Results 101 to 110 of about 6,457 (202)
Journal of Enzyme Inhibition and Medicinal ChemistryDual-specificity tyrosine-regulated kinase 1 A (DYRK1A) is crucial in neurogenesis, synaptogenesis, and neuronal functions. Its dysregulation is linked to neurodegenerative disorders like Down syndrome and Alzheimer’s disease. Although the development of
Huang-Ju Tu +10 more
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Green tea polyphenols rescue of brain defects induced by overexpression of DYRK1A.
PLoS ONE, 2009 Individuals with partial HSA21 trisomies and mice with partial MMU16 trisomies containing an extra copy of the DYRK1A gene present various alterations in brain morphogenesis.
Fayçal Guedj +10 more
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Proteasome inhibitors do not increase DYRK1A level.
, 2018 A) HeLa NT2 and Δwdr68-21 (Δ21) cells mock (-) or treated with 50μM LLNL for 6 hours. DYRK1A panel: Lanes 1 and 3, endogenous DYRK1A was readily detected in NT1 cells and unaffected by exposure to 50μM LLnL.
Estibaliz Alvarado (275856) +5 more
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Structural and Biochemical Studies of DYRK1A Kinase
, 2022 DYRK1A is a protein kinase and target for drug design. It was first discovered in neurological tissues and linked to neurological disease, particularly Down Syndrome and Alzheimer’s disease, where few treatment options are available.
Basantes Alvarez, Laura Emilia
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Anioonse fragmendi mõju proteiinkinaaside CK2 ja DYRK1A inhibiitorite afiinsusele [PDF]
, 2018 Käesolevas töös iseloomustatakse CK2 bisubstraatsete inhibiitorite seondumisvõimet proteiinkinaasile DYRK1A. Võrreldi 16 inhibiitorit, mis erinesid üksteisest proteiinkinaasi ATP-taskusse suunatud struktuurielemendi ja sellega seotud anioonse fragmendi ...
Issajev, Artjom
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RNF169 and RNF168 novel substrates of DYRK1A : connecting DYRK1A to DNA-damage repair
Gene dosage alterations of the kinase DYRK1A are linked to disease in humans. To better understand DYRK1A activities an interactome analysis was performed.
Roewenstrunk, Julia Maria
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Zur Funktion der Kinase Dyrk1A im Gehirn der adulten Maus [PDF]
, 2003 The Drosophila gene minibrain codes for a protein kinase. Mutants with a reduced expression of minibrain are characterised by a strongly reduced brain size and learning and memory deficits.
Sitz, J., Sitz, Jan Hendrik
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Clinical and Experimental HypertensionPulmonary arterial hypertension (PAH) is characterized by progressive vascular remodeling caused by the excessive proliferation and survival of pulmonary artery smooth muscle cells (PASMCs).
Cong Lan +5 more
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Understanding the Multifaceted Role of Human Down Syndrome Kinase DYRK1A
, 2016 The dual-specificity tyrosine (Y) phosphorylation-regulated kinase DYRK1A, also known as Down syndrome (DS) kinase, is a dosage-dependent signaling kinase that was originally shown to be highly expressed in DS patients as a consequence of trisomy 21 ...
Smulders-srinivasan, Tora; id_orcid +7 more
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Identification of DYRK1A-targeted motifs in NFATc1 protein.
, 2017 A. Diagram showed NFATs sequence alignment. Sequences of NFATc1 (NP_765978), NFATc2 (NP_775114), NFATc3 (NP_775118), and NFATc4 (NP_001129494) were aligned using ClustalW2 software. Conserved regions among NFATs are underlined.
Yuankai Zhang (3779878) +6 more
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