Results 121 to 130 of about 48,181 (245)

Fast Myosin Binding Protein‐C Is a Vital Regulator in Young and Aged Fast Skeletal Muscle Homeostasis

Journal of Cachexia, Sarcopenia and Muscle, Volume 16, Issue 6, December 2025.
ABSTRACT Background Skeletal muscle plays a vital role in voluntary movement and locomotion. Fast‐twitch muscle fibres are characterized by their rapid contraction kinetics, high‐force generation and a distinct gene expression profile compared to slow‐twitch fibres.
Akhil Baby, Kalyani Ananthamohan, Brenna N. McIntyre, Sankar Natesan, Taejeong Song   +4 more
wiley   +1 more source

Utrophin Compensates dystrophin Loss during Mouse Spermatogenesis

Scientific Reports, 2017
Duchenne muscular dystrophy (DMD) is an X-linked genetic disorder resulting from mutations in the dystrophin gene. The mdx/utrn −/− mouse, lacking in both dystrophin and its autosomal homologue utrophin, is commonly used to model the clinical symptoms of
Hung-Chih Chen, Yu-Feng Chin, David J. Lundy, Chung-Tiang Liang, Ya-Hui Chi, Paolin Kuo, Patrick C. H. Hsieh   +6 more
doaj   +1 more source

834. Systemic Delivery of Immunosuppressant Proteins and Dystrophin by High-Capacity Adenoviral Vector Provides Sustained Expression of Dystrophin in Skeletal Muscle of Mdx Mice [PDF]

, 2003

openalex   +1 more source

Anabolic Effects of Salbutamol Are Lost Upon Immobilization

Journal of Cachexia, Sarcopenia and Muscle, Volume 16, Issue 6, December 2025.
ABSTRACT Background Periods of muscle disuse occur during hospitalization, illness or the recovery from (sports) injury and lead to a rapid loss of muscle mass and the development of insulin resistance. Salbutamol is a fast‐acting β2‐adrenoreceptor agonist that may improve muscle protein synthesis and insulin sensitivity during experimental muscle ...
Jelle C. B. C. de Jong, Tom S. O. Jameson, Rob C. Andrews, Mandy V. Dunlop, Doaa R. Abdelrahman, Andrew J. Murton, Martien P. M. Caspers, Nicole Worms, Anita van Nieuwkoop, Nanda Keijzer, Qihan Cheng, Bruno Guigas, Esther van Duijn, Wouter H. J. Vaes, Arie G. Nieuwenhuizen, Jaap Keijer, Benjamin T. Wall, Lars Verschuren, Francis B. Stephens, Anita M. van den Hoek, Marlou L. Dirks   +20 more
wiley   +1 more source

Combined Right Ventricular Preload and Afterload Challenge Induces Contractile Dysfunction and Ventricular Arrhythmia in an Age-dependent Manner in Isolated Hearts of Dystrophin-deficient Mice [PDF]

, 2023
Andrew Behrmann, Jessica Cayton, Matt Hayden, Michelle Lambert, Zahra Nourian, Keith Nyanyo, Laurin M. Hanft, Maike Krenz, Kerry S. McDonald, Timothy L. Domeier   +9 more
openalex   +1 more source

An Isogenic Human Myoblast Cell Model for Cystinosis Myopathy Reveals Alteration of Key Myogenic Regulatory Proteins

Journal of Cachexia, Sarcopenia and Muscle, Volume 16, Issue 6, December 2025.
ABSTRACT Background Cystinosis is a rare multisystem, autosomal recessive disease caused by dysfunction or loss of cystinosin (CTNS), which results in lysosomal cystine accumulation, primarily affecting the kidneys. Advances in renal transplantation, cysteamine treatment and improved medical care have increased life expectancy, revealing additional ...
Louise Medaer, Roger Mora, Zhuoheng Zhou, Nefele Giarratana, Laura Yedigaryan, Rita La Rovere, Elena Levtchenko, Vincent Mouly, Els Verhoeyen, Sebastiaan Eeltink, Achim Treumann, Tim Vervliet, Maurilio Sampaolesi, Rik Gijsbers   +13 more
wiley   +1 more source

1018. Exon Skipping-Mediated Dystrophin Reading Frame Restoration for Small Mutations [PDF]

, 2009

openalex   +1 more source

Small‐Molecule Targeting MuRF1 Protects Against Denervation‐Induced Diaphragmatic Dysfunction: Underlying Molecular Mechanisms

Journal of Cachexia, Sarcopenia and Muscle, Volume 16, Issue 6, December 2025.
ABSTRACT Background Mechanical inactivity rapidly induces diaphragm muscle fibres' contractile dysfunction and atrophy. Diaphragm weakness can impair respiratory function, quality of life and increase risks of morbidity and mortality. Muscle RING‐finger protein‐1 (MuRF1) expression is upregulated during denervation and muscle inactivity and is known to
Fernando Ribeiro, Paulo R. Jannig, Siegfried Labeit, Anselmo S. Moriscot   +3 more
wiley   +1 more source

Dystrophin expression in the mdx mouse restored by stem cell transplantation [PDF]

, 1999
Emanuela Gussoni, Yuko Soneoka, Corinne D. Strickland, Elizabeth A. Buzney, Mohamed K. Khan, Alan F. Flint, Louis M. Kunkel, Richard C. Mulligan   +7 more
openalex   +1 more source

C2C12‐Derived ApoVs Promote Skeletal Muscle Development and Ameliorate Age‐Related Muscle Loss Through Igf1r/PI3K/AKT/mTOR Pathway

Journal of Cachexia, Sarcopenia and Muscle, Volume 16, Issue 6, December 2025.
ABSTRACT Background Apoptosis coincides with the differentiation of skeletal myoblasts, and numerous studies have shown that the apoptotic activity is required for myogenic differentiation. Although the role of apoptosis in skeletal muscle differentiation has been well documented, its mechanism is largely unknown.
Aiwen Jiang, Yi Liu, Luyao Wang, Haifei Wang, Shenglong Wu, Wenbin Bao   +5 more
wiley   +1 more source