Results 31 to 40 of about 199,474 (298)

Emerging role of gut microbiota dysbiosis in neuroinflammation and neurodegeneration

Frontiers in Neurology, 2023
Alzheimer's disease (AD), is a chronic age-related progressive neurodegenerative disorder, characterized by neuroinflammation and extracellular aggregation of Aβ peptide. Alzheimer's affects every 1 in 14 individuals aged 65 years and above.
Riddhi Solanki, A. Karande, Prathibha Ranganathan   +2 more
semanticscholar   +1 more source

Antibiotic-Therapy-Induced Gut Dysbiosis Affecting Gut Microbiota—Brain Axis and Cognition: Restoration by Intake of Probiotics and Synbiotics

International Journal of Molecular Sciences, 2023
Antibiotic therapy through short-term or repeated long-term prescriptions can have several damaging effects on the normal microbiota of the gastrointestinal tract.
Divakar Dahiya, P. Nigam
semanticscholar   +1 more source

Dysbiosis: The first hit for digestive system cancer

Frontiers in Physiology, 2022
Gastrointestinal cancer may be associated with dysbiosis, which is characterized by an alteration of the gut microbiota. Understanding the role of gut microbiota in the development of gastrointestinal cancer is useful for cancer prevention and gut ...
Si Mei, Si Mei, Zhe Deng, Zhe Deng, Yating Chen, Yating Chen, Dimin Ning, Dimin Ning, Yinmei Guo, Xingxing Fan, Ruoyu Wang, Ruoyu Wang, Yuelin Meng, Yuelin Meng, Qing Zhou, Xuefei Tian, Xuefei Tian   +16 more
doaj   +1 more source

Gut dysbiosis: Ecological causes and causative effects on human disease

Proceedings of the National Academy of Sciences of the United States of America, 2023
Significance Few recent advances in human medicine have been as influential as the finding that an imbalance (dysbiosis) of our resident microbial communities in the colon is linked to many chronic human illnesses.
Sebastian E. Winter, A. Bäumler
semanticscholar   +1 more source

Dysbiosis of a microbiota–immune metasystem in critical illness is associated with nosocomial infections

Nature Medicine, 2023
Dysbiosis of the gut microbiome in critically ill patients, coupled with impaired innate immune responses, may lower the barrier to acquiring infectious pathogens in the hospital setting.
J. Schlechte, A. Zucoloto, Ian-Ling Yu, C. Doig, M. Dunbar, K. McCoy, B. McDonald   +6 more
semanticscholar   +1 more source

Gut microbiome dysbiosis in Alzheimer’s disease and mild cognitive impairment: A systematic review and meta-analysis

PLoS ONE, 2023
Background Alzheimer’s disease (AD) is a neurodegenerative disorder that causes gradual memory loss. AD and its prodromal stage of mild cognitive impairment (MCI) are marked by significant gut microbiome perturbations, also known as gut dysbiosis ...
Sherlyn Jemimah, Chahd Chabib, L. Hadjileontiadis, A. Alshehhi   +3 more
semanticscholar   +1 more source

Genetic dysbiosis: the role of microbial insults in chronic inflammatory diseases [PDF]

, 2014
Thousands of bacterial phylotypes colonise the human body and the host response to this bacterial challenge greatly influences our state of health or disease. The concept of infectogenomics highlights the importance of host genetic factors in determining
Syed Tariq Sadiq, Nibali, L, Luigi Nibali, Henderson, B, Sadiq, ST, Brian Henderson, Donos, N, Nikos Donos   +7 more
core   +2 more sources

Gut- and oral-dysbiosis differentially impact spinal- and bulbar-onset ALS, predicting ALS severity and potentially determining the location of disease onset

BMC Neurology, 2022
Background Prior studies on the role of gut-microbiome in Amyotrophic Lateral Sclerosis (ALS) pathogenesis have yielded conflicting results. We hypothesized that gut- and oral-microbiome may differentially impact two clinically-distinct ALS subtypes ...
Harper S. Kim, John Son, Donghwan Lee, Joy Tsai, Danny Wang, E. Sandra Chocron, Seongwoo Jeong, Pamela Kittrell, Charles F. Murchison, Richard E. Kennedy, Alejandro Tobon, Carlayne E. Jackson, Andrew M. Pickering   +12 more
doaj   +1 more source

Current understanding of antibiotic-associated dysbiosis and approaches for its management

Therapeutic Advances in Infectious Disease, 2023
Increased exposure to antibiotics during early childhood increases the risk of antibiotic-associated dysbiosis, which is associated with reduced diversity of gut microbial species and abundance of certain taxa, disruption of host immunity, and the ...
Dhanasekhar Kesavelu, P. Jog
semanticscholar   +1 more source

The Cytokine System's Status in Bacterial Dysbiosis and Bacterial Vaginosis [PDF]

, 2020
Interrelations of conditionally-pathogenic microflora and vaginal mucosa's APC are realized by forming of proinflammatory and regulatory cytokines which can provoke bacterial dysbiosis progression and bacterial vaginosis development.The aim of the study:
Oleksandr Hruzevskyi, Hruzevskyi, O. (Oleksandr), Hruzevskyi, Oleksandr   +2 more
core   +1 more source