Results 171 to 180 of about 22,194,023 (315)

From E-government to E-governance in Europe

open access: yes, 2012
The influence of e-government on the modernization and growth of public sector initiatives in Europe have been deeply claimed. Little is known, however, about how the recent so called shift from e-government to e-governance takes place in European ...
PADOVANI, EMANUELE   +2 more
core  

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

open access: yesMolecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

open access: yesMolecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner   +14 more
wiley   +1 more source

Governance e partecipazione politica. Teorie e ricerche sociologiche

open access: yes, 2012
Pur essendo i concetti di governance e partecipazione politica fra loro distinti, i significati loro rispettivamente attribuiti e l’uso che ne viene fatto, sia in campo scientifico, sia nelle arene politiche e sociali, evidenziano tanto potenzialita ...
D'Albergo, Ernesto   +2 more
core  

The development and evolution of the Irish Hip Fracture Database: a quality care initiative 2013-2024. [PDF]

open access: yesArch Osteoporos
Brent L   +9 more
europepmc   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

open access: yesMolecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena   +15 more
wiley   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

open access: yesMolecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen   +9 more
wiley   +1 more source

Artificial Intelligence Governance in Health Systems: Systematic Review of Frameworks and Integrative Model Proposal. [PDF]

open access: yesJ Med Internet Res
Alami H   +10 more
europepmc   +1 more source

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