Results 71 to 80 of about 534,393 (266)

High-resolution NMR studies of solid halogenated organic compounds [PDF]

, 1995
This thesis is a study of solid halogenated organic compounds by Nuclear Magnetic Resonance Spectroscopy (NMR) in an attempt to extract previously inaccessible information.
Carss, Steven Andrew
core  

Optomechanical coupling between ultracold atoms and a membrane oscillator [PDF]

, 2014
In this thesis, I report on the realization of a hybrid optomechanical system in which ultracold atoms are coupled to a micromechanical membrane. The atoms are trapped in the intensity maxima of an optical standing wave formed by retroreflection of a ...
Korppi, Maria
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

SmB6 electron-phonon coupling constant from time- and angle-resolved photoelectron spectroscopy

, 2016
SmB6 is a mixed valence Kondo system resulting from the hybridization between localized f electrons and delocalized d electrons. We have investigated its out-of-equilibrium electron dynamics by means of time- and angle-resolved photoelectron spectroscopy.
Zacchigna M., Parmigiani F., Huang Y. K., Golden M. S., Cilento F., Crepaldi A., Frantzeskakis E., Van Heumen E., Manzoni G., Sterzi A.   +9 more
core   +1 more source

Spread-F/sporadic E coupling at Chung-Li, especially for postsunset periods of sunspot maximum years [PDF]

, 2003
Using ionogram-recorded data, the coupling between spread-F occurrence and enhanced E blanketing frequencies (fE) (indicative of fE changes), has been investigated for an equatorial-ionospheric-anomaly crest station, Chung-Li, for the postsunset periods ...
Bowman, G. G., Mortimer, I. K.
core   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

The effective field theory approach to the strong coupling issue in $f(T)$ gravity

, 2023
We investigate the scalar perturbations and the possible strong coupling issues of $f(T)$ around a cosmological background, applying the effective field theory (EFT) approach.
Wang, Bo, Zhao, Yaqi, Ren, Xin, Cai, Yi-Fu, Saridakis, Emmanuel N., Hu, Yu-Min   +5 more
core   +1 more source

Asymmetric Primaquine and Halogenaniline Fumardiamides as Novel Biologically Active Michael Acceptors

Molecules, 2018
Novel primaquine (PQ) and halogenaniline asymmetric fumardiamides 4a–f, potential Michael acceptors, and their reduced analogues succindiamides 5a–f were prepared by simple three-step reactions: coupling reaction between PQ and mono-ethyl ...
Zrinka Rajić, Maja Beus, Hana Michnová, Josipa Vlainić, Leentje Persoons, Ivan Kosalec, Josef Jampílek, Dominique Schols, Toma Keser, Branka Zorc   +9 more
doaj   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source