Results 71 to 80 of about 339,685 (297)

Genetically Determined Plasma Lipid Levels and Risk of Diabetic Retinopathy: A Mendelian Randomization Study. [PDF]

, 2017
Results from observational studies examining dyslipidemia as a risk factor for diabetic retinopathy (DR) have been inconsistent. We evaluated the causal relationship between plasma lipids and DR using a Mendelian randomization approach.
Asian Genetic Epidemiology Network Consortium, Burdon, Kathryn P, Chen, Ching J, Chen, Yii-Der Ida, Cheng, Ching-Yu, Chong, Yong He, Christiansen, Mark W, Cotch, Mary Frances, Craig, Jamie E, Fan, Qiao, Gan, Alfred, Gudnason, Vilmundur, Guo, Xiuqing, Hai, Yang, Hancock, Heather, Hanis, Craig L, Huang, Yu-Chuen, Hung, Yi-Jen, Ipp, Eli, Jensen, Richard A, Jia, Yucheng, Kaidonis, Georgia, Kim, Jihye, Klein, Barbara EK, Klein, Ronald, Kuo, Jane, Lee, Wen-Jane, Li, Xiaohui, Liao, Wen-Ling, Liew, Gerald, Mitchell, Paul, Penman, Alan, Pollack, Samuela, Price, Alkes, Psaty, Bruce M, Rotter, Jerome I, Sandow, Kevin, Smith, Albert V, Sobrin, Lucia, Stanwyck, Lynn K, Tan, Gavin, Tsai, Fuu-Jen, Wang, Jie Jin, Wong, Tien Yin   +43 more
core   +1 more source

Alterations of intestinal lipoprotein metabolism in diabetes mellitus and metabolic syndrome [PDF]

, 2015
Diabetes and metabolic syndrome are associated with abnormal postprandial lipoprotein metabolism, with a significant delay in the clearance of many lipid parameters, including triglycerides and chylomicrons.
ARCA, Marcello
core   +1 more source

Macrophage Membrane‐Cloaked, ROS‐Triggered Quercetin Nanocarriers Target Ovarian Lesions to Treat Polycystic Ovary Syndrome

Advanced Healthcare Materials, EarlyView.
The synthesis process of MM@PCD@QNPs and its potential mechanism for treating PCOS. (A) Assembly steps of MM@PCD@QNPs. (B) Synthesis and decomposition of MM@PCD@QNPs. (C) Potential therapeutic mechanisms of MM@PCD@QNPs for PCOS. PCD, PABP conjugated with DEX polymer; QUR, quercetin; CDI, N, N′‐carbonyldiimidazole; DEX, dextran; PABP, 4‐(hydroxymethyl ...
Wenzhu Li, Yu Guan, Nan Song, Feng Zhang, Zhimin Deng, Tailang Yin, Yanbing Yang, João Conde, Wenyi Jin, Zhinang Yin   +9 more
wiley   +1 more source

Triggering the adaptive immune system with commensal gut bacteria protects against insulin resistance and dysglycemia

Molecular Metabolism, 2016
Objective: To demonstrate that glycemia and insulin resistance are controlled by a mechanism involving the adaptive immune system and gut microbiota crosstalk.
Céline Pomié, Vincent Blasco-Baque, Pascale Klopp, Simon Nicolas, Aurélie Waget, Pascale Loubières, Vincent Azalbert, Anthony Puel, Frédéric Lopez, Cédric Dray, Philippe Valet, Benjamin Lelouvier, Florence Servant, Michael Courtney, Jacques Amar, Rémy Burcelin, Lucile Garidou   +16 more
doaj   +1 more source

Prevalence of dyslipidemia and associated risk factors among adults aged ≥35 years in northern China: a cross-sectional study

BMC Public Health, 2020
Background Cardiovascular disease (CVD) prevalence has increased continuously over the last 30 years in China. Dyslipidemia is an important modifiable risk factor in CVD.
Yunfeng Xi, Liwei Niu, Ning Cao, Han Bao, Xiaoqian Xu, Hao Zhu, Tao Yan, Nan Zhang, Liying Qiao, Ke Han, Gai Hang, Wenrui Wang, Xingguang Zhang   +12 more
doaj   +1 more source

Adherence to Antihypertensives in Patients With Comorbid Condition. [PDF]

, 2015
BackgroundComorbidity has been noted as a potential barrier to proper adherence to antihypertensive medications.ObjectivesWe decided to investigate whether comorbidity could significantly affect adherence of Iranian patients with hypertension to their ...
Aerab-Sheibani, Hossein, Bahremand, Mostafa, Moharramzad, Yashar, Morisky, Donald E, Nikdoust, Farahnaz, Saadat, Habibollah, Saadat, Zahra, Shobeiri, Elham   +7 more
core   +1 more source

Extracellular Vesicles Modulation by an Adiponectin Receptor Agonist Provides Cardioprotection for Myocardial Ischemic Injury

Advanced Healthcare Materials, EarlyView.
This study demonstrates that ALY688, a drug mimicking the heart‐protective hormone adiponectin, reduces myocardial ischemia injury. ALY688 increases the production of extracellular vesicles, which carry protective cargo including adiponectin itself.
Jialing Tang, Wing Yan Chung, Serena M. Pulente, Yubin Lei, Khang Nguyen, Eddie Tam, Nadya M. Morrow, Ilka Lorenzen‐Schmidt, Fengxia Xiao, Augusto Zani, Dylan Burger, Hye Kyoung Sung, Erin E. Mulvihill, Gary Sweeney   +13 more
wiley   +1 more source

Associations of Perirenal Fat Thickness with Renal and Systemic Calcified Atherosclerosis. [PDF]

, 2020
BackgroundWe investigated associations between perirenal fat thickness and atherosclerotic calcification in six different vascular beds.MethodsUsing a community-based cohort (n=3,919), perirenal fat thickness was estimated from computed tomography scans.
Allison, Matthew A, Criqui, Michael H, Denenberg, Julie O, Koo, Bo Kyung, Wright, C Michael   +4 more
core  

The associations of adipokines with selected markers of the renin-angiotensinogen-aldosterone system: the multi-ethnic study of atherosclerosis. [PDF]

, 2015
Among obese individuals, increased sympathetic nervous system (SNS) activity results in increased renin and aldosterone production, as well as renal tubular sodium reabsorption.
Allison, MA, Cushman, M, Jenny, NS, McClelland, RL, Rifkin, D   +4 more
core   +3 more sources

Farnesyltransferase Deficiency in Cardiomyocytes Initiates Senescence and Contributes to Cardiac Fibrosis

Advanced Science, EarlyView.
Lipid overload suppresses SREBF2‐mediated FNTB expression, leading to defective Lamin A maturation and nuclear envelope instability. This nuclear catastrophe triggers a pro‐fibrotic senescence program in cardiomyocytes. Notably, restoring nuclear integrity via AAV9‐based gene therapy effectively attenuates cardiac remodeling, identifying the ...
Yuxiao Chen, Lian Lou, Xuan Zhang, Lin Yan, Qi Zhang, Wen Shi, Jie Ding, Xu Lin, Rong Jiang, Shuo Liu, Thida Sok, Pengli Wang, Yun Mou, Jie Han, Shenjiang Hu, Xiaogang Guo, Jian Yang   +16 more
wiley   +1 more source