Results 91 to 100 of about 22,194,023 (315)

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Assisting Coastal and Marine Governance: Enhancing Decision Support Through Digital Tools for Cumulative Impact Assessment

Ocean and Society
Coastal regions are increasingly pressured by diverse human activities, leading to cumulative effects that undermine ecosystem integrity and functioning, including disruptions to biodiversity, habitat degradation, and alterations of ecological processes.
Jonne Kotta, Jean-Marc Douguet, Elis Vollmer, Mihhail Fetissov, Elisa Furlan, Gea Grassi, Federica Zennaro, Hector Charles Pagan, Helen Orav-Kotta   +8 more
doaj   +1 more source

Evaluation of digital development of administrative and territorial units of Dnipropetrovsk region

Aspekti Publìčnogo Upravlìnnâ, 2019
The article presents and analyzes the results of the May 2019 study of the digital development of districts, cities and territorial communities of Dnipropetrovsk region. It is through such research that we can identify critical territories, local digital
Sergiy Kvitka, Oleksandr Tytarenkо, Oleksandr Mazur   +2 more
doaj   +1 more source

GLASS: A Citizen-Centric Distributed Data-Sharing Model within an e-Governance Architecture. [PDF]

Sensors (Basel), 2022
Lo O, Buchanan WJ, Sayeed S, Papadopoulos P, Pitropakis N, Chrysoulas C.   +5 more
europepmc   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Digital model for monitoring national programs: the Kazakhstan experience

Frontiers in Artificial Intelligence
This paper presents a conceptual digital model for monitoring national programs designed to enhance their effectiveness, transparency, and performance in the context of digital transformation in public administration.
Mafura Uandykova, Tolkyn Mirkassimova, Gulnar Mukhamejanova, Assel Yeleukulova, Akhmed Baikhojayev, Gulnar Astaubayeva   +5 more
doaj   +1 more source

The Role of E-Governance in Combating COVID-19 and Promoting Sustainable Development: A Comparative Study of China and Pakistan. [PDF]

Chin Polit Sci Rev, 2021
Ullah A, Pinglu C, Ullah S, Abbas HSM, Khan S.   +4 more
europepmc   +1 more source

Semantic frameworks for e-government

Proceedings of the 1st international conference on Theory and practice of electronic governance, 2007
This paper explains how semantic frameworks can be used to support successful e-Government initiatives by connecting system design to a shared understanding of interactions and processes. It shows how metadata standards and repositories can be used to establish and maintain such an understanding, and how they can be used in the automatic generation and
Charles Crichton, Jim Davies, Jeremy Gibbons, Steve Harris, Aadya Shukla   +4 more
openaire   +3 more sources

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source