Results 91 to 100 of about 339,685 (297)

Suggestive evidence of a multi-cytokine resistin pathway in humans and its role on cardiovascular events in high-risk individuals [PDF]

, 2017
In cells and tissues resistin affects IL-1β, IL-6, IL-8, IL-12 and TNF-α expression, thus suggesting the existence of a multi-cytokine "resistin pathway".
Antonucci, Alessandra, Copetti, Massimiliano, De Bonis, Concetta, Di Paola, Rosa, Marucci, Antonella, Menzaghi, Claudia, Ortega Moreno, Lorena, Salvemini, Lucia, Trischitta, Vincenzo   +8 more
core   +1 more source

Hepatoma‐Derived Growth Factor Coordinates STAT3 Pathway and Exosome‐Mediated Intrahepatic Crosstalk to Control Hepatic Steatosis and MASLD

Advanced Science, EarlyView.
Hepatic HDGF as a key mediator in coordinating hepatic steatosis and intrahepatic crosstalk in MASLD. Activation of HDGF facilitates its interaction with both STAT3 and S6K1, driving the S6K1‐dependent STAT3 phosphorylation and subsequently enhancing hepatic lipogenesis.
Jian Wen, Dong Ding, Zengpeng Zheng, Xufeng Chen, Wenjing Li, Jiaxin Shen, Zhiwei Huang, Peng Tan, Junjie Bai, Xia Fang, Baofang Xing, Puyuan Hu, Linghao Xu, Haokai Yu, Yixi Wang, Zongzhe Jiang, Yang Long, Tiejun Zhou, Mingxin Ye, Yu Jiang, Aoyuan Cui, Hong Li, Qiurong Ding, Yong Xu, Yu Li, Weitong Su, Feng Shen, Chenlin Gao, Wenguang Fu   +28 more
wiley   +1 more source

Adaptation of 2016 European Society of Cardiology/European Atherosclerosis Society guideline for lipid management to Indian patients – A consensus document

Indian Heart Journal, 2018
In the year 2016, European Society of Cardiology/European Atherosclerosis Society (ESC/EAS) guidelines provided recommendations on dyslipidemia management. The recommendation from these guidelines are restricted to European subcontinent.
Saumitra Ray, J.P.S. Sawhney, M.K. Das, Jyoti Deb, Peeyush Jain, Sivakadaksham Natarajan, K.K. Sinha   +6 more
doaj   +1 more source

Clinical guidelines as plans: An ontological theory [PDF]

, 2006
Clinical guidelines are special types of plans realized by collective agents. We provide an ontological theory of such plans that is designed to support the construction of a framework in which guideline-based information systems can be employed in the ...
Gangemi, Aldo, Kumar, Anand, Pisanelli, Domenica, Smith, Barry, Stefanelli, Mario   +4 more
core   +1 more source

Mechanically Robust Biodegradable Stents With Theragenerative Vascular Responses via Combined 3D Printing and Janus Nanoengineering

Advanced Science, EarlyView.
This work introduces a theragenerative 3D‐printed biodegradable stent with Janus nanoarchitecture for spatially controlled vascular healing. A luminal tantalum ion–implanted surface accelerates endothelialization and hemocompatibility, while an abluminal sirolimus/poly‐L‐lactic acid–tantalum layer provides sustained drug release and suppresses smooth ...
Jong Hwa Seo, Dong‐Sung Won, Hyun Lee, Seojoon Bang, Hyeong Seok Kang, Ju Yeong Gwon, Chan Ho Moon, Ji Won Kim, Yubeen Park, Minho Kang, Dong Yun Lee, Donghyun Lim, Kisuk Yang, Gi Doo Cha, Soo‐Hong Lee, Tae‐Sik Jang, Seokbeom Kim, Jun‐Kyu Park, Jung‐Hoon Park, Hyun‐Do Jung   +19 more
wiley   +1 more source

Genetic Association Between Insulin Resistance And Total Cholesterol In Type 2 Diabetes Mellitus - A Preliminary Observation [PDF]

, 2005
We investigated the degree of genetic association between insulin resistance (IR) with type 2 diabetes mellitus (DM) and abnormalities in lipid metabolism in 42 patients.
Gunasekara Sudari Wijewickrama, Hettihewa Lukshmy Menik, Imendra Kotapola, Jayasinghe Sudheera Sammanthi, Palangasinghe Shalika, Weerarathna Thilak Priyantha   +5 more
core   +1 more source

Cardiovascular disease risk factor responses to a type 2 diabetes care model including nutritional ketosis induced by sustained carbohydrate restriction at 1 year: An open label, non-randomized, controlled study [PDF]

, 2018
Additional file 1: Table S1. Detailed baseline characteristics for participants in the continuous care intervention (CCI) and usual care (UC ...
Ballard, Kevin D, Bhanpuri, Nasir H, Campbell, Wayne W, Hallberg, Sarah J, McCarter, James P, McKenzie, Amy L, Phinney, Stephen D, Volek, Jeff S, Williams, Paul T   +8 more
core   +4 more sources

Hyperlipidemia Aggravates Alveolar Bone Loss via Periodontal Ligament Stem Cell Ferroptosis Through GSK3β Dependent Ubiquitin‐Mediated NRF2 Degradation

Advanced Science, EarlyView.
Lipid metabolic stress triggers ferroptosis in PDLSCs through the GSK3β/NRF2 pathway, thereby aggravating periodontal bone loss. Upregulated GSK3β promotes NRF2 ubiquitination and proteasomal degradation via β‐TrCP, suppressing NRF2 nuclear translocation and antioxidant target expression.
Yuxiao Zhang, Xiangyao Wang, Yaxin Wu, Liping Liu, Gaoshaer Nuerlan, Ahsawle Ozathaley, Xiaorui Zhang, Jinping Wang, Bowen Yang, Jing Mao, Yan Liu, Shiqiang Gong   +11 more
wiley   +1 more source

HDL-replacement therapy: From traditional to emerging clinical applications

Atherosclerosis Plus
The unique and multifaceted properties of high-density lipoproteins (HDL)—ranging from cholesterol efflux to anti-inflammatory, anti-oxidant, and immunomodulatory effects—have prompted their direct use, particularly in cardiovascular ischemic conditions ...
Cesare Riccardo Sirtori, Giulia Cincotto, Sofia Castiglione, Chiara Pavanello   +3 more
doaj   +1 more source

Prevalence of anginal symptoms and myocardial ischemia and their effect on clinical outcomes in outpatients with stable coronary artery disease: data from the international observational CLARIFY registry [PDF]

, 2014
Importance: In the era of widespread revascularization and effective antianginals, the prevalence and prognostic effect of anginal symptoms and myocardial ischemia among patients with stable coronary artery disease (CAD) are unknown.<p></p>
Al-Zaibag, Muayed, Dorian, Paul, Ferrari, Roberto, Ford, Ian, Fox, Kim M., Greenlaw, Nicola, Hu, Dayi, Shalnova, Svetlana, Sokn, Fernando José, Steg, Philippe Gabriel, Tardif, Jean-Claude, Tendera, Michal   +11 more
core   +1 more source