Results 101 to 110 of about 271,809 (300)

Evaluating the (comparative) safety profile of the novel oral polio vaccine type 2 using individual case safety reports in VigiBase

British Journal of Clinical Pharmacology, EarlyView.
Aim Novel oral polio vaccine type 2 (nOPV2) was used under the WHO emergency use listing for circulating vaccine‐derived polio virus (cVDPV) outbreaks from 2021 to 2023. We assessed nOPV2 adverse events following immunization (AEFIs) and compared its safety profile to other vaccines using VigiBase.
Comfort Kunak Ogar, Malede Mequanent Sisay, Leonardo Roque‐Pereira, Christine Leopold, Patrick C. Souverein, Aukje K. Mantel‐Teeuwisse, Marie L. De Bruin   +6 more
wiley   +1 more source

Dispnede Güvenli Opioid Kullanımı ve Bakımı

Yoğun Bakım Hemşireliği Dergisi, 2023
ÖZETDispne yaşam kalitesini ve temel insan ihtiyaçlarını olumsuz yönde etkileyen yaygın subjektif bir semptomdur. Dispnenin nedenleri arasında akciğer hastalıkları başta olmak üzere kardiyovasküler hastalıklar, kanser, nöromüsküler, metabolik, nörolojik,
Dilek Aygin, Büşra Ateş, Derya Kurak
doaj  

Acute effects of THC and a CBD+THC combination on cardiovascular haemodynamics and respiratory muscle activity during loaded breathing in healthy adults: A randomized placebo‐controlled crossover study

British Journal of Clinical Pharmacology, EarlyView.
Aims This study aimed to evaluate the acute effects of cannabidiol plus tetrahydrocannabinol (CBD+THC) and tetrahydrocannabinol (THC) oils on cardiovascular haemodynamics, respiratory muscle activity and peripheral tissue perfusion in healthy adults. Methods In this randomized, double‐blind, crossover trial, participants received orally administered ...
Edna Karla Ferreira Laurentino, Marina Lyra L. C. Fagundes, Bruno Lobão Soares, Rodrigo Torres‐Castro, Matias Otto‐Yañez, Emerson Arcoverde Nunes, Matheus Freitas Fernandes Pedrosa, Jéssica Danielle Medeiros da Fonsêca, Vanessa R. Resqueti, Guilherme Augusto de Freitas Fregonezi   +9 more
wiley   +1 more source

[Clinical utility of natriuretic peptdies in dyspnea]

, 2009
Natriuretic peptides (NP) are simple and rapid cardiac biomarkers that quantify hemodynamic cardiac stress and heart failure. Heart failure is a common cause of dyspnea, therefore improvements in the diagnosis of heart failure have a major impact on the ...
Müller, Christian, Christian Müller
core   +1 more source

Adaptive imatinib regimens can mitigate cumulative toxicity while sustaining hemodynamic benefit: A model‐based simulation of the positioning imatinib for pulmonary arterial hypertension trial

British Journal of Clinical Pharmacology, EarlyView.
ABSTRACT Aims Imatinib improves hemodynamics in pulmonary arterial hypertension (PAH), but dose‐dependent toxicity has limited its clinical development. We aimed to quantify the dose–efficacy–toxicity relationship and evaluate alternative dosing strategies using data from the PIPAH trial.
Medhat M. Said, Robert B. de Mooij, Dian Jiao, Reitze J. Ovelgonne, Rami Biram, Juan Delgado‐SanMartin, Alexander M. K. Rothman, Sofia S. Villar, Andreas A. Roussakis, Jurjan Aman, Ron A. A. Mathôt, Eleonora L. Swart, Martin R. Wilkins, Imke H. Bartelink   +13 more
wiley   +1 more source

Disproportionate dyspnea in a patient with pneumonia

, 2017
In severe pneumonia, dyspnea occurs due to hypoxia. Usually, in pneumonia, dyspnea is proportional to the extent of lung parenchymal lesion. When a patient with pneumonia presents with disproportionate dyspnea, other causes for dyspnea should be ...
Y Madhusudan, Alka C Bhat, Vishnu Sharma Moleyar, D S Harsha   +3 more
core   +1 more source

Safety and pharmacokinetics of inhaled aloxistatin: A first‐in‐human phase 1 dose escalation trial

British Journal of Clinical Pharmacology, EarlyView.
Aims Aloxistatin (E64d) is a membrane‐permeable cysteine protease inhibitor prodrug that is converted by esterases to the active metabolite E64c (loxistatin). This first‐in‐human study evaluated the safety, tolerability and pharmacokinetics of single ascending doses of inhaled E64d in healthy volunteers.
Sebastian Fähndrich, Franziska Friedrich, Daniel Soriano, Jona Gjeloshi, Björn C. Frye, Xuan Phuoc Nguyen, Lydia Herbstritt, Caroline von Spee‐Mayer, Britta Lang, Fabrice Nollevaux, Andreas Hoheisel, Dorothee Winterberg, Armin Braun, Thomas Epting, Christine Contini, Karl Winkler, Thomas Reinheckel, Franziska C. Trudzinski, Gernot Rohde, Daiana Stolz, Robert Bals, Martin J. Hug, Sebastian Wirtz, Christoph Peters, Carolin Jenkner   +24 more
wiley   +1 more source

Drug-induced dyspnea versus cystic fibrosis exacerbation: a diagnostic dilemma

, 2017
Saqib Walayat,1 Nooreen Hussain,1 Jaymon Patel,1 Faiz Hussain,2 Preeti Patel,1 Sonu Dhillon,1 Bhagat Aulakh,3,4 Subramanyam Chittivelu3 1Department of Internal Medicine, University of Illinois College of Medicine at Peoria, Peoria, 2Department of ...
Patel P, Dhillon S, Walayat S, Aulakh B, Hussain F, Hussain N, Chittivelu S, Patel J   +7 more
core  

Palliative management of refractory dyspnea in COPD [PDF]

, 2006
Auckland, New ...
Abernethy, Amy Pickar, Currow, David Christopher, Uronis, H E   +2 more
core  

Modified Medical Research Council scale vs Baseline Dyspnea Index to evaluate dyspnea in chronic obstructive pulmonary disease

, 2015
Thierry Perez,1 Pierre Régis Burgel,2 Jean-Louis Paillasseur,3 Denis Caillaud,4 Gaetan Deslée,5 Pascal Chanez,6 Nicolas Roche2 For the INITIATIVES BPCO Scientific Committee 1Clinique des Maladies Respiratoires, CHRU de Lille, Universit ...
Paillasseur JL, Perez T, Caillaud D, Deslée G, Burgel PR, Chanez P, Roche N   +6 more
core