Results 171 to 180 of about 23,390,793 (329)
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...Eloise Mastrangelo, Flavio Di Pisawiley +1 more sourceβ‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Molecular Oncology, EarlyView.Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón +8 morewiley +1 more sourceNicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling
Molecular Oncology, EarlyView.AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu +5 morewiley +1 more sourcePARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer
Molecular Oncology, EarlyView.PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer +21 morewiley +1 more sourceCharacterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer
Molecular Oncology, EarlyView.This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane +9 morewiley +1 more sourceRole of Bradykinin in Anaphylactoid Reactions during Hemodialysis with AN69 Dialyzers [PDF]
, 1993 Barkhausen, Regina, Fink, Edwin, Heidland, August, Kulzer, Peter, Schaefer, Liliana, Schaefer, Roland M. +5 morecore +1 more sourceBridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology
Molecular Oncology, EarlyView.Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme +8 morewiley +1 more sourceExploring the Sensitivity of Next Generation Gravitational Wave Detectors
, 2016 B. Abbott, R. Abbott, T. Abbott, M. Abernathy, K. Ackley, C. Adams, P. Addesso, R. Adhikari, V. Adya, C. Affeldt, N. Aggarwal, O. Aguiar, A. Ain, P. Ajith, B. Allen, P. Altin, S. Anderson, W. Anderson, K. Arai, M. Araya, C. Arceneaux, J. Areeda, K. Arun, G. Ashton, M. Ast, S. Aston, P. Aufmuth, C. Aulbert, S. Babak, P. Baker, S. Ballmer, J. Barayoga, S. Barclay, B. Barish, D. Barker, B. Barr, L. Barsotti, J. Bartlett, I. Bartos, R. Bassiri, J. Batch, C. Baune, A. Bell, B. Berger, G. Bergmann, C. Berry, J. Betzwieser, S. Bhagwat, R. Bhandare, I. Bilenko, G. Billingsley, J. Birch, R. Birney, S. Biscans, A. Bisht, C. Biwer, J. Blackburn, C. Blair, D. Blair, R. Blair, O. Bock, C. Bogan, A. Bohé, C. Bond, R. Bork, S. Bose, P. Brady, V. Braginsky, J. Brau, M. Brinkmann, P. Brockill, J. Broida, A. Brooks, D. Brown, D. Brown, N. Brown, S. Brunett, C. Buchanan, A. Buikema, A. Buonanno, R. Byer, M. Cabero, L. Cadonati, C. Cahillane, J. C. Bustillo, T. Callister, J. Camp, K. Cannon, J. Cao, C. Capano, S. Caride, S. Caudill, M. Cavaglià, C. Cepeda, S. Chamberlin, M. Chan, S. Chao, P. Charlton, B. Cheeseboro, H. Chen, Y. Chen, C. Cheng, H. Cho, M. Cho, J. Chow, N. Christensen, Q. Chu, S. Chung, G. Ciani, F. Clara, J. Clark, C. Collette, L. Cominsky, M. Constancio, D. Cook, T. Corbitt, N. Cornish, A. Corsi, C. Costa, M. Coughlin, S. Coughlin, S. Countryman, P. Couvares, E. Cowan, D. Coward, M. Cowart, D. Coyne, R. Coyne, K. Craig, J. Creighton, J. Cripe, S. Crowder, A. Cumming, L. Cunningham, T. D. Canton, S. L. Danilishin, K. Danzmann, N. Darman, A. Dasgupta, C. F. S. Costa, I. Dave, G. Davies, E. Daw, S. De, D. DeBra, W. D. Pozzo, T. Denker, T. Dent, V. Dergachev, R. Derosa, R. DeSalvo, R. Devine, S. Dhurandhar, M. D'iaz, I. Palma, F. Donovan, K. Dooley, S. Doravari, R. Douglas, T. Downes, M. Drago, R. Drever, J. Driggers, S. Dwyer, T. Edo, M. Edwards, A. Effler, H. Eggenstein, P. Ehrens, J. Eichholz, S. Eikenberry, W. Engels, R. Essick, T. Etzel, M. Evans, T. Evans, R. Everett, M. Factourovich, H. Fair, S. Fairhurst, X. Fan, Q. Fang, B. Farr, W. Farr, Marc Favata, M. Fays, H. Fehrmann, M. Fejer, E. Fenyvesi, E. Ferreira, R. Fisher, M. Fletcher, Z. Frei, A. Freise, R. Frey, P. Fritschel, V. Frolov, P. Fulda, M. Fyffe, H. Gabbard, J. Gair, S. Gaonkar, G. Gaur, N. Gehrels, P. Geng, J. George, L. Gergely, A. Ghosh, A. Ghosh, J. Giaime, K. Giardina, K. Gill, A. Glaefke, E. Goetz, R. Goetz, L. Gondán, G. Gonz'alez, A. Gopakumar, N. Gordon, M. Gorodetsky, S. Gossan, C. Graef, P. Graff, A. Grant, S. Gras, C. Gray, A. Green, H. Grote, S. Grunewald, X. Guo, A. Gupta, M. Gupta, K. Gushwa, E. Gustafson, R. Gustafson, J. Hacker, B. Hall, E. Hall, G. Hammond, M. Haney, M. Hanke, J. Hanks, C. Hanna, M. Hannam, J. Hanson, T. Hardwick, G. Harry, I. Harry, M. Hart, M. Hartman, C. Haster, K. Haughian, M. Heintze, M. Hendry, I. Heng, J. Hennig, J. Henry, A. Heptonstall, M. Heurs, S. Hild, D. Hoak, K. Holt, D. Holz, P. Hopkins, J. Hough, E. Houston, E. Howell, Y. Hu, S. Huang, E. Huerta, B. Hughey, S. Husa, S. Huttner, T. Huynh--Dinh, N. Indik, D. Ingram, R. Inta, H. N. Isa, M. Isi, T. Isogai, B. Iyer, K. Izumi, H. Jang, K. Jani, S. Jawahar, L. Jian, F. Jim'enez-Forteza, W. Johnson, D. Jones, R. Jones, L. Ju, K. Haris, C. Kalaghatgi, V. Kalogera, S. Kandhasamy, G. Kang, J. Kanner, S. Kapadia, S. Karki, K. Karvinen, M. Kasprzack, E. Katsavounidis, W. Katzman, S. Kaufer, T. Kaur, K. Kawabe, M. Kehl, D. Keitel, D. Kelley, W. Kells, R. Kennedy, J. Key, F. Khalili, S. Khan, Z. Khan, E. Khazanov, N. Kijbunchoo, Chi-Woong Kim, Chunglee Kim, J. Kim, K. Kim, N. Kim, W. Kim, Y.-M. Kim, S. Kimbrell, E. King, P. King, J. Kissel, B. Klein, L. Kleybolte, S. Klimenko, S. Koehlenbeck, V. Kondrashov, A. Kontos, M. Korobko, W. Korth, D. Kozak, V. Kringel, C. Krueger, G. Kuehn, P. Kumar, R. Kumar, L. Kuo, B. Lackey, M. Landry, J. Lange, B. Lantz, P. Lasky, M. Laxen, A. Lazzarini, S. Leavey, E. Lebigot, C. Lee, H. Lee, H. Lee, K. Lee, A. Lenon, J. Leong, Y. Levin, J. Lewis, T. G. F. Li, A. Libson, T. Littenberg, N. Lockerbie, A. Lombardi, L. London, J. Lord, M. Lormand, J. Lough, H. Luck, A. Lundgren, R. Lynch, Y. Ma, B. Machenschalk, M. MacInnis, D. Macleod, F. Magaña-Sandoval, L. M. Zertuche, R. Magee, V. Mandic, V. Mangano, G. Mansell, M. Manske, S. M'arka, Z. M'arka, A. Markosyan, E. Maros, I. Martin, D. Martynov, K. Mason, T. Massinger, M. Masso-Reid, F. Matichard, L. Matone, N. Mavalvala, N. Mazumder, R. McCarthy, D. McClelland, S. Mccormick, S. Mcguire, G. Mcintyre, J. McIver, D. McManus, T. McRae, S. McWilliams, D. Meacher, G. Meadors, A. Melatos, G. Mendell, R. Mercer, E. Merilh, S. Meshkov, C. Messenger, C. Messick, P. Meyers, H. Miao, H. Middleton, E. Mikhailov, A. Miller, A. Miller, B. Miller, J. Miller, M. Millhouse, J. Ming, S. Mirshekari, C. Mishra, S. Mitra, V. Mitrofanov, G. Mitselmakher, R. Mittleman, S. Mohapatra, B. Moore, C. Moore, D. Moraru, G. Moreno, S. Morriss, K. Mossavi, C. Mow-Lowry, G. Mueller, A. Muir, A. Mukherjee, D. Mukherjee, S. Mukherjee, N. Mukund, A. Mullavey, J. Munch, D. Murphy, P. Murray, A. Mytidis, R. Nayak, K. Nedkova, T. Nelson, A. Neunzert, G. Newton, T. Nguyen, A. Nielsen, A. Nitz, D. Nolting, M. Normandin, L. Nuttall, J. Oberling, E. Ochsner, J. O'Dell, E. Oelker, G. Ogin, J. Oh, S. Oh, F. Ohme, M. Oliver, P. Oppermann, R. Oram, B. O’Reilly, R. O’Shaughnessy, D. Ottaway, H. Overmier, B. Owen, A. Pai, S. Pai, J. R. Palamos, O. Palashov, A. Pal-Singh, H. Pan, C. Pankow, F. Pannarale, B. Pant, M. Papa, H. Paris, W. Parker, D. Pascucci, Z. Patrick, B. Pearlstone, M. Pedraza, L. Pekowsky, A. Pele, S. Penn, A. Perreca, L. Perri, M. Phelps, V. Pierro, I. Pinto +499 moresemanticscholar +1 more source
