Results 171 to 180 of about 199,474 (298)
Effect of Gut Dysbiosis on Onset of GI Cancers
Dysbiosis in the gut microbiota plays a significant role in GI cancer development by influencing immune function and disrupting metabolic functions.
Mundla Srilatha +2 more
core +1 more source
Annals of Gastroenterological Surgery, EarlyView.ABSTRACT Small intestinal bacterial overgrowth (SIBO) has recently gained increasing attention as a potential cause of postoperative gastrointestinal symptoms following gastrointestinal cancer surgery. Surgical procedures can disrupt normal gastrointestinal physiology through anatomical reconstruction, impaired motility, reduced gastric acid secretion,
Toru Aoyama +2 more
wiley +1 more source
International Forum of Allergy &Rhinology, EarlyView.ABSTRACT Background Patients with chronic rhinosinusitis with nasal polyps (CRSwNP) exhibit heterogeneous responses to oral glucocorticoids (GCs), but the biological basis of this variability remains unclear. Objective To identify gut microbiome‒plasma metabolomic signatures associated with GC responsiveness in CRSwNP patients and to compare their ...
Ying‐Ying Zhang +7 more
wiley +1 more source
Animal Models and Experimental Medicine, EarlyView.We established ABCA1‐knockout Syrian golden hamsters as a novel and physiologically relevant model for colitis research. When challenged with a high‐fat diet, ABCA1‐deficient hamsters developed exacerbated colonic inflammation and impaired mucosal barrier integrity, driven by intracellular cholesterol accumulation.
Chang Liu +10 more
wiley +1 more source
Gut dysbiosis in mania: A viable therapeutic target?
, 2016 Gut dysbiosis in mania: A viable therapeutic ...
Michael Berk (13060851) +1 more
core
Animal Models and Experimental Medicine, EarlyView.Meticulous calculation of zebrafish‐equivalent therapeutic valproic acid (VPA) dosage maximized the translational value of the data. Hyposerotonergic tone underpinned an anxiety‐like outcome as a core symptom of autism spectrum disorder (ASD). Compartment‐specific dopaminergic and serotonergic dysregulation in the brain versus gut provided mechanistic ...
Lesha Pretorius +3 more
wiley +1 more source
Animal Models and Experimental Medicine, EarlyView.Anemia of inflammation is a highly prevalent secondary anemia complicating chronic inflammatory diseases. Current animal models are categorized into sterile inflammation, disease‐specific, and genetically engineered models, with comparative analysis of their modeling principles, characteristic phenotypes, and translational advantages to elucidate core ...
Jiayi Cheng +4 more
wiley +1 more source
npj Biofilms and MicrobiomesPathogenesis of periodontitis is marked by microbiota dysbiosis and disrupted host responses. Porphyromonas gingivalis is a keystone pathogen of periodontitis which expresses various crucial virulence factors.
Jing Ding +8 more
doaj +1 more source
The causes of intestinal dysbiosis: a review
, 2010 Alterations in the bowel flora and its activities are now believed to be contributing factors to many chronic and degenerative diseases. Irritable bowel syndrome, inflammatory bowel disease, rheumatoid arthritis, and ankylosing spondylitis have all been ...
Myers, Stephen P, Hawrelak, Jason A
core
Animal Research and One Health, EarlyView.This study aimed to investigate the potential of a mannan‐rich fraction (MRF) as a dietary intervention to alleviate weaning stress in piglets. Our results revealed that MRF could alleviate weaning stress by modulating the gut microbiota and the TLR5/NF‐κB signaling pathway, offering a novel and sustainable alternative to antibiotic use in swine ...
Yutong Lu +8 more
wiley +1 more source