Results 111 to 120 of about 47,622,148 (289)

The Role of Administrative Digitalization and Economic Development in Shaping Fiscal Efficiency: A Cross-National Analysis [PDF]

open access: yesOvidius University Annals: Economic Sciences Series
The paper investigates the relationship between government digitalization and economic and fiscal performance in European countries. Two multiple regressions were used with GDP(Gross Domestic Product) per capita and Tax Revenue as Percentage of GDP ...
Lăcrămioara Mansour   +2 more
doaj  

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola   +11 more
wiley   +1 more source

Study on Comprehensive Evaluation Index System for Education E-government Performance of College and University

open access: yesMATEC Web of Conferences, 2016
First, it sets forth the connotation of education E-government performance evaluation in college and university, Then it illustrates its design principles as directive, complete, scientific, feasible, and development.
Ye Lijuan, Yu Fang, Zhong Jiaming
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

open access: yesMolecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim   +3 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

open access: yesMolecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq   +8 more
wiley   +1 more source

Analysis of Latvian E-government Effectiveness

open access: yes
This research focuses on e-government development index. To raise the index in Latvia, factors influencing the index value were studied and recommendations for increasing the e-government development index are offered.The influencing factors significance
Dumpe, Daiga, Arhipova, Irina
core  

E-Government Partnerships Across Levels of Government [PDF]

open access: yes
E-government Partnerships across Levels of Government, is an overview of the challenges and approaches to creating a collaborative and cooperative partnership across levels of government for e-government development and implementation.E-Governance ...
Michalun, Varinia, Charbit, Claire
core  

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

open access: yesMolecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park   +6 more
wiley   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

open access: yesMolecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang   +9 more
wiley   +1 more source

E-Government Development: Catalysing Agile Governance Transformation in Indonesia

open access: yesJournal of Contemporary Governance and Public Policy
E-government is considered a crucial instrument for service transformation as it is believed to assist in achieving the government’s objectives by functioning as a flexible digital service platform for development.
Dyah Mutiarin   +3 more
doaj   +1 more source

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