Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
'Barriers' to participation in higher education? Depends who you ask and how
, 2008 In this article, we draw on evidence from a large-scale research project to explore the metaphorical concept of "barriers" to participation in higher education (HE) and to show how our data challenge the idea that non-participation by under-represented ...
Foskett, Ros +3 more
core
Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
FEBS Letters, EarlyView.In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source
Participation Outcomes In Rehabilitation For Individuals With Chronic Neurological Conditions
, 2018 The purpose of this research project was to identify personal and environmental factors that facilitate both ability to participate in life roles and satisfaction with that participation, for people living with chronic neurological conditions ...
Dobler, Sherry
core
Political cost, value balance, and the optimization of university public health emergency governance: an evolutionary game and small signal analysis. [PDF]
Front Public HealthWang R, Wu H, Liu Y, Li J, Li X, Li R.
europepmc +1 more source
Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source
From Technical Performance to Assistive Validity: A Critical Review of Evaluation Approaches for AI-Enabled Assistive Technology. [PDF]
Healthcare (Basel)Giraldo M, Sacchi F.
europepmc +1 more source
Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
Changes in vaping-related knowledge following the delivery of an educational intervention to university students in Mexico: a prospective follow-up study. [PDF]
BMJ OpenAcosta-Enriquez ME +4 more
europepmc +1 more source
FEBS Letters, EarlyView.Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source