Results 21 to 30 of about 58,719 (222)
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Molecular Oncology, EarlyView.LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David +12 more
wiley +1 more source
Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy
Molecular Oncology, EarlyView.LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir +9 more
wiley +1 more source
Al- Maǧallaẗ al-ʿarabiyyaẗ li-ʿilm al-tarǧumaẗThis research examines the correlation between e-government advancement and digital transaction expenses in Arab nations, highlighting the influence of cybersecurity maturity as a moderating factor.
Souhila Imansouren
doaj +1 more source
Molecular Oncology, EarlyView.This paper shows that size‐exclusion chromatography and sequential centrifugation applied to seminal plasma enrich for different populations of extracellular vesicles. This may significantly affect the detection and analysis of extracellular vesicle‐associated cancer biomarkers.
Elen Telumyan +8 more
wiley +1 more source
Molecular Oncology, EarlyView.Enterotoxigenic Bacteroides fragilis is a gut bacterium linked to bowel cancer. We propose that its toxin acts along two routes: at the cell surface, cutting the adhesion protein E‐cadherin and triggering inflammation; and inside the cell, delivered by bacterial vesicles, switching on NOD1 and cancer stem cell programs.
Kangchan Choi +2 more
wiley +1 more source
DIGITAL COMPETITIVENESS INDICATORS AND THE E-GOVERNMENT PROCESS IN ROMANIA
Journal of Smart Economic Growth, 2018 The article showcases the results in Romania for the following indicators: Digital Economy and Society Index (EU28 DESI) defined for the countries in the European Union, International Digital Economy and Society Index (I-DESI), an extension of the UE28 ...
Dorin Lixăndroiu
doaj
Protocol for quantifying miRNA trafficking across the endosomal membrane
FEBS Open Bio, EarlyView.An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh +2 more
wiley +1 more source
E-government as a democratic catalyst: evidence from OECD countries (2006–2024)
Hitit Sosyal Bilimler DergisiThis study investigates the causal relationship between e-government development and democracy across 38 OECD countries over the period 2006–2024. While the administrative benefits of e-government such as efficiency gains, cost reduction, and improved ...
Bora Kurtuluş, Helin Alagöz Gessler
doaj +1 more source
Institutional foundations of digital transformation of business in economic sectors
Вестник университета, 2023 The article examines the external prerequisites for the digital transformation of business in the Russian economy. The object of research is the institutional infrastructure of the digital economy. The subject of the study is the state digital ecosystem.
P. M. Gureev, I. S. Prokhorova
doaj +1 more source