Results 91 to 100 of about 271,809 (300)

Navigating adverse immunostimulation: A practical guide for clinical researchers

British Journal of Clinical Pharmacology, EarlyView.
Problem Setting As drug development moves towards more complex products, early clinical development programmes are increasingly hampered by unwanted and/or unexpected activation of the immune system (adverse immune stimulation, AIS). Solution At the Centre for Human Drug Research, we have introduced standardized procedures to make AIS manageable, while
Juliette A. van den Noort, Anouk C. Meijs, Naomi B. Klarenbeek, Matthijs Moerland   +3 more
wiley   +1 more source

Adverse immunostimulation in early phase clinical trials: Key findings and recommendations based on the investigator's clinical experience

British Journal of Clinical Pharmacology, EarlyView.
Problem setting The emergence of therapeutic proteins has coincided with an increase of acute adverse immunostimulation (AIS). AIS has occured in clinical trials despite compliance with regulatory guidelines on preclinical evaluation and its incidence is anticipated to increase even further.
Juliette A. van den Noort, Marella C. E. van Ruissen, Lisanne C. A. Smidt, Naomi B. Klarenbeek, Philip H. K. Kremer, Manon A. A. Jansen, Jacobus Burggraaf, Joop M. A. van Gerven, Matthijs Moerland   +8 more
wiley   +1 more source

Visualization of Cardiac Thrombus by Bedside Ultrasound

Western Journal of Emergency Medicine, 2013
[West J Emerg Med. 2013;14(6):637.]
Ünlüer, Erden E., Kuday, Eylem, Bayata, Serdar   +2 more
doaj   +1 more source

Man with dyspnea [PDF]

JACEP Open, 2020
Mark Favot, Luke Collins
openaire   +3 more sources

Effect of dyspnea on frailty stages and related factors in Taiwanese men with COPD

, 2018
Pei-Ju Chen,1 Kuang-Yao Yang,2,3 Wann-Cherng Perng,4 Kuan-Chia Lin,5,6 Kwua-Yun Wang7 1School of Nursing, National Yang-Ming University, Taipei, Taiwan, Republic of China; 2Department of Chest Medicine, Taipei Veterans General Hospital, Taipei, Taiwan ...
Yang KY, Chen PJ, Wang KY, Lin KC, Perng WC   +4 more
core  

Translation and Validation of the Multidimensional Dyspnea-12 Questionnaire

, 2018
Introduction Dyspnea is a multidimensional symptom, but this multidimensionality is not considered in most dyspnea questionnaires. The Dyspnea-12 takes a multidimensional approach to the assessment of dyspnea, specifically the sensory and the affective ...
Agüero Balbín, Ramón, Agüero Calvo, Juan, Juan Agüero Calvo, Ramón Agüero Balbín, Abascal Bolado, Beatriz, Hernando Hernando, Mercedes, Amado Diago, Carlos Antonio, Puente Bats, Irene, Luis Puente Maestu, Carlos Antonio Amado Diago, Irene Puente Bats, Puente Maestu, Luis, Beatriz Abascal Bolado, Mercedes Hernando Hernando   +13 more
core   +1 more source

Efficacy, safety and cost‐effectiveness of CAR‐T therapy

British Journal of Clinical Pharmacology, EarlyView.
CAR T‐cells demonstrate high efficacy in blood cancers, including ALL, MM and DLBCL. Innovations target solid tumours despite challenges such as antigen escape. Combination therapies enhance the delivery and infiltration of CAR T cells. Toxicity, cost and resistance remain major barriers to clinical use.
Emina Karahmet Sher, Amina Džidić‐Krivić, Emma Pinjic, Nejra Selak, Kanita Omerbasic, Alexandar Chupin, Andrej Belancic, Almir Fajkic   +7 more
wiley   +1 more source

Use of Ecological Momentary Assessment to Measure Dyspnea in COPD [PDF]

Sarah N Miller,1 Michelle Nichols,1 Ronald J Teufel II,2 Erin P Silverman,3 Marta Walentynowicz4 1College of Nursing, Medical University of South Carolina, Charleston, South Carolina, SC, USA; 2College of Medicine, Medical University of South Carolina ...
Miller SN, Teufel II RJ, Nichols M, Silverman EP, Walentynowicz M   +4 more
core  

Basophilic Stippling Unmasks Pyrimidine 5′‐Nucleotidase Deficiency in a G6PD‐Deficient Patient

American Journal of Hematology, EarlyView.
Victor Bobée, Stéphane Moutereau, Maïssa Souissi, Pierre Lebreton, Loïc Garcon   +4 more
wiley   +1 more source

Acute toxicity of ADB‐CHMINACA ‐ a case series of patients with pronounced central nervous symptoms including the posterior reversible encephalopathic syndrome

British Journal of Clinical Pharmacology, EarlyView.
Aim This report presents a series of 16 patients who were admitted to the emergency department following confirmed intake of the potent synthetic cannabinoid ADB‐CHMINACA. Methods The cases are drawn from a prospective observational study following the recreational use of synthetic cannabinoids.
Maren Hermanns‐Clausen, Michaela Sommer, Annette Zschiesche, Verena Angerer, Martin Scheu, Florian Eyer, Johannes Nadler, Volker Auwärter   +7 more
wiley   +1 more source