 Dual specificity tyrosine phosphorylation regulated kinase 1A, DYRK1A, functions in multiple cellular pathways, including signaling, endocytosis, synaptic transmission, and transcription.
Pengshan Zhang +9 more
doaj +1 more source
Molecules, 2020 The β-carboline alkaloid harmine is a potent DYRK1A inhibitor, but suffers from undesired potent inhibition of MAO-A, which strongly limits its application.
Anne Wurzlbauer +7 more
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