Results 31 to 40 of about 515,580 (260)

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

BER and outage probability of DPSK subcarrier intensity modulated free space optics in fully developed speckle. [PDF]

, 2009
In this paper a differential phase shift keying (DPSK) subcarrier intensity modulated (SIM) free space optical (FSO) link is considered in negative exponential atmospheric turbulence environment.
Ghassemlooy, Zabih, Leitgeb, Erich, Popoola, Wasiu Oyewole   +2 more
core   +2 more sources

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

E-government as a democratic catalyst: evidence from OECD countries (2006–2024)

Hitit Sosyal Bilimler Dergisi
This study investigates the causal relationship between e-government development and democracy across 38 OECD countries over the period 2006–2024. While the administrative benefits of e-government such as efficiency gains, cost reduction, and improved ...
Bora Kurtuluş, Helin Alagöz Gessler
doaj   +1 more source

The impact of socio-economic and political factors on the development of e-government in developed and developing countries [PDF]

Problems and Perspectives in Management
Type of the article: Research Article Abstract The current direction of state development is its focus on citizens (G2C). This transition is accompanied by digitalization, which enables the provision of services to citizens to reach a whole new level ...
Alibek Samarkhanov, Gulsara Junusbekova, Zhaxat Kenzhin, Daulet Yesmagambetov   +3 more
doaj   +1 more source

Enterprise Architecture: A Strategy to Achieve e-Government Dimension of Smart Village Using TOGAF ADM 9.2

JOIV: International Journal on Informatics Visualization, 2022
Transformation in village government with the enterprise architecture smart village design model is significant for developing digital technology in the village government environment to realize a government with aspects of integrity values that are in ...
Muhammad Ilham Alhari, Asti Amalia Nur Fajrillah   +1 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

E-Government Service for Driving Digital Creative Economy in Developing Region: Perspective of Technology Readiness Index and PLS-SEM

Applied Information System and Management (AISM)
E-government plays an important role in digital economic transformation by improving access to public services and driving economic growth. One implementation in West Papua Province is Rumahekraf, a digital marketing platform for creative economy players in the local region. However, the adoption of this platform is still low, and not many studies have
Nanes Fitri Rahmawati, Dedi I. Inan, Ratna Juita, Muhamad Indra   +3 more
openaire   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

DIGITAL COMPETITIVENESS INDICATORS AND THE E-GOVERNMENT PROCESS IN ROMANIA

Journal of Smart Economic Growth, 2018
The article showcases the results in Romania for the following indicators: Digital Economy and Society Index (EU28 DESI) defined for the countries in the European Union, International Digital Economy and Society Index (I-DESI), an extension of the UE28 ...
Dorin Lixăndroiu
doaj