Results 71 to 80 of about 47,622,148 (289)

E-government Challenges in Developing Countries: Development of Iraqi E-government

, 2023
E-government involves utilizing technology to provide information and deliver governmental services to employees, citizens, and businesses. Developing countries implementing e-government should aim to keep pace with rapid technological advances ...
ahmed totonchi (12221303)
core   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

The impact of e-governance on shortening the public service delivery terms

Telos: Revista de Estudios Interdisciplinarios en Ciencias Sociales
The impact issue and development of e-governance on shortening the terms of public service provision is urgent for ensuring the efficiency of government agencies. The public service delivery terms affect the effectiveness of the state's public policy and
Oleh Lazor, Oksana Lazor, Iryna Yunyk, Ivan Zubar, Maryna Dzeveliuk, Andrii Dzeveliuk   +5 more
doaj   +1 more source

COMPARATIVE ANALYSIS OF THE E-GOVERNMENT DEVELOPMENT INDEX: A CASE STUDY OF SINGAPORE AND AFGHANISTAN

Sosiohumaniora
This study analyzes the differences in the development of e-government in Singapore and Afghanistan using the E-Government Development Index (EGDI) indicators which include the Online Services Index (OSI), Human Capital Index (HCI), and Telecommunication Infrastructure Index (TII).
Sukma Aditya Ramadhan, Eko Priyo Purnomo
openaire   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Assessing the impact of institutional environment quality on the development of e-commerce in developed and developing countries [PDF]

Problems and Perspectives in Management
This study uses the new institutional economic theory and demonstrates how the quality of the institutional environment can be correlated with the development of e-commerce in different countries.
Aksaule Zhanbozova, Tolkyn Azatbek, Marat Myrzakhmet   +2 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Analysis of Digital Gaps in the Development of E- government across Africa: A Comparative Study of Performance and Influencing Factors According to EGDI (2020-2022).

مجلة العلوم و آفاق المعارف
This study aims to analyse the digital gaps in the development of e-government across African countries during the period 2020-2022, with a focus on factors that influence performance according to E-government Development Index (EGDI).
Omar Mihoubi, Brahim Sebiat
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source