Results 81 to 90 of about 22,194,023 (315)

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

open access: yesFEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes   +3 more
wiley   +1 more source

E-governance for small and medium enterprises

open access: yes, 2007
Computing, Information Technology and Web-based Technology have become an integral part of the modern day society. They have brought about a revolution in the way different human endeavours are undertaken.
Godara, Varuna, Agrawal, Rakesh
core  

Global governance by goal-setting: the novel approach of the UN Sustainable Development Goals: Open issue, part II

open access: yes, 2017
The 17 Sustainable Development Goals (SDGs) of the United Nations present a novel approach to global governance where goal-setting features as a key strategy.
Global Sustainability Governance   +4 more
core   +1 more source

E-Participation in the Context of Democracy Concept Transformation

open access: yesУправленческое консультирование, 2018
The paper is devoted to the study of «electronic participation» as a special form of social and political participation of citizens in public affairs.
Andrei Vladimirovich Chugunov
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

open access: yesFEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe   +3 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Tabling sustainable commodities through private governance

open access: yes, 2013
Over the past few decades, new types of private governance arrangements arose which increasingly shape outcomes in global governance. The object of this dissertation is a specific form of private governance arrangement which emerged in the early 2000s in
Environmental Governance   +2 more
core  

The impact of e-governance on shortening the public service delivery terms

open access: yesTelos: Revista de Estudios Interdisciplinarios en Ciencias Sociales
The impact issue and development of e-governance on shortening the terms of public service provision is urgent for ensuring the efficiency of government agencies. The public service delivery terms affect the effectiveness of the state's public policy and
Oleh Lazor   +5 more
doaj   +1 more source

Problems of providing information security in the system of public administration

open access: yesAspekti Publìčnogo Upravlìnnâ, 2018
The article analyzes the scientific approaches to the problem of providing information security of the public administration system. It was determined that information security in the system of public administration is an integral part of the national ...
Y. I. Chmyr
doaj   +1 more source

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