Results 111 to 120 of about 21,181,337 (333)
Proxy of democracy? : metaphors of connection as arguments against representation [PDF]
, 2012 This paper aims to assess the arguments that claim representative democracy may be enhanced or replaced by an updated electronic version. Focusing on the dimension of elections and electioneering as the core mechanism of representative democracy I will ...
Cuono, Massimo
core
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Future generations computer systems, 2019 Online citizen public participation in consultation and decision-oriented processes supported by local governments is a key ingredient for successful digital democracy.
Mijail Naranjo-Zolotov +6 more
semanticscholar +1 more source
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
, 2011 We use a natural experiment to investigate the impact of participation constraints on individuals' decisions to invest in the stock market. Unexpected inheritance due to sudden deaths results in exogenous variation in financial wealth, and allows us to ...
Steffen Andersen, Kasper Meisner Nielsen
semanticscholar +1 more source
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
LandUrban streets, constituting the majority of public space, are often designed to prioritise vehicular movement over the pedestrian experience, leading to environments that can feel unsafe and unwelcoming.
Marcus White +5 more
doaj +1 more source
International Journal of Computing Sciences Research, 2017 Purpose – This paper seeks to answer the level and extent of involvement of the community in the government services to explore how information technologies may work to improve the services to the citizens as an input to e-governance initiative. Method
Francis F. Balahadia +5 more
doaj +1 more source
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
RUDN Journal of Political ScienceOptimizing government-citizen engagement amid Russia’s digital transformation requires a comprehensive approach that extends beyond technological solutions.
Svetlana S. Morozova
doaj +1 more source