Results 151 to 160 of about 428,333 (264)

Architecture and function of holocentric CENP-A-independent inner kinetochores. [PDF]

Sci Adv
Yu C, Sankaranarayanan SR, Cornilleau G, Howes AC, Azumaya CM, Day ES, Zilberleyb I, Brillantes B, Cheung TK, Dec L, Loew D, Tran P, Rose CM, Drinnenberg IA, Ciferri C, Yatskevich S.   +15 more
europepmc   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Ventricular assist device simulation to improve staff confidence and knowledge when caring for patients supported with the Berlin heart☆. [PDF]

J Extra Corpor Technol
Valido L, Duffy V, Rey E, Deitemyer M, Heard T, Pleiman J, Fernandez R.   +6 more
europepmc   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

An AI-Driven Multimodal Sensing Framework Integrating UAV Imagery and Environmental Sensors for Intelligent Farmland Monitoring. [PDF]

Sensors (Basel)
Li L, Song Y, Zhang Y, Guo P, Wang X, Ma Z, Yan S.   +6 more
europepmc   +1 more source

How phagocytic cells kill bacteria: Lessons from a professional killer

FEBS Open Bio, EarlyView.
How phagocytic cells ingest and kill bacteria has been studied for more than a century, but many questions remain unanswered. The study of the amoeba Dictyostelium discoideum brings new answers, and new questions. Professional phagocytic cells such as neutrophils and macrophages, as well as free‐living soil amoebae like Dictyostelium discoideum, employ
Otmane Lamrabet, Pierre Cosson
wiley   +1 more source

geneSCOPE: gene spatial co-occurrence of pairwise expression. [PDF]

Brief Bioinform
Zhang S, Saeki K, Haeno H.
europepmc   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

A thermodynamically consistent approach to modeling epithelial solute and water transport in the proximal convoluted tubule. [PDF]

J Biol Phys
Noroozbabaee L, Dowrick JM, Blanco PJ, Nickerson DP.   +3 more
europepmc   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source