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Expression of Dystrophins and the Dystrophin-Associated-Protein Complex by Pituicytes in Culture
Neurochemical Research, 2011The dystrophin-associated-protein complex (DAPC) has been extensively characterized in the central nervous system where it is localized both in neuronal and glial cells. Few studies have characterized this complex in the neurohypophysis. To further study this complex in pituicytes, the resident astroglia of the neurophypophysis, we used adult pituicyte
Serge Picaud +11 more
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Dystrophin and dystrophin‐related protein in the brains of normal and mdx mice
Muscle & Nerve, 1994AbstractTo clarify the localization and characterization of dystrophin and dystrophin‐related protein (DRP) in the brains of normal and mdx mice, we carried out immunostaining and immunoblotting studies using four region‐specific antidystrophin and anti‐DRP antibodies. With immunostaining, punctate immunoreactivity of dystrophin was seen along the cell
Hiroaki Naoe +7 more
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Dystrophin and dystrophin-related proteins: A review of protein and RNA studies
Neuromuscular Disorders, 1993The analysis of dystrophin gene expression has led to the identification of multiple transcripts and varying isoforms. The data indicate that transcription of the dystrophin gene occurs from several promoters, which involves developmental and tissue-dependent regulation.
Donald R. Love +4 more
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Dystrophin is not essential for the integrity of the cytoskeleton
Acta Neuropathologica, 1994Dystrophin is localized, in normal muscle fibers, on the cytoplasmic surface of the sarcolemma. The function of this protein is not known but, according to its structure and intracellular distribution, it seems likely that dystrophin interacts with other cytoskeletal proteins to form a complex linkage between myofibrils, sarcolemma and extracellular ...
MASSA, ROBERTO +4 more
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Dystrophin and dystrophin-related protein expression in Torpedo marmorata electric organ
Neuroscience Letters, 1993The presence of different dystrophin-related protein forms was investigated in electric organ as compared to cardiac, white or red skeletal muscles from Torpedo marmorata. Two strategies were followed. First, we used specific C-terminal dystrophin and dystrophin-related protein monoclonal antibodies which we characterized in the present study.
Jean J. Leger +3 more
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Dystrophin: A clinical perspective
Pediatric Neurology, 1990Dystrophin, the protein product of the gene related to Duchenne and Becker muscular dystrophies, is a large cytoskeletal protein associated with the muscle fiber membrane. Recently identified dystrophin-related myopathies affecting animals can serve as experimental models for human disease.
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Human dystrophin gene transfer: genetic correction of dystrophin deficiency
1993Somatic gene therapy, as generally conceived, involves reconstituting a biological function by adding a normal gene to somatic, i.e. non-germline, cells which are genetically deficient in that gene product (Friedmann, 1989). Single gene or Mendelian disorders which are recessive (autosomal or X-linked) are particularly attractive candidates for such a ...
George Dickson, Matthew G. Dunckley
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Dystrophin: The protein product of the duchenne muscular dystrophy locus
Cell, 1987Eric P. Hoffman +2 more
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