Results 101 to 110 of about 1,452,109 (316)

A new perspective on the competitiveness of nations [PDF]

, 2008
The capability of firms to survive and to have a competitive advantage in global markets depends on, amongst other things, the efficiency of public institutions, the excellence of educational, health and communications infrastructures, as well as on the ...
Artto, Blanke, Boznar, Charnes, Emel Aktaş, Füsun Ülengin, Gündüz Ulusoy, Hair, Hruschka, Hwarng, Karnani, Kohonen, Li, Mangiameli, McArthur, Milligan, Nour, Onsel Sahin, Oral, Oral, Oral, Oral, Oral, Oral, Oral, Porter, Porter, Sala-i-Martin, Swanson, Ulengin, Y. İlker Topcu, Yoon, Zanakis, Özgür Kabak, Şule Önsel   +34 more
core   +2 more sources

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

ANALITICAL ESTIMATION OF ELECTRONIC GOVERNMENT DEVELOPMENT IN THE RUSSIAN REGIONS BASING ON SYSTEMIC-FUNCTIONAL APPROACH

Russian Journal of Economics and Law, 2014
Objective: to define the methodological approach to the analysis of e-government development in the Russian regions. Methods: systematic approach, the method of analytical assessment, methods of comparative, descriptive, structural-functional analysis ...
A. S. Borisova
doaj  

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Examining the global influence of e-governance on corruption: a panel data analysis

Future Business Journal
This study analyzes the impact of e-governance on corruption using a panel dataset comprising 110 countries over the period from 2003 to 2021. The specific focus of the research is on the relationship between the E-government Development Index (EGDI) and
Dina Ali Seiam, Doaa Salman
doaj   +1 more source

Azormod dynamic general equilibrium model for Azores [PDF]

, 2009
The main objective of this paper is to present a multi-sectoral, multi-regional dynamic modelling platform of the Azores economy integrated within the European and global context.
Bayar, Ali, Fortuna, Mário, Mohora, Cristina, Opese, Masudi, Sisik, Suat   +4 more
core  

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

DIGITAL COMPETITIVENESS INDICATORS AND THE E-GOVERNMENT PROCESS IN ROMANIA

Journal of Smart Economic Growth, 2018
The article showcases the results in Romania for the following indicators: Digital Economy and Society Index (EU28 DESI) defined for the countries in the European Union, International Digital Economy and Society Index (I-DESI), an extension of the UE28 ...
Dorin Lixăndroiu
doaj  

Do Elections Slow Down Economic Globalization Process in India? It's Politics Stupid! [PDF]

, 2008
I investigate whether timing of the elections impact economic globalization process or not in India. In other words, do elections slowdown economic globalization process?
Vadlamannati, Krishna Chaitanya
core   +1 more source