Results 61 to 70 of about 457 (204)

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis

FEBS Letters, EarlyView.
This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng, Shen‐Shin Chang, Feng‐Wei Chen, Ying‐Chieh Su, Thanh Phuong Nguyen, Yu‐Wei Hsiao, Jhih‐Ying Chi, Hsin‐Yin Liang, Ju‐Ming Wang   +8 more
wiley   +1 more source

DIGITAL COMPETITIVENESS INDICATORS AND THE E-GOVERNMENT PROCESS IN ROMANIA

Journal of Smart Economic Growth, 2018
The article showcases the results in Romania for the following indicators: Digital Economy and Society Index (EU28 DESI) defined for the countries in the European Union, International Digital Economy and Society Index (I-DESI), an extension of the UE28 ...
Dorin Lixăndroiu
doaj  

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

Analysis of Digital Gaps in the Development of E- government across Africa: A Comparative Study of Performance and Influencing Factors According to EGDI (2020-2022).

مجلة العلوم و آفاق المعارف
This study aims to analyse the digital gaps in the development of e-government across African countries during the period 2020-2022, with a focus on factors that influence performance according to E-government Development Index (EGDI).
Omar Mihoubi, Brahim Sebiat
doaj   +1 more source

Mapping Publication Trend of E-Government Development Index (Social Science Discipline Analysis)

Jurnal Ilmiah Peuradeun
This study aims to determine the research development with the Theme E-Government Development Index (EGDI) from 2003-2023. The method used in this study is qualitative with literature study. This research data source uses the Scopus database to identify research themes related to the EGDI for the 2003-2023 period, with a total of 240 article documents ...
Sukarno, Mohamad, Mutiarin, Dyah
openaire   +2 more sources

Comparing the paths of Hedgehog release in artificial and natural settings

FEBS Letters, EarlyView.
Hh morphogens require solubilization factors to overcome their tight association with the plasma membrane and signal to distant cells, but the precise functions of these factors are controversial. Here, we use published in vivo observations as the most relevant evidence to test their suggested functions and discuss contradictions and gaps between in ...
Janna Puschmann, Kay Grobe
wiley   +1 more source

ANALITICAL ESTIMATION OF ELECTRONIC GOVERNMENT DEVELOPMENT IN THE RUSSIAN REGIONS BASING ON SYSTEMIC-FUNCTIONAL APPROACH

Russian Journal of Economics and Law, 2014
Objective: to define the methodological approach to the analysis of e-government development in the Russian regions. Methods: systematic approach, the method of analytical assessment, methods of comparative, descriptive, structural-functional analysis ...
A. S. Borisova
doaj  

Mitochondrial translation and coordinated cytosolic translation in metabolic homeostasis and disease

FEBS Letters, EarlyView.
Mitochondrial function depends on coordinated protein production from the nuclear and mitochondrial genomes. This review highlights how cytosolic and mitochondrial translation, mRNA localization, protein import, and respiratory complex assembly are integrated to maintain mitochondrial proteostasis and function.
Boseon Kim, Thi Thanh Mai Tran, Nakyung Kang, Min‐Woo Lee, Mihye Lee   +4 more
wiley   +1 more source

E-government and public investment management under fiscal consolidation [PDF]

Public and Municipal Finance
Type of the article: Research Article AbstractThe study tests whether e-government development is associated with the level of central-government investment and the size of the investment cut that accompanies fiscal consolidation.
Mkhitar Aslanyan, Liudmyla Zakharkina, Rostyslav Shchokin, Tetiana Shabelnyk, Zaiga Oborenko, Diana Zmicerevska, Zanna Klescevņikova   +6 more
doaj   +1 more source