Results 71 to 80 of about 31,212,444 (222)

Dual pKa Lipid Nanoparticles for Lung‐tropic mRNA Delivery and pH‐Programmed Endosomal Escape

Advanced Science, EarlyView.
Lipid nanoparticles’ bottleneck lies in low endosomal escape efficiency and liver‐dominant delivery after intravenous administration. To overcome these limitations, we present a stepwise pH‐programmed lipid nanoparticle system enabled by our newly synthesized ionizable lipid.
Seong Gi Lim, Minju Lee, Yiming Wang, Eunjin Choi, Ji Sun Park, Kyungmin Park, Hayoung Jeon, Donghyun Kim, Donghyun Lee, Yeeun Lee, Kee‐Pyo Kim, Eunha Kim, Heebeom Koo   +12 more
wiley   +1 more source

E-cargo bikes as a personal transport mode in the UK: Insights from surveys and suburban trials

Journal of Cycling and Micromobility Research
This paper explores the potential of e-cargo bikes as a personal transport mode in the UK, reporting on a series of surveys and trials. Hypothesising that early adoption of this niche mode was geodemographically skewed, we carried out a nationally ...
Ian Philips, Sally Cairns, Alice De Séjournet, Jillian Anable, Labib Azzouz, Frauke Behrendt, Christian Brand, Noel Cass, Mary Darking, Clara Glachant, Eva Heinen, Nick Marks, Theresa Nelson   +12 more
doaj   +1 more source

Early Spatial and Contextual Coding Deficits in Hippocampal CA1 Precede Performance Decline in an Alzheimer's Disease Model

Advanced Science, EarlyView.
Two‐photon calcium imaging in behaving 5xFAD mice reveals early CA1 coding deficits before behavioral decline. Task‐related place cell activity and splitter cell trajectory coding are impaired, with reduced retrospective dominance and greater prospective weighting.
Yimei Li, Mary Ann Go, Hualong Zhang, Robertas Aleksynas, Juliana Kim, Mingyang Gao, Seigfred Prado, Magdalena Sastre, Simon R. Schultz   +8 more
wiley   +1 more source

A BSCB‐Penetrating Nanoplatform for Enhanced Luteolin Delivery in PRMT2‐Targeted Epigenetic Therapy of Spinal Cord Injury

Advanced Science, EarlyView.
In this work, MSN‐BO@LUT penetrates the blood‐spinal cord barrier for luteolin delivery in spinal cord injury. The nanodrug suppresses neuroinflammation and promotes functional recovery of the spinal cord. Mechanistically, luteolin targets protein arginine N‐methyltransferase (PRMT2) to decrease toll‐like receptor 4 (TLR4) methylation, thereby ...
Yixuan Wang, Bo Jin, Shipian Li, Qianxi Ouyang, Yu Xiao, Jiaxin Wen, Yehua Lai, Ping Wang, Yongjun Wang, Xuejun Cui, Weian Zhang, Min Yao   +11 more
wiley   +1 more source

Elektrofahrräder (E-Bikes)

, 2019
Hintergrund: Auf Grundlage der Auseinandersetzung mit der Thematik „Elektrofahrräder: Förderung körperlicher Aktivität versus Erhöhung des Verletzungsrisikos“ sind in der Diplomarbeit die Klärung und Erläuterung der für das Thema relevanten Begriffe zu ...
Saini, Susanne
core  

Similarity‐Enhanced Representation Learning of Non‐Canonical Amino Acids for Therapeutic Peptide Modeling

Advanced Science, EarlyView.
Non‐canonical amino acids (ncAAs) enhance peptide therapeutics but remain difficult to model computationally. SinCAA, a similarity‐enhanced pretraining framework, jointly optimizes contrastive learning guided by a novel conformational similarity metric with masked node reconstruction, capturing both functional relationships and chemical identity of ...
Chencheng Xu, Lesong Wei, Jianmin Wang, Yuanpeng Xiong, Ruochi Zhang, Yu Wang, Chao Zha, Qiangcheng Zeng, Xin Gao   +8 more
wiley   +1 more source

Multi-Objective Optimization of Off-Grid E-Bikes Charging Stations Powered by PhotoVoltaics

IEEE Access
The integration of renewable energy in the power supply chain of Electric Vehicles (EVs) is fundamental in order to decarbonize the transportation sector. Yet, this poses additional threats to the smooth functioning of power systems.
Fabio Corti, Gabriele Maria Lozito, Davide Astolfi, Salvatore Dello Iacono, Antony Vasile, Marco Pasetti, Alberto Reatti, Alessandra Flammini   +7 more
doaj   +1 more source

This is the cover of the fifth issue of "Flock of Bikes." Notice the bleed through on the scanned photocopy

, 2010
Figure 15. This is the cover of the fifth issue of "Flock of Bikes." Notice the bleed through on the scanned photocopy ( 21.5cm x 14cm ...
Miller, Joshua, Flock of Bikes
core  

Perceived risk of interaction with e-bikes

, 2023
E-bikes have gained global popularity due to their environmentally friendly and sustainable attributes, as well as their ability to provide fast speeds and power assistance.
Han, Lu (author)
core  

Molecular Glue Degraders Enhance CAPRIN1‐Dependent Lysosomal Degradation of APP and Reduce Amyloid β in Alzheimer's Disease

Advanced Science, EarlyView.
A new class of lysosome‐directed molecular glue degraders selectively enhance CAPRIN1–APP interactions, driving APP degradation and reducing amyloid‐β production in human neurons and Alzheimer's disease mouse models. This CAPRIN1‐dependent targeted protein degradation strategy reveals a previously unrecognized therapeutic approach for disrupting the ...
Sunghan Jung, Xu Wang, Bin Liu, Raktim Roy, Nancy Jaiswal, Ratan K. Rai, Yuichiro Takagi, Cen Gao, Lifan Zeng, Ho‐Yin Lo, Reagan K. Wohlford, Ryan K. Higgins, Bruce T. Lamb, Anantha Shekhar, Anita C. Bellail, Chunhai Hao   +15 more
wiley   +1 more source