Results 121 to 130 of about 111,419 (313)

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

open access: yesFEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman   +2 more
wiley   +1 more source

E-KNOWLEDGE FOR SUPPORTING STRATEGIC DECISION MAKING PROCESS AT REGIONAL LEVEL [PDF]

open access: yes
The paper approaches a subject of great novelty in knowledge-based society related to regional strategic decision making. This work and the innovative solutions introduced represent the results of a Romanian research project: “Regional Knowledge ...
Emilia GOGU, Mihaela MUREªAN
core  

Cell wall target fragment discovery using a low‐cost, minimal fragment library

open access: yesFEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan   +5 more
wiley   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

Post Mortem Privacy

open access: yesSCRIPTed: A Journal of Law, Technology & Society, 2013
Lilian Edwards
doaj   +1 more source

Digital Transformation of Civil Registration System in Cameroon: Innovations in e-Governance

open access: yesJournal of Digital Technologies and Law
Objective: to study the innovative transformations in the field of e-Governance introduced into Cameroon’s civil registration system during the 2024 legislative reforms.
R. K. Ndiyun, R. M. Mukonza
doaj   +1 more source

ANALYSIS OF FACTORS AFFECTING ON E-GOVERNANCE AND DEVELOPMENT OF A COGNITIVE MODEL OF ITS DEVELOPMENT

open access: hybrid, 2022
Mzia Kiknadze   +3 more
openalex   +2 more sources

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