Results 91 to 100 of about 256,902 (295)

Examining the global influence of e-governance on corruption: a panel data analysis

Future Business Journal
This study analyzes the impact of e-governance on corruption using a panel dataset comprising 110 countries over the period from 2003 to 2021. The specific focus of the research is on the relationship between the E-government Development Index (EGDI) and
Dina Ali Seiam, Doaa Salman
doaj   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Development index and the challenges of adopting artificial intelligence in improving the quality of e-government services to citizens in Jordan

Problems of Information Society
The purpose of this study is to evaluate the global and continental positions of e-government models in countries such as Jordan by analysing their experiences. The evaluation of the progress of e-government is carried out using a multi-practice methodology, which incorporates a variety of different procedures and techniques.
Mohammad Ali ALQudah, Leyla Muradkhanli
openaire   +2 more sources

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

DIGITAL TRANSFORMATION OF PUBLIC ADMINISTRATION: PROACTIVE CUSTOMER SUPPORT

Хабаршысы. Экономика сериясы, 2019
The article considers the issue of digital transformation, which can become the basis for the further development of the principle of management by results of the state, since it allows you to overcome its previously identified limitations.
S.T. Ziyadin, A. Shaikh, G.Zh. Ismail
doaj   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

E-government initiatives in Bhutan: Government to Citizen(G2C) service delivery initiative - A case study

, 2012
Since the second half of 20th century the world has witnessed unprecedented waves of public sector reforms that are global in nature and scope (Miller 2005); this is commonly referred to as New Public Management (NPM) (Hood 1991; Tolofari 2005; Atreya ...
Dorji, Sithar
core  

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Information and Communication Technology (ICT) and Economic Growth Nexus: A Comparative Global Analysis [PDF]

Pakistan Journal of Commerce and Social Sciences, 2018
This paper analyzes the impact of diverse ICT indicators on economic growth at both global and regional levels. The analysis is based on a sample of 149 counties over the period 1980-2015. The empirical exercise is based on Ordinary Least Squares (OLS),
Muhammad Tariq Majeed, Tayba Ayub
doaj  

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source