Results 111 to 120 of about 256,902 (295)

Assessment of the results of the functioning of E-Government and digitalization of public services

Интеллект. Инновации. Инвестиции
The digital transformation of the modern economy consists of the introduction of end-to-end digital technologies in all spheres of life in modern society and in the public administration sector.
I. S. Kalganov
doaj   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

The Role of Administrative Digitalization and Economic Development in Shaping Fiscal Efficiency: A Cross-National Analysis [PDF]

Ovidius University Annals: Economic Sciences Series
The paper investigates the relationship between government digitalization and economic and fiscal performance in European countries. Two multiple regressions were used with GDP(Gross Domestic Product) per capita and Tax Revenue as Percentage of GDP ...
Lăcrămioara Mansour, Elena Cerasela Spătariu, Raluca Andreea Trandafir   +2 more
doaj  

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

E-Government Development: Catalysing Agile Governance Transformation in Indonesia

Journal of Contemporary Governance and Public Policy
E-government is considered a crucial instrument for service transformation as it is believed to assist in achieving the government’s objectives by functioning as a flexible digital service platform for development.
Dyah Mutiarin, Nur Khaerah, Andi Visca Irfa Nyssa, Nasrulhaq Nasrulhaq   +3 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

The Relationship between Transparency and E-Government: An Empirical Support

, 2013
E-government requires more attention from researchers to investigate the factors that predict the success of such initiative. This study used secondary data from international reports to investigate the relationship between transparency and e-government ...
Abu-Shanab, Emad A.
core  

E-Government Service for Driving Digital Creative Economy in Developing Region: Perspective of Technology Readiness Index and PLS-SEM

Applied Information System and Management (AISM)
E-government plays an important role in digital economic transformation by improving access to public services and driving economic growth. One implementation in West Papua Province is Rumahekraf, a digital marketing platform for creative economy players in the local region. However, the adoption of this platform is still low, and not many studies have
Nanes Fitri Rahmawati, Dedi I. Inan, Ratna Juita, Muhamad Indra   +3 more
openaire   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source