Results 181 to 190 of about 1,919,291 (265)

Transcriptional and Epigenetic Plasticity Drive an Alternative Non-clonal Mechanism of Resistance to <i>Kras</i> ^G12D Inhibition in Pancreatic Cancer. [PDF]

Cancer Commun (Lond)
Caggiano A, Agostini A, Iacuone D, Priori L, Esposito A, Ceccarelli A, Rosa D, Pasini D, Ugel S, De Sanctis F, Cinti F, Sette C, Vinciguerra GLR, Dezi C, Bronte V, Piro G, Corbo V, Tortora G, Carbone C.   +18 more
europepmc   +1 more source

Edutainment e Genere

, 2011
openaire   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Hot exciton dissociation in graphene nanoribbons. [PDF]

Nat Commun
Wen G, Xu F, Tries A, Zheng W, Virgilio LD, Fu S, Chen X, Yang L, Xiao Z, Kläui M, Osella S, Ma J, Wang X, Feng X, Mai Y, Bonn M, Wang HI.   +16 more
europepmc   +1 more source

Sesso e genere nell’identità della persona

, 2016
openaire   +4 more sources

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Evolutionary trends and genetic determinants of third-generation cephalosporin resistance in <i>Escherichia coli</i> from Korean livestock: a 14-year longitudinal study, 2010-2023. [PDF]

Front Microbiol
Kim JI, Choi JH, Ali MS, Moon BY, Kang HS, Kim HY, Hwang YJ, Lee YH, Kim MY, Kim JM, Unno T, Lim SK.   +11 more
europepmc   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Controls on natural hydrogen generation during serpentinization of mantle rocks. [PDF]

Nat Commun
Christiansen R, Sobh M, Ostertag-Henning C, Gianni G, Saspiturry N, Chevrot S, Langenheim V, García-Pintado J, Gabriel G.   +8 more
europepmc   +1 more source