Results 31 to 40 of about 67,077,240 (222)

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

E-government as a democratic catalyst: evidence from OECD countries (2006–2024)

Hitit Sosyal Bilimler Dergisi
This study investigates the causal relationship between e-government development and democracy across 38 OECD countries over the period 2006–2024. While the administrative benefits of e-government such as efficiency gains, cost reduction, and improved ...
Bora Kurtuluş, Helin Alagöz Gessler
doaj   +1 more source

Digital drivers of public management of countries’ economic development amid global changes [PDF]

Problems and Perspectives in Management
Type of the article: Research Article AbstractThis paper examines the digital drivers of public administration amid global transformations. Based on a comparative analysis of Denmark, Estonia, Singapore, South Korea, Poland, and Ukraine, five groups of ...
Olha Popelo, Olha Rudenko, Artur Zhavoronok, Nataliia Ivanova, Ihor Chobitok, Maryna Kanavets   +5 more
doaj   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Protocol for quantifying miRNA trafficking across the endosomal membrane

FEBS Open Bio, EarlyView.
An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh, Kamalika Mukherjee, Suvendra N. Bhattacharyya   +2 more
wiley   +1 more source

Assessing Digital Performance of Public Services in the EU: E-Governance and Technology Integration

Systems
This research aims to rank the regions of the European Union based on their digital performance in public services, offering a new perspective on the digitalization process and its effects on the European public system.
Oana Ramona Lobonț, Cristina Criste, Alexandra Ioana Vintilă, Andreea Florentina Crăciun, Nicoleta Claudia Moldovan   +4 more
doaj   +1 more source

E-Government Service for Driving Digital Creative Economy in Developing Region: Perspective of Technology Readiness Index and PLS-SEM

Applied Information System and Management (AISM)
E-government plays an important role in digital economic transformation by improving access to public services and driving economic growth. One implementation in West Papua Province is Rumahekraf, a digital marketing platform for creative economy players in the local region. However, the adoption of this platform is still low, and not many studies have
Nanes Fitri Rahmawati, Dedi I. Inan, Ratna Juita, Muhamad Indra   +3 more
openaire   +1 more source

Comparative assessment of crystallographic and cryo‐EM models in the Protein Data Bank

FEBS Open Bio, EarlyView.
Raw data obtained by X‐ray crystallography or cryo‐EM result in experimental maps, ultimately fitted by atomic models. Although the physical principles are different, the final results can be viewed, compared, and evaluated in the same way. With cryogenic electron microscopy (cryo‐EM) on track to surpass X‐ray crystallography as the preferred method ...
Alexander Wlodawer, Pawel Rubach, Zbigniew Dauter, Wojciech Dec, Dariusz Brzezinski, Marta Kulik, Wladek Minor, Mariusz Jaskolski   +7 more
wiley   +1 more source

DIGITAL COMPETITIVENESS INDICATORS AND THE E-GOVERNMENT PROCESS IN ROMANIA

Journal of Smart Economic Growth, 2018
The article showcases the results in Romania for the following indicators: Digital Economy and Society Index (EU28 DESI) defined for the countries in the European Union, International Digital Economy and Society Index (I-DESI), an extension of the UE28 ...
Dorin Lixăndroiu
doaj  

Is E-government an opportunity for all? Identifying barriers and enablers of E-government use among older adults in Europe

Social Sciences and Humanities Open
The European Union faces the dual challenges of an ageing population and the rapid digital transformation of public services through e-government.
Emanuela Sala, Ekaterina Kochergina
doaj   +1 more source