Results 101 to 110 of about 9,925 (218)
Harmine Derivatives as Anticancer Agents Endowed With Potent and Selective Antileukemia Activity: Synthesis, Biological Evaluation, Proapoptotic and Genotoxic Activity
Archiv der Pharmazie, Volume 359, Issue 2, February 2026.We identified a novel N9‐substituted harmine analog, compound 6, that selectively suppresses leukemic cell growth, triggers DNA damage, and activates apoptosis while sparing healthy fibroblasts. This discovery highlights N9‐modified β‐carbolines as a powerful new class of selective antileukemic agents, bridging natural product chemistry with next ...Abdul Aziz Timbilla, Filip Pidany, Eliska Kohelova, Jana Kroustkova, Karel Kralovec, Jan Rataj, Martina Ceckova, Negar Maafi, Víctor Lopez, Cristina Moliner Langa, Stefan Kosturko, Jaroslav Jenco, Darina Muthna, Darja Koutova, Martina Rezacova, Lucie Cahlikova, Jakub Chlebek, Radim Havelek +17 morewiley +1 more sourceConstitutive Dyrk1A is abnormally expressed in Alzheimer disease, Down syndrome, Pick disease, and related transgenic models
Neurobiology of Disease, 2005 DYRK1A, dual-specificity tyrosine-regulated kinase 1A, maps to human chromosome 21 within the Down syndrome (DS) critical region. Dyrk1 phosphorylates the human microtubule-associated protein tau at Thr212 in vitro, a residue that is phosphorylated in ...Isidro Ferrer, Marta Barrachina, Berta Puig, M. Martínez de Lagrán, Eulalia Martí, Jesús Avila, Mara Dierssen +6 moredoaj +1 more sourceUsing C. elegans to decipher the cellular and molecular mechanisms underlying neurodevelopmental disorders [PDF]
, 2013 Prova tipográfica (uncorrected proof)Neurodevelopmental disorders such as epilepsy, intellectual disability (ID), and autism spectrum disorders (ASDs) occur in over 2 % of the population, as the result of genetic mutations, environmental factors, or ...A Briancon-Marjollet, A Chauhan, A Gloria-Soria, A Kuhara, A Mohri, A Okazaki, A Rosenthal, A Teixeira-Castro, A Thorsell, A Ward, AA Beg, AB Vashlishan, AC Hart, AG Fraser, AG Wright, AJ Rodrigues, AJ Rodrigues, AK Fu, AM Bender, AM Koivisto, AM Leifer, Ana João Rodrigues, AY Hung, B Calamini, B Hsiao, BA Bamber, BA Bamber, BC Kraemer, BC Kraemer, BC Kraemer, C Aydin, C Caceres Ide, C Cardoso, C Fatouros, C Jee, C Joly, C Lenski, C Rogers, C Sala, C Sala, C Stigloher, Carlos Bessa, CD Beck, CD Link, CH Rankin, CI Bargmann, CJ Epstein, CJ Locke, CJ Locke, CL Gatto, CR Guthrie, D Castermans, D Kleine-Kohlbrecher, D Lee, D Lee, D Levitan, D Sato, D Sieburth, D Weinshenker, DC Soares, DD Shaye, DF Cully, DH Hall, DJ Clancy, DJ Picketts, DL Chase, DT Pilz, E Fransen, E Kabashi, E Yeh, EZ Macosko, F Calahorro, F Calahorro, F Guedj, F Laumonnier, F Laumonnier, F Piano, F Simmer, F Simmer, F Zhang, FF Hamdan, FS Alkuraya, G Esposito, G Jansen, G Kerjan, G Voer de, GE Morrison, GG Farias, GP Demyanenko, GP Demyanenko, GP Demyanenko, H Asada, H Khosravani, H Lubs, H Saitsu, H Sasakura, H Zhao, HG Kim, HK Shamloula, I Helbig, I Mori, I Topalidou, J Apfeld, J Bond, J Falk, J Higgins, J Ortiz-Abalia, J Park, J Pevsner, J Qiu, J Yan, JA Dent, JA Kearney, JA Zallen, JB Ackman, JB Palcoux, JE Chubb, JE Lee, JE Mellem, JE Richmond, JF Liewald, JG Culotti, JG White, JI Lee, JJ Fuentes, JK Rose, JK Rose, JL Noebels, JL Noebels, JM Bellanger, JM Kramer, JM McEwen, JM Wheeler, JN Pulvers, JN Stirman, JR Arron, JS Dittman, JW Hunter, JY Wen, K Evason, K Evason, K Gengyo-Ando, K Kitamura, K Nehrke, K Poirier, K Rijkers, K Schuske, K Sossey-Alaoui, K Volders, KD Kernohan, KD Kimura, L Avery, L Haklai-Topper, L Medrihan, L Timmons, LA Brown, LM Dibbens, M Artal-Sanz, M Ballivet, M Bono de, M Chalfie, M Chalfie, M Dierssen, M Galli, M Guipponi, M Hammarlund, M Holzenberger, M Jensen, M Jouet, M Katidou, M Marvanova, M Rachidi, M Rachidi, M Tatar, M Tucker, M Verhage, M Voet van der, M Zhen, MB Goodman, MD Bono, MH Willemsen, MK Monteilh-Zoller, ML Nonet, ML Nonet, MM Barr, MM Francis, MM Francis, MN Wu, N Souza de, N Tavernarakis, N Wittenburg, NP Mongan, O Hobert, OK Steinlein, OK Steinlein, P Cossette, P Gonczy, P Igarashi, P Strippoli, P Stromme, PA Filipek, Patrícia Maciel, PJ Brockie, PJ Brockie, PW Faber, Q Liu, Q Wu, R Baran, R Baumeister, R Gibbons, R Kerr, R Nass, R O'Hagan, R Pandey, R Pocock, RA Kumar, RB Forthun, RD Groth, RJ Gibbons, RK Choy, RK Choy, RK Hukema, RM Weimer, RY Lee, S Cao, S Hamamichi, S Harbinder, S Hirose, S Jamain, S Libert, S Lin, S Naisbitt, S Ramanathan, S Saeki, S Steidl, S Vartiainen, S-Y Chen, SB Pierce, SE Hong, SF Kash, SH Chung, SH Gerber, SH Satyal, SJ Kulkarni, SL Smart, SN Williams, SR Lockery, SR Wicks, SR Wicks, T Chae, T Karl, T Marui, T Melkman, T Miyasaka, T Nguyen, T Oeda, TC Kwok, TE Thorgeirsson, TG Smart, TH Lindsay, TM DeLorey, TM Stawicki, TW Abrams, V Castellani, V Schuler, VM Kalscheuer, W Li, W Li, WB Dobyns, WB Raich, WC Oh, WT Nickell, X Wang, X Wang, X Wang, X Zhang, XH Jaglin, Y Jin, Y Lu, Y Nishida, Y Sambongi, Y Zhang, YB Qi +282 morecore +1 more sourceBrain volume trajectories in Down syndrome and autosomal dominant Alzheimer's disease
Alzheimer's &Dementia, Volume 22, Issue 1, January 2026.Abstract INTRODUCTION
It is unknown if neurodegeneration trajectories differ between Down syndrome (DS) and autosomal dominant Alzheimer's disease (ADAD), both of which are genetic forms of Alzheimer's disease (AD). METHODS
We compared brain volumes in DS, ADAD, and unaffected family members serving as controls.James T. Kennedy, Julie K. Wisch, Anna H. Boerwinkle, Peter R. Millar, Nicole S. McKay, Adam M. Brickman, Jasmeer P. Chhatwal, Patricio Chrem Mendez, Bradley T. Christian, Anne Cohen, Carlos Cruchaga, Alisha Daniels, Shaney Flores, Benjamin L. Handen, Sigan L. Hartley, Elizabeth Head, Laura Ibanez, Sharon J. Krisnsky‐McHale, Christian la Fougere, Florence Lai, Charles M. Laymon, Joseph H. Lee, Jae‐Hong Lee, Johannes Levin, Jorge Llibre‐Guerra, David F. Aguillon, Ira T. Lott, Mark Mapstone, Eric McDade, John Morris, Sid E. O'Bryant, Julie C. Price, Michael S. Rafii, Jee Hoon Roh, H. Diana Rosas, Nicole Schupf, Charlene Supnet‐Bell, Chengjie Xiong, Shahid Zaman, Tammie L. S. Benzinger, Brian A. Gordon, Beau M. Ances, the Alzheimer's Brain Consortium – Down Syndrome, and the Dominantly Inherited Alzheimer's Network +43 morewiley +1 more sourceSynthesis and biological activities of aminopyrimidyl-indoles structurally related to meridianins [PDF]
, 2009 International audienceThe synthesis of new meridianin derivatives substituted at the C-5 position of the 2-aminopyrimidine ring by various aryl groups and substituted or not by a methyl group on the indole nitrogen is described.Akué-Gédu, Rufine, Anizon, Fabrice, Debiton, Eric, Ferandin, Yoan, Meijer, Laurent, Moreau, Pascale, Prudhomme, Michelle +6 morecore +1 more sourceMolecular genetics of intellectual disability [PDF]
, 2012 The goal of this chapter is to review the current knowledge of the genetic causes of
intellectual disability, focusing on alterations at the chromosomal and single gene level, with particular mention to the new technological developments, including ...Bessa, C., Lopes, Fátima, Maciel, P.core +2 more sourcesChemical Constituents and Biological Activities of Oxandra (Annonaceae): A Review
Chemistry &Biodiversity, Volume 23, Issue 1, January 2026.ABSTRACT
Oxandra (Annonaceae) comprises 29 species distributed across South and Central America. Despite this diversity, the genus remains under‐investigated. This study presents the first comprehensive review of the chemical composition and biological activities of Oxandra species, utilizing databases such as SciFinder, ScienceDirect, PubMed, and ...Rayssa Cota Lopes, Francisco Paiva Machado, Mateus de Freitas Brito, Thalisson Amorim de Souza, Lucas Silva Abreu +4 morewiley +1 more sourcePan‐cancer multi‐omics reveals DCAF7 as an immune‐modulating prognostic driver and Wnt/β‐catenin activator in hepatocellular carcinoma
Clinical and Translational Medicine, Volume 16, Issue 1, January 2026.DCAF7 is up‐regulated in various tumours and correlates with poor prognosis, particularly in LIHC.
High DCAF7 expression is linked to CD4+ T cell infiltration, up‐regulation of immune checkpoint genes and increased tumour mutational burden, suggesting a role in tumour immune escape.Ruina Luan, Hanbin Lin, Xin Zhao, Jianpeng Li, Maohe Chen, Shiping Luo, Xinjian Lin +6 morewiley +1 more sourceEGCG from different sources: differential stability and effects on treating bone phenotypes related to Down syndrome [PDF]
, 2014 poster abstractDown Syndrome (DS) is a genetic disorder caused by trisomy of human chromosome 21 (Hsa21). DS phenotypes include cognitive impairment, craniofacial abnormalities, low muscle tone, and skeletal deficiencies.Abeysekera, Irushi S., Blazek, Joshua D., Roper, Randall J., Thomas, Jared R. +3 morecore
