Results 111 to 120 of about 349,122 (350)

Circulating TREM2 as a noninvasive diagnostic biomarker for NASH in patients with elevated liver stiffness

Hepatology, EarlyView., 2022
Abstract Background and Aims Reliable noninvasive biomarkers are an unmet clinical need for the diagnosis of NASH. This study investigates the diagnostic accuracy of the circulating triggering receptor expressed on myeloid cells 2 (plasma TREM2) as a biomarker for NASH in patients with NAFLD and elevated liver stiffness.
Vineesh Indira Chandran, Charlotte Wilhelmina Wernberg, Mette Munk Lauridsen, Maria Kløjgaard Skytthe, Sofie Marchsteiner Bendixen, Frederik Tibert Larsen, Camilla Dalby Hansen, Lea Ladegaard Grønkjær, Majken Storm Siersbæk, Tina Di Caterino, Sönke Detlefsen, Holger Jon Møller, Lars Grøntved, Kim Ravnskjaer, Søren Kragh Moestrup, Maja Sofie Thiele, Aleksander Krag, Jonas Heilskov Graversen   +17 more
wiley   +1 more source

Genetic Association Between Insulin Resistance And Total Cholesterol In Type 2 Diabetes Mellitus - A Preliminary Observation [PDF]

, 2005
We investigated the degree of genetic association between insulin resistance (IR) with type 2 diabetes mellitus (DM) and abnormalities in lipid metabolism in 42 patients.
Gunasekara Sudari Wijewickrama, Hettihewa Lukshmy Menik, Imendra Kotapola, Jayasinghe Sudheera Sammanthi, Palangasinghe Shalika, Weerarathna Thilak Priyantha   +5 more
core   +1 more source

Liver Stiffness Rises Early in MASLD and Drives Inflammation, Lipid Dysmetabolism, and Fibrosis via Piezo1–YAP Mechanotransduction

Advanced Science, EarlyView.
Progressive stiffening of the hepatic extracellular matrix and free fatty acid overload activate the mechanosensor Piezo1 in steatotic hepatocytes, inducing calcium influx and nuclear translocation of Yes‐associated protein. YAP‐dependent nuclear signaling further drives inflammatory and fibrotic gene programs, lipid metabolic reprogramming, and ...
Juan Ma, Ning Xie, Ziwei Wang, Xiru Liang, Yulong Han, Qiang Zhao, Ming Wang, Hongwei Lu, Wanyi Kou, William Alazawi, Jinhai Wang, Lu Li, Ning Liu, Na Liu, Haitao Shi, Feng Xu   +15 more
wiley   +1 more source

Apolipoprotein F is reduced in humans with steatosis and controls plasma triglyceride‐rich lipoprotein metabolism

Hepatology, EarlyView., 2022
Hepatic APOF transcript levels correlate inversely with plasma TG and hepatic steatosis in humans. ApoF expression in mice promotes VLDL‐TG production and lipoprotein remnant clearance in mice. Abstract Background NAFLD affects nearly 25% of the global population. Cardiovascular disease (CVD) is the most common cause of death among patients with NAFLD,
Audrey Deprince, Nathalie Hennuyer, Sander Kooijman, Amanda C. M. Pronk, Eric Baugé, Viktor Lienard, An Verrijken, Eveline Dirinck, Luisa Vonghia, Eloïse Woitrain, Niels J. Kloosterhuis, Eléonore Marez, Pauline Jacquemain, Justina C. Wolters, Fanny Lalloyer, Delphine Eberlé, Sandrine Quemener, Emmanuelle Vallez, Anne Tailleux, Mostafa Kouach, Jean‐Francois Goossens, Violeta Raverdy, Bruno Derudas, Jan Albert Kuivenhoven, Mikaël Croyal, Bart van de Sluis, Sven Francque, François Pattou, Patrick C. N. Rensen, Bart Staels, Joel T. Haas   +30 more
wiley   +1 more source

Prevalence and pattern of dyslipidemia in Nepalese individuals with type 2 diabetes

BMC Research Notes, 2017
Background Atherogenic dyslipidemia is an important modifiable risk factor for cardiovascular disease among patients of type 2 diabetes mellitus.
Daya Ram Pokharel, Dipendra Khadka, Manoj Sigdel, Naval Kishor Yadav, Shreedhar Acharya, Ramchandra Kafle, Ravindra Mohan Sapkota, Tara Sigdel   +7 more
doaj   +1 more source

"Who receives statins? Variations in physicians’ prescribing patterns for patients with coronary heart disease, dyslipidemia, and diabetes" [PDF]

Our objective is to estimate the extent to which clinical and non-clinical factors are associated with physicians’ prescribing patterns for statins. The data are from the National Ambulatory Medical Care Survey for the period 1992 through 2004. The three
Bryan Townsend, Charles R. Link, Simon Condliffe   +2 more
core  

Genetically Determined Plasma Lipid Levels and Risk of Diabetic Retinopathy: A Mendelian Randomization Study. [PDF]

, 2017
Results from observational studies examining dyslipidemia as a risk factor for diabetic retinopathy (DR) have been inconsistent. We evaluated the causal relationship between plasma lipids and DR using a Mendelian randomization approach.
Asian Genetic Epidemiology Network Consortium, Burdon, Kathryn P, Chen, Ching J, Chen, Yii-Der Ida, Cheng, Ching-Yu, Chong, Yong He, Christiansen, Mark W, Cotch, Mary Frances, Craig, Jamie E, Fan, Qiao, Gan, Alfred, Gudnason, Vilmundur, Guo, Xiuqing, Hai, Yang, Hancock, Heather, Hanis, Craig L, Huang, Yu-Chuen, Hung, Yi-Jen, Ipp, Eli, Jensen, Richard A, Jia, Yucheng, Kaidonis, Georgia, Kim, Jihye, Klein, Barbara EK, Klein, Ronald, Kuo, Jane, Lee, Wen-Jane, Li, Xiaohui, Liao, Wen-Ling, Liew, Gerald, Mitchell, Paul, Penman, Alan, Pollack, Samuela, Price, Alkes, Psaty, Bruce M, Rotter, Jerome I, Sandow, Kevin, Smith, Albert V, Sobrin, Lucia, Stanwyck, Lynn K, Tan, Gavin, Tsai, Fuu-Jen, Wang, Jie Jin, Wong, Tien Yin   +43 more
core   +1 more source

Suggestive evidence of a multi-cytokine resistin pathway in humans and its role on cardiovascular events in high-risk individuals [PDF]

, 2017
In cells and tissues resistin affects IL-1β, IL-6, IL-8, IL-12 and TNF-α expression, thus suggesting the existence of a multi-cytokine "resistin pathway".
Antonucci, Alessandra, Copetti, Massimiliano, De Bonis, Concetta, Di Paola, Rosa, Marucci, Antonella, Menzaghi, Claudia, Ortega Moreno, Lorena, Salvemini, Lucia, Trischitta, Vincenzo   +8 more
core   +1 more source

Dyslipidemia in diffuse large B cell lymphoma based on the genetic subtypes: a single-center study of 259 Chinese patients [PDF]

, 2023
Yi Xu, Huafei Shen, Yuanfei Shi, Yanchun Zhao, Xiaolong Zhen, Jianai Sun, Xueying Li, De Zhou, Chunmei Yang, Jinhan Wang, Xianbo Huang, Juying Wei, Jian Huang, Haitao Meng, Wenjuan Yu, Hongyan Tong, Jie Jin, Wanzhuo Xie   +17 more
openalex   +1 more source

From the Gut to the Brain: Microplastic‐Associated Neurovascular Dysfunction and Implications for Stroke Risk

Advanced Science, EarlyView.
Chronic oral exposure to microplastics may disrupt gut microbiota homeostasis and intestinal barrier integrity, potentially engaging the gut–brain axis and systemic inflammatory responses. These alterations may be associated with impaired blood–brain barrier function, cerebral microvascular dysfunction, and enhanced endothelial inflammation, pro ...
Hongxing Wang, Yujiao He, Pei Zou, Xiaoyi Wang, Gang Peng, Xiangying Deng   +5 more
wiley   +1 more source