Results 131 to 140 of about 28,350 (246)

TAK1 Regulates Skeletal Muscle Mass, Hypertrophic Signaling, and Metabolic Homeostasis in Male and Female Mice

The FASEB Journal, Volume 40, Issue 10, 31 May 2026.
Targeted inactivation of TAK1 induces more rapid muscle atrophy in male mice compared to female mice. In addition, loss of TAK1 impairs mechanical overload–induced phosphorylation of p70S6K and rpS6, leading to blunted muscle hypertrophic growth. TAK1 inactivation also promotes lipid accumulation while reducing fatty acid metabolism in skeletal muscle ...
Meiricris Tomaz da Silva, Aniket S. Joshi, Anirban Roy, Troy A. Hornberger, Ashok Kumar   +4 more
wiley   +1 more source

Fibrotic pathways in the dystrophin deficient heart

, 2009
Duchenne muscular dystrophy is the most prevalent and severe of the muscular dystrophies. A hallmark of dystrophic muscle is fibrosis which is a result of chronic cycles of degeneration and regeneration. Cardiac fibrosis interferes with contractility and
Wakefield, Amanda
core  

A combinatorial oligonucleotide therapy to improve dystrophin restoration and dystrophin-deficient muscle health

Molecular Therapy: Nucleic Acids
Despite the proven safety of dystrophin-targeting phosphorodiamidate morpholino oligomer (PMO) therapy, poor delivery of the PMOs limit the efficacy of this dystrophin restoring gene therapy for Duchenne muscular dystrophy (DMD).
Young Jae Moon, Ravi Hindupur, Iteoluwakishi H. Gamu, Nikki M. McCormack, Fatima Shaikh, James S. Novak, Jyoti K. Jaiswal   +6 more
doaj   +1 more source

Immunologic investigations into transgene directed immune-mediated myositis following delandistrogene moxeparvovec gene therapy

Scientific Reports
Delandistrogene moxeparvovec is an rAAVrh74 vector-based gene transfer therapy that delivers a transgene encoding delandistrogene moxeparvovec micro-dystrophin, an engineered, functional form of dystrophin shown to stabilize or slow disease progression ...
Rachael A. Potter, Ida H. Moeller, Sohrab Khan, Hélène Haegel, Andreas Hollenstein, Guido Steiner, Christoph Wandel, Alexander P. Murphy, Damon R. Asher, Emanuel Palatinsky, Danielle A. Griffin, Stefanie Mason, Susan T. Iannaccone, Craig M. Zaidman, Louise R. Rodino-Klapac   +14 more
doaj   +1 more source

SAP97 and dystrophin macromolecular complexes determine two pools of cardiac sodium channels Nav1.5 in cardiomyocytes

, 2011
The cardiac sodium channel Na(v)1.5 plays a key role in excitability and conduction. The 3 last residues of Na(v)1.5 (Ser-Ile-Val) constitute a PDZ-domain binding motif that interacts with the syntrophin-dystrophin complex. As dystrophin is absent at the
Ogrodnik, Jakob, Hatem, S., Bittihn, P. ; https://orcid.org/, Balse, E., Hugues Abriel, Ogrodnik, J., Maxime Albesa, Hugues, A., Hatem, Stéphane N., Luther, Stefan, Zmoos, Anne-Flore, Séverine Petitprez, Philip Bittihn, El-Haou, S., Jakob Ogrodnik, Raad, Nour, Said El-Haou, Coulombe, A., Stéphane N. Hatem, Albesa, Maxime, Luther, S., Lehnart, Stephan E., El-Haou, Said, Albesa, M., Anne-Flore Zmoos, Bittihn, Philip, Hugues, Abriel, Petitprez, S., Elise Balse, Abriel, Hugues, Balse, Elise, Nour Raad, Stephan E. Lehnart, Zmoos, A., Coulombe, Alain, Alain Coulombe, Lehnart, Stephan E, Lehnart, S., Petitprez, Séverine, Hatem, Stéphane N, Raad, N., Stefan Luther   +41 more
core   +1 more source

Efficiency of antisense-mediated exon skipping in normal and mutated DMD genes [PDF]

, 2009
In questo lavoro di tesi si è andati ad indagare l’efficacia di alcuni oligonucleotidi antisenso progettati per escludere alcuni esoni da sequenze “sane”.
Schiavo, Andrea Alex
core  

Current knowledge of dystrophin and dystrophin-associated proteins in the retina

, 2011
Dramatical development of molecular genetics has been disclosing the molecular mechanism of Duchenne muscular dystrophy (DMD) and Becker muscular dystrophy (RMD).
Ohno, S., Ueda, Hideho, Baba, T.
core  

Dystrophin [PDF]

, 2020
openaire   +1 more source

Gene Editing Strategies for Duchenne Muscular Dystrophy: From Molecular Mechanisms to Clinical Translation. [PDF]

Cells
Siddika A, Rousseau J, Veillette F, Bouchard C, Lu Y, Tremblay JP.   +5 more
europepmc   +1 more source

The atomic structure of human dystrophin spectrin-like repeat 24. [PDF]

Acta Crystallogr F Struct Biol Commun
Streeter O, Shi K, Bui H, Aihara H, Ervasti JM, Evans R, Muretta JM.   +6 more
europepmc   +1 more source