Results 81 to 90 of about 256,902 (295)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

ANALITICAL ESTIMATION OF ELECTRONIC GOVERNMENT DEVELOPMENT IN THE RUSSIAN REGIONS BASING ON SYSTEMIC-FUNCTIONAL APPROACH

open access: yesRussian Journal of Economics and Law, 2014
Objective: to define the methodological approach to the analysis of e-government development in the Russian regions. Methods: systematic approach, the method of analytical assessment, methods of comparative, descriptive, structural-functional analysis ...
A. S. Borisova
doaj  

Analysis of Digital Gaps in the Development of E- government across Africa: A Comparative Study of Performance and Influencing Factors According to EGDI (2020-2022).

open access: yesمجلة العلوم و آفاق المعارف
This study aims to analyse the digital gaps in the development of e-government across African countries during the period 2020-2022, with a focus on factors that influence performance according to E-government Development Index (EGDI).
Omar Mihoubi, Brahim Sebiat
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

open access: yesMolecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen   +11 more
wiley   +1 more source

An Efficiency Measurement of E-Government Performance for United Nation Ranking Index

open access: yes, 2017
In order to serve the society in an electronic manner, many developing countries have launched tremendous e-government projects. The strategies of development and implementation e-government system have reached different levels, and to ensure consistency
Lin Jie, Yassine Jadi
core   +1 more source

DIGITAL COMPETITIVENESS INDICATORS AND THE E-GOVERNMENT PROCESS IN ROMANIA

open access: yesJournal of Smart Economic Growth, 2018
The article showcases the results in Romania for the following indicators: Digital Economy and Society Index (EU28 DESI) defined for the countries in the European Union, International Digital Economy and Society Index (I-DESI), an extension of the UE28 ...
Dorin Lixăndroiu
doaj  

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

E-government systems success and user acceptance in developing countries: The role of perceived support quality [PDF]

open access: yes, 2013
This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.Electronic government (e-Government) projects create numerous benefits and opportunities for both governments and citizens worldwide.
AlKhatib, Hala
core  

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

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