Results 91 to 100 of about 96,753 (265)
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Хабаршы Журналистика сериясы, 2016 This article analyses the changing policy content in dealing with re-ligious topics in the cyberspace using an example of Kazakhstan. First, it looks at the current trends in the new media and changing nature of the Internet services and discourses ...
R. Abazov
doaj
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
e-Government, e-Governance, e-Democracy
, 2002 The goal of state administration operating on the principles of e-government is to help all the clients and partners of any public sector institution to take part in business processes of state administration via Internet. Representatives of state institutions, their clients and partners thus form a virtual society that shares in the knowledge ...
openaire +2 more sources
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Frontiers in Sustainable CitiesIntegrating AI and blockchain technologies holds significant potential for enhancing e-governance, particularly in improving predictive policy execution within smart cities. This study conducts a comprehensive review and bibliometric analysis of existing
Sandi Lubis +6 more
doaj +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Estonia’s digital transformation: a blueprint for e-governance and global leadership in innovation [PDF]
Ante PortasExamining Estonia’s ascent as a global leader in e-governance, the document highlights its integration of digital technologies into public administration to enhance transparency, efficiency, and accessibility.
Ivanna Makuch-Fedorkova, Yurii Hordei
doaj
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Electronic Administration Styles and Their Determinants. Evidence from Spanish Local Governments
Transylvanian Review of Administrative Sciences, 2014 This paper analyzes the factors underlying the development of e-government, as an overall process, as well as of each of the three stages identified in the prior literature (e-government, egovernance and e-democracy).
José Valeriano FRÍAS-ACEITUNO +2 more
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