Results 81 to 90 of about 534,393 (266)

Efficient Lewis Acid Systems for the A3 Coupling reaction

, 2018
Efficient Lewis Acid Systems for the A3 Coupling reaction Cimarelli C., a Navazio F.,a Rossi F. V.a, Del Bello F., Marcantoni E.a aSchool of Science and Technology, Chemistry Division, University of Camerino, Via S.
Marcantoni E., Del Bello F., Cimarelli C., Navazio F., Rossi F. V.   +4 more
core  

Quantification of the Nucleophilicities of 3-X-Thiophenes: Highlighting the Hyperortho Correlation

Journal of Chemistry, 2020
Kinetics studies for the coupling reactions of the 3-X-thiophene 1a-c (X = CH3, H and Br) with the electrophiles 2a and 3a-c have been investigated in acetonitrile at 20°C The second-order rate constants have been employed to determine the ...
W. Gabsi, T. Boubaker, R. Goumont
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Numerically optimized Markovian coupling and mixing in one-dimensional maps

, 2007
Algorithms are introduced that produce optimal Markovian couplings for large finite-state-space discrete-time Markov chains with sparse transition matrices; these algorithms are applied to some toy models motivated by fluid-dynamical mixing problems at ...
P, D, Jansons, KMM
core  

3D modeling of coupling between superconducting filaments via resistive matrix in AC magnetic field

, 2003
The ac loss of superconducting composite depends strongly on coupling between superconducting filaments via the resistive matrix. The established technique for loss reduction using twisted filaments relies on the decoupling of the filaments below a ...
Yang, Y., Cost, M., Martinez, E., Beduz, C., Vinot, E., Grilli, F., Costa Bouzo, M., Dutoit, B., Tixador, P.   +8 more
core   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Probing interactions through space using spin-spin coupling

, 2014
The work in this project was supported by the Engineering and Physical Sciences Research Council (EPSRC).The series of eight 5-(TeY)-6-(SePh)acenaphthenes (Y = Fp (2), Tol (3), An-p (4), An-o (5), Tp (6), Mes (7), Tip (8), Nap (9)) were prepared and ...
Woollins, J. Derek, Stanford, Martin W., Ashbrook, Sharon E., Knight, Fergus R., Camacho, Paula Sanz, Arachchige, Kasun S. Athukorala, Slawin, Alexandra M. Z., Buehl, Michael   +7 more
core   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Four-port coupled channel-guide device based on 2D photonic crystal structure [PDF]

, 2004
We have fabricated and measured a four-port coupled channel-waveguide device using W1 channel waveguides oriented along ΓK directions in a two-dimensional (2D) hole-based planar photonic crystal (PhC) based on silicon-on-insulator (SOI) waveguide ...
De La Rue, R M, Chong, H M H, Camargo, E A   +2 more
core   +1 more source