Results 61 to 70 of about 144,659 (249)

Iron‐dependent lysosomal LDL oxidation induces the expression of scavenger receptor A in human THP‐1 monocytes

open access: yesFEBS Open Bio, EarlyView.
In human monocytic cells THP‐1, a limited uptake of native—not oxidized—LDL/VLDL induced expression of scavenger receptor A and cellular adhesion. Induction was inhibited by lysosomotropic (WR‐1065) and lipophilic (BHT) antioxidants and by siRNAs against ferritinophagy.
Martina Čierna   +4 more
wiley   +1 more source

Use of Best Practice Alerts to Improve Adherence to Evidence-Based Screening in Pediatric Diabetes Care [PDF]

open access: yes, 2019
Background: Youth with type 1 diabetes (T1D) are at increased risk for comorbid autoimmune conditions and long-term complications. To help with early identification of these complications, the American Diabetes Association (ADA) has published evidence ...
Bartz, Sara K   +3 more
core   +1 more source

Relationship between Estimated Glomerular Filtration Rate (eGFR) and Metabolic Syndrome in Japanese [PDF]

open access: yes, 2010
We investigated the link between renal function as evaluated by estimated glomerular filtration rate (eGFR) and metabolic syndrome in Japanese.
Makino, Hirofumi   +3 more
core   +1 more source

Development of a Disease Model for Predicting Postoperative Delirium Using Combined Blood Biomarkers

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Postoperative delirium, a common neurocognitive complication after surgery and anesthesia, requires early detection for potential intervention. Herein, we constructed a multidimensional postoperative delirium risk‐prediction model incorporating multiple demographic parameters and blood biomarkers to enhance prediction accuracy ...
Hengjun Wan   +7 more
wiley   +1 more source

Perbedaan Asupan Lemak, Lingkar Pinggang dan Persentase Lemak Tubuh pada Wanita Dislipidemia dan Non Dislipidemia [PDF]

open access: yes, 2014
Differences of fat intake, waist circumference and percentage of bodt fat in dyslipidemia and non dyslipidemia adult women: Heart disease is the leading cause of death in several countries in the world . One of the major risk factors for heart disease is
Ben D. Gamari (1932061)   +6 more
core   +3 more sources

Risk of Hepatotoxicity in Patients With Gout Treated With Febuxostat or Benzbromarone: A Propensity Score–Matched Cohort Study

open access: yesArthritis Care &Research, EarlyView.
Objective The objective of this study was to evaluate and compare the risk of hepatotoxicity associated with the use of febuxostat and benzbromarone in patients with gout. Methods New users of febuxostat or benzbromarone with monitoring of liver function at least three times in a year after initiation of the study drugs were identified from an ...
Wenyan Sun   +8 more
wiley   +1 more source

Alterations of intestinal lipoprotein metabolism in diabetes mellitus and metabolic syndrome [PDF]

open access: yes, 2015
Diabetes and metabolic syndrome are associated with abnormal postprandial lipoprotein metabolism, with a significant delay in the clearance of many lipid parameters, including triglycerides and chylomicrons.
ARCA, Marcello
core   +1 more source

Adenosine Monophosphate Improves Lipolysis in Obese Mice by Reducing DNA Methylation via ADORA2A Activation by Ecto‐5′‐Nucleotidase (CD73)

open access: yesAdvanced Science, Volume 12, Issue 14, April 10, 2025.
In this study, the improvement effect of AMP on obesity can be attributed to the conversion of extracellular AMP to ADO through ADORA2A activation by CD73, which can promote lipolysis by reducing DNA methylation level and enhancing HSL gene transcription. These findings show the great potential of AMP in improving obesity.
Zhijuan Cui   +12 more
wiley   +1 more source

Vascular neurocognitive disorders and the vascular risk factors [PDF]

open access: yes, 2018
Dementias are clinical neurodegenerative diseases characterized by permanent and progressive transformation of cognitive functions such as memory, learning capacity, attention, thinking, language, passing judgments, calculation or orientation.
Albu, Carmen V.   +7 more
core   +4 more sources

ACSL1 Aggravates Thromboinflammation by LPC/LPA Metabolic Axis in Hyperlipidemia Associated Myocardial Ischemia‐Reperfusion Injury

open access: yesAdvanced Science, Volume 12, Issue 11, March 20, 2025.
In hyperlipidemic states, Long‐chain fatty acyl‐CoA synthetase 1 (ACSL1) is consistently induced, which then reprogrammes the lipid metabolism in monocytes. The accumulation of monocyte‐secreted lysophosphatidylcholine (LPC)/lysophosphatidic acid (LPA) enhances the thrombotic and inflammatory processes Then LPC/LPA axis promots activation and NETosis ...
Shuai Jiang   +12 more
wiley   +1 more source

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