Results 161 to 170 of about 23,390,793 (329)

Identification of mutations in laboratory-evolved microbes from next-generation sequencing data using breseq.

Methods in molecular biology, 2014
Daniel E. Deatherage, Jeffrey E. Barrick
semanticscholar   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Exponential Splines and Pseudo-Splines: Generation versus reproduction of exponential polynomials

, 2014
Subdivision schemes are iterative methods for the design of smooth curves and surfaces. Any linear subdivision scheme can be identified by a sequence of Laurent polynomials, also called subdivision symbols, which describe the linear rules determining ...
Conti, Costanza, Gemignani, Luca, Romani, Lucia   +2 more
core  

Sostenibilità, lingua e genere

, 2023
Questo articolo prende in esame la funzione svolta dal linguaggio per la costruzione della Gender Equality (‘parità di genere’), uno degli obiettivi della 2030 Agenda for Sustainable Development (‘Agenda 2030 per lo sviluppo Sostenibile’, d’ora in poi Agenda 2030), il “programma d’azione per le persone, il pianeta e la prosperità” promosso dall’ONU ...
openaire   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

E-generation, What’s New?

, 2011
This article discusses the "e-generation’s" characteristics and the management tools and methods capable of handling them. In particular, we take a look at how to get a better grip on this generation’s values when faced with the issues of being attractive, recruitment, and employee loyalty that many enterprises have to deal with.
Brillet, Franck, Hulin, Annabelle, Leroy, Julie, Bourliataux-Lajoinie, Stéphane   +3 more
openaire   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Development of a Second-Generation Antiandrogen for Treatment of Advanced Prostate Cancer

Science, 2009
C. Tran, Samedy Ouk, N. J. Clegg, Yu Chen, Philip A Watson, V. Arora, John Wongvipat, P. Smith-Jones, Dongwon Yoo, Andrew Kwon, Teresa Wasielewska, D. Welsbie, C. Chen, C. Higano, T. Beer, D. Hung, H. Scher, M. Jung, C. Sawyers   +18 more
semanticscholar   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

CONSIDERAÇÕES SOBRE SERVIÇOS DE ADVOCACY 1 PARA PESSOAS IDOSAS NO CONTEXTO DE REVITALIZAÇÃO URBANA

Kairós Gerontologia, 2010
1. A tradução optou por manter o termo “advocacy” no original, uma vez que é um tipo de serviço inexistente no Brasil (N. do T.). Este artigo é baseado em uma recente pesquisa para a avaliação de um serviço de advocacy voltado para pessoas idosas, o ...
Eileen Fairhurst, Ilana Mountian, Judith Sixsmith   +2 more
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